Genetic predisposition and resistance to certain infectious diseases. III. COVID 19
https://doi.org/10.33667/2078-5631-2021-13-7-12
Abstract
The review discusses issues related to genetic predisposition and resistance to the new coronavirus infection including various factors: epidemiological, gender, ethnic and microbiome. The role of molecular genetic methods in the diagnosis of coronavirus infection is emphasized. The genetic factors largely determine the body’s susceptibility to various diseases, including infectious ones. The focus is on the genes associated with the production of interferons and enzymes that are responsible for anti-viral responses, as well as inflammatory reactions in the lungs. The first group includes genes IFNAR2 and OAS1, which control the production of antiviral proteins, while the second includes DPP9, TYK2 and CCR2, that control the behavior of monocytes. A number of other genetic polymorphisms responsible for resistance and susceptibility to infections and associated clinical consequences are discussed. The knowledge of molecular genetic biomarkers is necessary to identify risk groups, conduct predictive measures, including vaccination against COVID-19.
About the Authors
S. N. Scherbo
Russian National Research Medical University n.a. N.I. Pirogov
Russian Federation
Russian Federation
Shcherbo Sergey N., Dr Bio Sci, prof., head of Dept of Clinical Laboratory Diagnostics.
Moscow
D. S. Shcherbo
Russian National Research Medical University n.a. N.I. Pirogov
Russian Federation
Russian Federation
Scherbo Dmitry S., PhD Bio Sci, associate prof. at Dept of Clinical Laboratory Diagnostics.
Moscow
A. L. Tishchenko
People’s Friendship University of Russia
Russian Federation
Russian Federation
Tishchenko Andrey L., MD, DSc, prof., head of Dept of Skin and Venereal Diseases with course of cosmetology at Medical Institute.
Moscow
M. I. Savina
Russian National Research Medical University n.a. N.I. Pirogov
Russian Federation
Russian Federation
Savina Marina I., Dr Bio Sci, prof., prof. at Dept of Clinical Laboratory Diagnostics.
Moscow
T. I. Turkina
Russian National Research Medical University n.a. N.I. Pirogov
Russian Federation
Russian Federation
Turkina Tatiana I., Dr Bio Sci, prof., prof. at Dept of Clinical Laboratory Diagnostics.
Moscow
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Review
For citations:
Scherbo S.N., Shcherbo D.S., Tishchenko A.L., Savina M.I., Turkina T.I. Genetic predisposition and resistance to certain infectious diseases. III. COVID 19. Medical alphabet. 2021;(13):7-12. (In Russ.) https://doi.org/10.33667/2078-5631-2021-13-7-12
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