Electroencephalography and somatosensory evoked potentials in Covid-19 patients. Experience in recording and using telemedicine technologies to analyze results
https://doi.org/10.33667/2078-5631-2021-5-7-12
Abstract
A new coronavirus COVID-19 has led to the development of a global pandemic. It is characterized by a high risk of developing pneumonia and multiple organ failure along with its capability to influence the central nervous system. The main methods of instrumental assessment of the functional state of the brain are electroencephalography (EEG) and somatosensory evoked potentials (SEPs), which have been routinely used with patients in critical care units.
We recorded the EEGs and short-latency SEPs of 31 COVID-19 patients, all were treated at the N. V. Sklifosovsky Research Institute of Emergency Care in 2020. The combined data was used to analyse the following outcome.
We detected abnormal EEGs in 23 COVID-19 patients (74 %). Seven (30.4 %) patients showed EEGs consisting of diffuse non-specific slowing, 4 patients had lateralized hemispheric slowing (17.4 %) and one patient (4,3 %) had frontal intermittent delta activity (FIRDA). Three (13 %) patients in comas had “burst-suppression» pattern, three (13 %) had isoelectric EEGs and two (8,7 %) had areactive alpha rhythm, regarded as an electrographic manifestation of alpha coma. Two patients had evidence of epileptiform discharges (9 %), triphasic waves were presented in one patient (4.3 %).
EEG and SEPs with the median nerve stimulation in COVID-19 patients do not reveal specific changes, nevertheless they are informative instrumental methods for assessing the functional state of the brain to identify biomarkers of epileptic seizures and to prognosticate survival and recovery in comatose patients.
About the Authors
M. V. Sinkin
N. V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
E. G. Seliverstova
N. V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
L. T. Khamidova
N. V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
K. A. Popugaev
N. V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
A. A. Grin
N. V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
S. S. Petrikov
N. V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
References
1. Beresten’ N. F., Sandrikov V. A., Fedorova S. I. Funktsional’naya diagnostika: natsional’noe rukovodstvo [Functional Diagnostics: National Guedelines]. Moscow: GEOTAR-Media, 2019.
2. Voitenkov V. B., Sinkin M. V., Aleksandrov M. V., Ekusheva E. V., Klimkin A. V., Bedova M. A., Seliverstova E. G. The features of clinical neurophysiology examination throughout the COVID-19 pandemic. Medical alphabet. 2020;(25):26–29. (In Russ.) https://doi.org/10.33667/2078-5631-2020-25-26-29
3. Petrikov S. S., Роpugaev K. A., Khamidova L. T., Rybalko N. V., Abuchina V. M., Alekseechkina O. A. First experience of lung ultrasound application in patients with acute viral infection caused by SARS-CoV-2. Medical Visualization. 2020;24(2):50–62. (In Russ.) https://doi.org/10.24835/1607-0763-2020-2-50-62
4. Guidelines for carring out of routine EEG of neurophysiology expert board of Russian league against epilepsy. Epilepsy and paroxysmal conditions. 2016;8(4):99–108. (In Russ.)
5. Canham L. J.W., Staniaszek L. E., Mortimer A. M., Nouri L. F., Kane N. M., Electroencephalographic (EEG) features of encephalopathy in the setting of COVID-19: A Case Series, Clinical Neurophysiology Practice (2020), doi: https://doi.org/10.1016/j.cnp.2020.06.001
6. Dericioglu N., Khasiyev F., Arsava E. M., Topcuoglu M. A. Frontal Intermittent Rhythmic Delta Activity (FIRDA) in the Neurological Intensive Care: Prevalence, Determinants, and Clinical Significance. Clin EEG Neurosci. 2018;49(4):272–277. doi:10.1177/155005941668810
7. Gélisse P., Rossetti A. O., Genton P., Crespel A., Kaplan P. W. How to carry out and interpret EEG recordings in COVID-19 patients in ICU? [published online ahead of print, 2020 May 13]. Clin Neurophysiol. 2020; S1388–2457 (20) 30176-0. doi:10.1016/j.clinph.2020.05.006
8. Houlden D. A., Li C., Schwartz M. L., Katic M. Median nerve somatosensory evoked potentials and the Glasgow Coma Scale as predictors of outcome in comatose patients with head injuries. Neurosurgery. 1990;27(5):701–708. doi:10.1097/00006123-199011000-00006
9. Pastor J.; Vega- Zelaya L.; Martín Abad E. Specific EEG Encephalopathy Pattern in SARS-CoV-2 patients. J. Clin. Med.2020, 9(5), 1545; https://doi.org/10.3390/jcm9051545
10. Pati S., Toth E., Chaitanya G., Quantitative EEG markers to Prognosticate Critically ill Patients with COVID-19: A Retrospective Cohort Study, Clinical Neurophysiology (2020), doi: 10.1016/j.clinph.2020.06.001
11. Pleasure S. J., Green A. J., Josephson S. A. The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection. JAMA Neurol. 2020;77(6):679. doi:10.1001/jamaneurol.2020.1065
12. San- Juan D., Jiménez C. R., Camilli C. X. et al. Guidance for clinical neurophysiology examination throughout the COVID-19 pandemic. Latin American chapter of the IFCN task force — COVID-19. Clin Neurophysiol. 2020;131(7):1589–1598. doi:10.1016/j.clinph.2020.04.011
13. Vespignani H., Colas D., Lavin B. S. et al. Report of EEG Finding on Critically Ill Patients with COVID-19 [published online ahead of print, 2020 Jun 13]. Ann Neurol. 2020;10.1002/ana.25814. doi:10.1002/ana.25814
Review
For citations:
Sinkin M.V., Seliverstova E.G., Khamidova L.T., Popugaev K.A., Grin A.A., Petrikov S.S. Electroencephalography and somatosensory evoked potentials in Covid-19 patients. Experience in recording and using telemedicine technologies to analyze results. Medical alphabet. 2021;(5):7-12. (In Russ.) https://doi.org/10.33667/2078-5631-2021-5-7-12
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