Risks of legionella pneumonia in patients receiving immunosuppressive therapy
https://doi.org/10.33667/2078-5631-2020-34-22-27
Abstract
The legionellosis infection associated with medical care is usually registered for patients with reduced immunity, including those receiving immunosuppressive therapy. Prevention of nosocomial legionellosis in patients is essential due to high mortality. The aim. Analyze of the potential risks of legionellosis infection in patients of surgical departments. Materials and methods. Isolation of Legionella pneumophila from water supply systems in Moscow hospitals and serotyping of the isolated microorganism was performed using bacteriological, molecular genetic and enzyme immunoassay methods. Results and discussion. The study showed that there are potential risks of disease in surgical departments of hospitals that provide medical care, including immunocompromised patients. The content of Legionella pneumophila in water reached 10 5 CFU/l. The share of Legionella pneumophila SG 1, which causes up to 80 % of cases of legionellosis in the world, is 13 % in the water of the surveyed hospitals. The only action prevention of legionellosis is the biological safety of water. Conclusion. Due to the presence of potential risks, prevention of legionellosis is a necessary component of ensuring the safety of the treatment process for patients with immunosuppression.
About the Authors
O. A. Gruzdeva
First Moscow State Medical University n. a. I. M. Sechenov; Centre for Hygiene and Epidemiology in Moscow
Russian Federation
Moscow
Russian Federation
Moscow
I. S. Tartakovsky
National Research Centre for Epidemiology and Microbiology n. a. Honorary Academician N. F. Gamaleya
Russian Federation
Moscow
Russian Federation
Moscow
S. O. Sharapchenkо
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
N. I. Gabrielyan
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
References
1. A. Torres, F. Blasi, W. E. Peetermans, G. Viegi. The aetiology and antibiotic management of community-acquired pneumonia in adults in Europe: a literature review. Eur. J. Clin. Microbiol. Infect. Disр. 2014. No.33. P. 1065–1079.
2. Legionellosis-USA (New Jersey) Nosocomial, fatal. ProMED-mail, Newsday. 2008, Oct. 3
3. M. Ricci, S. Fontana, S. Achene et. al. In vitro study of H 2 O 2 -Ag + activity against Legionella and evaluation of its efficacy in hospital waterborne infection control. ‘Legionella 2009’ abstract book. Institut. Pasteur, France. 2009. P. 187–188.
4. Den Boern W. Jeroen, M. E. Sjoerd, P. Brandsema et. al. Results from the National Legionella Outbreak Detection Program, the Netherlands, 2002–2012. Emerging Infectious Diseases. 2015. No. 7. P. 1167–1173.
5. C. Сampese, B. Decludt. Notified cases of Legionnaires disease in France. Eurosurveillance. 2004. No.7. P. 121–128.
6. J. E. Stout, V. L. Yu. Hospital-acquired Legionnaires Disease: new developments. Curr. Opin. Infect. Dis. 2003. No.16 (4). P. 337–338.
7. Legionella and prevention of Legionellosis. Ed. by J. Bartram. WHO. 2007.
8. A.G. CHuchalin, A. I. Sinopal’nikov, I. S. Tartakovskij i dr. Prakticheskie rekomendacii po diagnostike i lecheniyu legionelleznoj infekcii, vyzyvaemoj Legionella pneumophila serogruppy 1. Posobie dlya vrachej. Rossijskoe Respiratornoe obshchestvo, M.: MAKMAH. 2009.
9. A. Cooper, H. R. Barnes, E. R. Myers Assessing risk of Legionella. ASHRAE Journal. 2004. No. 46 (4). P. 22–26.
10. YU.E. Dronina, I. S. Tartakovskij, K. Lyuk, YU. Hel’big, O. V. Sadretdinova, T. I. Karpova. Monoklonal’nye antitela k liposaharidu legionell i ih znachenie dlya tipirovaniya vozbuditelya. ZHizn’ bez opasnostej. Zdorov’e. Profilaktika. Dolgoletie. 2010. No. 4. P. 122–125.
11. McCormick, S. Thorn, D. Milne et. al. Public Health response to an outbreak of Legionnaires Disease in Edinburgh. United Kingdom. Eurosurveillance. 2012. No. 17 (28). P. 200–216.
12. Luderowski E, Harris CM, Khaliq W, Kotwal S. Severe Atypical Pneumonia Causing Acute Respiratory Failure. Am J Med.– 2020.– № 133(6): e230-e232. doi: 10.1016/j.amjmed.2019.10.034.
13. G. M. Galstyan, I. E. Kostina, S. A. Katrysh i dr. Klinicheskie proyavleniya legionelleznoj pnevmonii u gematologicheskih bol’nyh. Terapevticheskij arhiv. 2014. Vol. 86. No. 3. P. 45–52.
14. I. S. Tartakovskij, O. A. Gruzdeva, G. M. Galstyan, T. I. Karpova Profilaktika, diagnostika i lechenie legionelleza. Moskva: Studiya MDV, 2013. P. 344.
15. L.K.L. Jacobson, M. H. Miceli, J. J. Tarrand, D. P. Kontoyiannis. Legionella pneumonia in cancer patients. Medicine (Baltimore). 2008. No. 87 (3). P. 152–159.
16. I. S. Tartakovskij, A. L. Gincburg, G. F. Lazikova i dr. Standarty laboratornoj diagnostiki legionelleza i ih primenenie vo vremya epidemicheskoj vspyshki pnevmonij v g. Verhnyaya Pyshma. ZHurnal mikrobiologii, epidemiologii i immunobiologii. 2008. No. 2. P. 16–20.
17. L. V. Sokolova, O. S. Litvinova, V. A. Kadyshev, V. S. Kozlova Sluchaj legionellyoza iz praktiki. Tezisy dokladov IH nauchno-prakticheskoj konferencii ‘Infekcionnye bolezni i antimikrobnye sredstva’ (Moskva, oktyabr’ 2011 g.). P. 79–80.
18. European guidelines for control and prevention of Travel associated legionellosis. 2002.
19. CDC. Surveillance for waterborne disease outbreaks associated with drinking water – United States, 2009–201. MMWR Surveill. Samm. 2013. V. 63. P. 714–720.
20. P. Borellia, M. Montagna, V. Romano-Spica et. al. Legionella infection risk from domestic hot water. Emerg. Infect. Dis. 2004. No. 10. P. 457–464.
21. R. Donlan, J. W. Costerton Biofilms: survival mechanisms of clinically relevant. Mendeley, Biological Sciences. 2002. No. 15 (2). P. 167–193.
22. M. Olson, H. Ceri, D. W. Morck et. al. Biofilm bacteria: Formation and Comparative Susceptibility to antibiotics. Can. J. Vet. Res. 2002. No. 66. P. 86–92.
23. J. S. Colbourne, J. Ashworth Rubbers, waters and Legionella. Lancet. 1986. No. 2 (8506). P. 583.
24. M. A. Ryder. Catheter-related infections: it’s all about biofilms. Topics in advanced practice nursingе Journal. 2005. No. 5 (3). P. 1–6.
25. C. Jemberg, C. Schonning, M. Lofdahl et. al. Establishment of a link between a patient with Legionellosis and a dental unit. 2 ESGLI congress ESCMID Study Group for Legionella Infections (Barcelona, Spain, 17–19 September, 2014). P. 12.
26. T. J. Marrie et. al. Nosocomial legionnaires disease: lessons from a four-year prospective study. American Journal of Infections Control.1991. No. 19. P. 79–85.
27. R. A. Venezia, M. D. Agresta, E. M. Hanley et. al. Nosocomial legionellosis associated with aspiration of nasogastric feedings diluted in tap water. Infect. Control Hosp. Epidemiol. 1994. No. 15. P. 529–533.
28. V. Thomas, Bouchez T., Nicolas V. et al. Amoebae in domestic water systems: resistance to disinfection treatments and implication in Legionella persistence. J. Appl. Microbiol. 2004. Vol. 97, No. 5. P. 950–963.
29. Guidelines for preventing health-care associated pneumonia 2003: recommendation of CDC and the Health care Infection Control Practices Advisory Committee. MMWR Recomm. Rep. 2004. No. 26, 53 (RR-3). P. 1–36.
Review
For citations:
Gruzdeva O.A., Tartakovsky I.S., Sharapchenkо S.O., Gabrielyan N.I. Risks of legionella pneumonia in patients receiving immunosuppressive therapy. Medical alphabet. 2020;(34):22-27. (In Russ.) https://doi.org/10.33667/2078-5631-2020-34-22-27
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