Influence of interference of light and laser technologies on microcirculation in involutive changes of skin

In a study of 115 patients, the effect of the interference of IPL exposure using filters of 640 nm and 560 nm and the use of an erbium fractional laser with a wavelength of 1565 nm on microcirculation in patients with involutive skin changes was studied. The basis of all reparative processes is the microcirculatory link, as a unit of the trophic system of the skin. Studying the effect of phototechnologies and laser fractional exposure on microcirculation, based on the results of these studies, it is possible to develop algorithms for patient management, including additional treatment methods, as well as an algorithm for standardizing procedures, including the multiplicity and number of procedures. These studies can be the starting point for the introduction of standards that will reduce the number of complications, as well as increase the clinical effectiveness of the treatment, which will make the method more widely available. The assessment of the state of microcirculation was carried out using the method of laser Doppler flowmetry (LDF), using the mathematical analysis of the wavelet transform. Under the influence of the interference of IPL exposure using filters of 640 nm and 560 nm and the use of an erbium fractional laser with a wavelength of 1565 nm, a positive dynamics of the parameters of all parts of the microcirculation was revealed according to the LDF data. In women with spastic type of MC, the initially increased neurogenic and myogenic tone of the arterioles decreased, and endothelial function improved. In women with hyperemic type of MC, there was an improvement in neurogenic tone, correction of endothelial dysfunction, and elimination of congestion in the venular link of MC. However, the above changes were more noticeable in patients with hyperemic type of MC.

1. Yusova Zh. Yu. Involutional skin changes by morphological type. Kuznetsova A. O., Sokolova-Merkurieva A.V., Klivitskaya N. A. Bulletin of Postgraduate Medical Education. 2013. No. 4. С. 31–34.

2. Physiotherapy in Dermatology. Kruglova L. S., Kotenko K. V., Korchazhkina N. B., Turbovskaya S. N. Moscow, 2016.

3. Potekaev N. N., Kruglova L. S. Laser in dermatology and cosmetology. 2nd edition, revised and enlarged. Moscow, 2015.

4. Servuli E. Hardware cosmetology for home becomes a reality. Hardware cosmetology and physiotherapy 2012; 1: 26–33.

5. Kruglova LS, Tarasova OV, Rzhevskaya LV Application of laser therapy in patients with involutive skin changes on the background of type 2 diabetes mellitus. Physiotherapist. 2019. No. 4. S. 30–37.

6. Asayama-Kosaka S., Akilov O. E., Kawana S. Photodynamic Therapy with 5 % δ-Aminolevulinic Acid is Safe and Effective Treatment of Acne Vulgaris in Japanese Patients. Laser Ther 2014; 23 (2): 115–20.

7. Bitter P. Jr., Pozner J. Retrospective Evaluation of the Long-term Antiaging Effects of Broad Band Light Therapy. Cosmet Dermatol 2013: 34–40.

8. Goldberg D. J. Current Trends in Intense Pulsed Light. J Clin Aesthet Dermatol 2012; 5 (6): 45–53.

9. Novikov K. A., Tamrazova O. B., Kruglova L. S., Khussainova A. T. Treatment of papulopustular rosacea with a submillisecond neodymium 1064-nm laser Journal of Advanced Research in Dynamical and Control Systems. 2019. Т. 11. No. 1 Special Issue. С. 519–528.

10. Yusova Zh. Yu., Kruglova L. S. Combined use of laser and cellular technologies in the correction of age-related skin changes. Physiotherapist. 2017. No. 5. P. 18–22.

11. Yusova Zh. Yu., Baranova EL, Kruglova L. S. Clinical effectiveness of selective ablative laser methods in the correction of aesthetic skin imperfections. Physiotherapist. 2019. No. 5. P. 10–14.

12. Serebryakov V. A. Basic lecture notes for the course «Laser technologies in medicine». SPb: SPbGU ITMO, 2009.

13. Shirakawa M., Ozawa T., Tateishi C., Fujii N., Sakahara D., Ishii M. Intense pulsed light therapy for aberrant Mongolian spots. Osaka City Med J 2012; 58 (2): 59–65.

14. Goldman M. P., Weiss R. A., Weiss M. A. Intense pulsed light as a nonablative approach to photoaging. Dermatol Surg 2005; 31 (9 Pt 2): 1179–1187.

15. Raulin C., Hellwig S., Schönermark M. P. Treatment of a nonresponding port-wine stain with a new pulsed light source (Photo Derm VL). Lasers Surg Med1997; 21 (2): 203–8.

16. Harris K., Ferguson J., Hills S. A comparative study of hair removal at an NHS hospital: Luminette intense pulsed light versus electrolysis. J Dermatolog Treat 2014; 25 (2): 169–73.

17. Hession M. T., Markova A., Graber, E.M. A Review of Hand-Held, Home-Use Cosmetic Laser and Light Devices. Dermatologic Surgery 2015; 41 (3): 307–320.

18. Kassir R., Kolluru A., Kassir M. Intense pulsed light for the treatment of rosacea and telangiectasias. J Cosmet Laser Ther 2011; 13 (5): 216–22.

19. Metelitsa A. I., Green J. B. Home-use laser and light devices for the skin: an update. Semin Cutan Med Surg 2011; 30 (3): 144–7.

20. Moreno Arias G. A., Ferrando J. Intense pulsed light for melanocytic lesions. J Dermatol Surg 2001; 27 (4): 397–400.

21. Omi T. Photopneumatic technology in acne treatment and skin rejuvenation: histological assessment. Laser Ther 2012; 21 (2): 113–23.

22. Anderson R. R., Parrish J. A. Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science. 1983; 220 (4596): 524–7.

23. Radmanesh M., Azar-Beig M., et al. Burning, paradoxical hypertrichosis, leukotrichia and folliculitis are four major complications of intense pulsed light hair removal therapy. J Dermatolog Treat 2008; 19 (6): 360–363.

24. Wong W. R., Shyu W. L., Tsai J. W., Hsu K. H., Pang J. H. Intense pulsed light effects on the expression of extracellular matrix proteins and transforming growth factor beta-1 in skin dermal fibroblasts cultured within contracted collagen lattices. Dermatol Surg 2009; 35 (5): 816–25.

25. Deev A. I., Sharova A. A., Bragina I. Yu. New cosmetology. Hardware cosmetology and physiotherapy. Moscow: LLC Publishing House «Cosmetics and Medicine», 2014.

26. Klyuchareva S. V., Ponomarev I. V. Treatment of vascular skin neoplasms using lasers. Attending physician 2006; 3: 62–65.)

27. Agafonova EV, Kruglova LS, Rosacea: topical issues of therapy using physical factors. Physiotherapist No. 5. 2017. 2017; 5.

28. Yusova Zh. Yu., Kruglova L. S. Influence of the combined use of laser therapy and autologous blood plasma with cells on the processes of microcirculation in involutive skin changes. Physiotherapist. 2017. No. 6. P. 58–64.

29. Gunin A. G., Golubtsova N. N. Transforming growth factor-β (TGF-β) in human skin during aging. Advances in Gerontology. 2019. No. 1–2. Т. 32. P. 12–19