Role of matrix metalloproteinases in acne inflammation: pathogenesis, diagnosis, treatment, prognosis
https://doi.org/10.33667/2078-5631-2021-9-24-28
Abstract
Modern therapeutic views on the pathogenesis of acne indicate the role of permanent inflammation and expand the arsenal of medicines and combined techniques necessary for the successful treatment of this chronic skin disease. The complex process of immune inflammation in acne with the participation of pro-inflammatory cytokines is due to the interaction of trigger factors and factors of innate immunity. It was found that C. acne is able to interact with markers of increased immunity, such as Toll-like and protease-activated receptors. Based on a detailed analysis of the literature in search systems like PubMed, eLibrary.ru, CyberLeninka, it was found that one of the key roles in inflammation in acne belongs to matrix metalloproteinases. Thus, C. acnes are involved in many processes in the pathogenesis of acne, including inflammation, hyperkeratosis and hyperproduction of sebum, which necessitates its eradication and is an important component of complex therapy. Minocycline (Minolexin) is a highly effective drug for the treatment of moderate to severe forms of acne, including a low-dose regimen, and is included in the European Treatment Guidelines. Minocycline is considered the most powerful inhibitor of MMP, has a pronounced anti-inflammatory effect and a high level of lipophilicity, quickly penetrates the lipid layer of the bacterium and intensively accumulates in the sebaceous glands.
About the Authors
A. R. Nazarenko
Moscow Scientific and Practical Centre for Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Nazarenko Alina R., 3rd year postgraduate student of Clinical Dermatovenerology and Cosmetology Dept
N. N. Potekaev
Moscow Scientific and Practical Centre for Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Potekaev Nikolay N.,DM Sci, prof., director
A. N. Lvov
Moscow Scientific and Practical Centre for Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Lvov Andrey N.,head of Clinical Dermatovenerology and Cosmetology Dept
N. L. Klyachko
Moscow State University n. a. M. V. Lomonosov
Russian Federation
Russian Federation
Klyachko Natalia L,Dr Chem Sci, prof. at Faculty of Chemistry, Lomonosov Moscow State University, deputy director of REC for Nanotechnology
A. G. Majouga
Moscow State University n. a. M. V. Lomonosov; Russian University of Chemical Technology n. a. D. I. Mendeleev
Russian Federation
Russian Federation
Mazhuga Alexander G, Dr Chem Sci, prof. of Russian Academy of Sciences, head of Laboratory of Tissue-Specific Ligands at Faculty of Chemistry, rector
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Review
For citations:
Nazarenko A.R., Potekaev N.N., Lvov A.N., Klyachko N.L., Majouga A.G. Role of matrix metalloproteinases in acne inflammation: pathogenesis, diagnosis, treatment, prognosis. Medical alphabet. 2021;(9):24-28. (In Russ.) https://doi.org/10.33667/2078-5631-2021-9-24-28
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