Targeted therapy for advanced non-small cell lung cancer with ALK translocation: brigatinib expands our capabilities and ensures success in fight against disease progression
https://doi.org/10.33667/2078-5631-2021-10-53-60
Abstract
The article explores a role of brigatinib in a basic strategy of treatment of ALK-positive non-small-cell lung cancer (NSCLC) patients with progressive disease on or with intolerance to crizotinib. Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, at an approved dose of 180 mg once daily (with 7-day lead-in at 90 mg) is associated with extremely high activity against a wide range of ALK mutations. Brigatinib demonstrate improvement in both, long-term efficacy (the median progression-free survival is 16.7 months, the median overall Survival is 34.1 months) and short-term response to treatment. Thus, in ALTA trial Brigatinib at a dose of 180 mg per day (with lead-in) in the 2nd line of targeted therapy, was associated with IRC (independent review committee)-assessed overall objective response rate of 56 % and the median duration of response of 15.7 months. Brigatinib demonstrated a high efficacy against intracranial disease: the rate of objective response in measurable brain metastases was 67 %, the median duration of response was 16.6 months, and the median progression-free survival in the central nervous system was 18.4 months. The safety profiles of brigatinib characterized by predictable and manageable toxicity. Brigatinib demonstrate the same high efficacy and good tolerability in Russian ALK+ NSCLC patients within early access programme. The expected approval of brigatinib for ALK+ NSCLC patients in the Russian Federation in the 2nd line of treatment can significantly expand our capabilities in the fight against this formidable disease.
About the Author
E. V. Artamonova
National Medical Research Centre of Oncology n.a. N. N. Blokhin; Russian National Research Medical University n.a. N. I. Pirogov
Russian Federation
Russian Federation
Artamonova Elena V., DM Sci, head of Chemotherapy Dept No. 1; prof. at Oncology and Radiotherapy Dept
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Review
For citations:
Artamonova E.V. Targeted therapy for advanced non-small cell lung cancer with ALK translocation: brigatinib expands our capabilities and ensures success in fight against disease progression. Medical alphabet. 2021;(10):53-60. (In Russ.) https://doi.org/10.33667/2078-5631-2021-10-53-60
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