Combined immunotherapy of colorectal cancer in young patient with microsatellite instability (clinical case)
https://doi.org/10.33667/2078-5631-2021-10-16-21
Abstract
At present administration of a combination of several immune checkpoint inhibitors (ICT) for the treatment of colorectal cancer (CRC) demonstrates promising results, but clinical trials of that approach are lacking, especially in patients with high microsatellite instability (MSI-H).
Aim. To describe the efficacy of combination of ICT therapy in a female patient with CRC and MSI-H.
Results. A clinical case of a young female patient with transverse colon cancer with T4N 2M1 IV stage is presented. Patient underwent a course of chemotherapy. After disease progression a course of ICT therapy with nivolumab and ipilimumab (four courses) with subsequent 21 course of nivolumab were performed, with positive clinical dynamics. Immune-mediated adverse events included peripheral polyneuropathy (2nd grade), immune-mediated hypothyreosis and immune-mediated arthritis.
Conclusions. Further studies are needed in a subgroup of patients with metastatic CRC with MSI-H to develop treatment approaches utilizing ICT and additional treatment modalities with maximal efficacy.
About the Authors
M. A. Lyadova
City Clinical Oncology Hospital No. 1
Russian Federation
Russian Federation
Lyadova Marina A., PhD Med, head of Chemotherapy Dept.
Moscow
T. A. Nersesova
City Clinical Oncology Hospital No. 1
Russian Federation
Russian Federation
Nersesova Tatiana A., oncologist
Moscow
M. Yu. Fedyanin
National Medical Research Centre of Oncology n.a. N. N. Blokhin; Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Fedyanin Mikhail Yu., DM Sci, chief researcher; associate prof. at Oncology and Hematology Dept.
Moscow
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Review
For citations:
Lyadova M.A., Nersesova T.A., Fedyanin M.Yu. Combined immunotherapy of colorectal cancer in young patient with microsatellite instability (clinical case). Medical alphabet. 2021;(10):16-21. (In Russ.) https://doi.org/10.33667/2078-5631-2021-10-16-21
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