Analysis of the relationship between the level of high-sensitive C-reactive protein and the risk factors of cardiovascular diseases in young and middle-aged persons
https://doi.org/10.33667/2078-5631-2021-23-58-65
Abstract
Objective. To evaluate the relationship between the level of high-sensitive C-reactive protein young and middle-aged people without history of cardiovascular complications.
Methods. Data from 427 patients aged 30-55 years old (median age -41 years old; men -83%), based on the center of diagnosis and rehabilitation of «Gazprom Transgaz Moscow» LLC from November 2018 to February 2020 were analyzed. All the participants conducted a comprehensive examination in accordance with the employee profession and order No. 302 of the Ministry of Health of the Russian Federation. Blood hs-CRP level was determined by an immunoturbodimetric method with latex amplification, with a lower detection limit of 0.1 mg/l.
Results. Hs-CRP in comparison with a normal body weight participants (0.52 [0.32;0.98] mg/l) was significantly higher in overweight persons (1.23 [0.68;2.11] mg/l) and in obese patients (1.84 [1.27;3.11] mg/l), as well as in patients with obesity in comparison with patients with overweight (p=0.0001 in all cases). The hs-CRP level in a group with systolic blood pressure (SBP) 120-129 mm Hg hs-CRP was 0.96 [0.50;1.96] mg/l, in the group with SBP 130-139 mm Hg - 1.52 [0.83;2.77] mg/l, in patients with SBP >140 mm Hg- 1.54 [1.03;2.19] mg/l (p = 0.0002). Similar significant (p=0.0002) relationships are revealed for office diastolic blood pressure (DBP). In patients with a total blood cholesterol >4.9 mmol/l (n=355), the average level of hs-CRP was 1.24 [0.60;2.19] mg/l, and in participant with normal total cholesterol (n=72) - 0.69 mg/l [0.37;1.80] (p = 0.002). Among all the analyzed persons, elevated levels of hs-CRP (> 2 mg/l) were associated with frequent flu (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.2-3.7; p=0.02) and an increase in the erythrocytes sedimentation rate (ESR) (OR 3.5, 95 % CI 1.5-8.03; p=0.004). After adjustment for sex, age and confounders hs-CRP >2 mg/l significantly associated with abdominal obesity (OR 2.2, 95 % CI 1.2-4.2; p=0.01) and hypertension (OR 1.9, 95 % CI 1.1-3.3; p=0.02).
Conclusion. In young and middle-aged persons passing PME, hs-CRP is a stable cardiovascular risk marker, associated with overweight, obesity, an increase in the total cholesterol level, office SBP and DBP, ESR, and with history of frequent flu.
About the Authors
O. A. Polyakova
Russian Medical Academy of Continuous Professional
Russian Federation
Russian Federation
Olga Aleksandrovna Polyakova, therapist, postgraduate at the department of therapy and polymorbid pathology
Moscow
A. A. Kirichenko
Russian Medical Academy of Continuous Professional
Russian Federation
Russian Federation
Andrey Apollonovich Kirichenko, doctor of medical sciences, full professor, professor at the department of therapy and polymorbid pathology
Moscow
A. I. Kochetkov
Russian Medical Academy of Continuous Professional
Russian Federation
Russian Federation
Aleksey Ivanovich Kochetkov, candidate of medical sciences, associate professor of the department of therapy and polymorbid pathology
Moscow
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Polyakova O.A., Kirichenko A.A., Kochetkov A.I. Analysis of the relationship between the level of high-sensitive C-reactive protein and the risk factors of cardiovascular diseases in young and middle-aged persons. Medical alphabet. 2021;(23):58-65. (In Russ.) https://doi.org/10.33667/2078-5631-2021-23-58-65
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