Simultaneous colonization by gram-negative hospital pathogens
https://doi.org/10.33667/2078-5631-2020-34-13-16
Abstract
Objectives. Assessment of the probability of simultaneous infection with two or more pathogens of clinical substrates of transplant patients. Materials and methods. The retrospective analysis of bacteriological studies of clinical isolates among transplant patients operated from January to July 2020 is performed. This study included 93 patients. Results and discussion. Тhe risk of bacterial complications in the postoperative period is associated with representatives of the gram-negative pathogens Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. All the studied strains were resistant to antibiotics. A significant number of coinfections with two or three pathogens cases were recorded in the current period – 20.4 %. For the two and more pathogens’ colonization the highest mortality rate is shown, 42.1 %. Conclusions. Modern epidemiological feature is the Acinetobacter baumannii predominance among the microflora of transplant patients. It has been shown that the incidence of co-colonization by ≥ 2 different gram-negative pathogens is significant and increases the mortality rate.
About the Authors
N. I. Gabrielyan
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
V. G. Kormilitsina
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
M. Kh. Kurbanova
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
N. M. Esenova
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
S. O. Sharapchenko
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
R. Sh. Saitgareev
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
V. M. Zakharevich
National Medical Research Centre for Transplantology and Artificial Organs n. a. academician V. I. Shumakov
Russian Federation
Moscow
Russian Federation
Moscow
O. V. Kisil
Scientific Research Institute for the Research of New Antibiotics n. a. G. F. Gauze
Russian Federation
Moscow
Russian Federation
Moscow
V. V. Maleev
Central Research Institute of Epidemiology
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Zemko V. Ju., Okulich V. K., Dzjadz’ko A. M. Monitoring antibiotikorezistentnosti mikroorganizmov v otdelenii reanimacii i intensivnoj terapii mnogoprofil’nogo stacionara. Transplantologija. 2018; 10 (4): 284–297. (In Russ.). DOI: 10.23873/2074–0506–2018–10–4284–297.
2. Zeana C, Larson E, Sahni J, et al. The epidemiology of multidrug-resistant Acinetobacter baumannii: does the community represent a reservoir? Infect Control Hosp Epidemiol. 2003; 24: 275–279. DOI: 10.1086/502209.
3. Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs: no ESKAPE! An update from the infectious diseases’ society of America. Clin. Infect. Dis. 2009; 48 (1): 1–12. DOI: 10.1086/595011.
4. Tacconelli E, Carrara E, Savoldi A, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect. 2018; 18 (3): 318–327. DOI: 10.1016/S1473–3099(17)30753–3.
5. Gabrielyan N. I., Aref’eva L.I., Stolyarova L. G. Organizaciya i provedenie epidemiologicheskogo i mikrobiologicheskogo monitoringa v kardiohirurgicheskoj klinike. M.: Rossijskaya medicinskaya akademiya poslediplomnogo obrazovaniya (In Russ.).
6. Gabrielyan N. I., Sharapchenko S. O., Drabkina I. V., et al. Gramotritsatel’nye gospital’nye patogeny v riske razvitiya tyazhelykh bakterial’nykh infektsii. Meditsinskii alfavit. 2019; 1 (15): 31–35. (In Russ.). DOI: 10.33667/2078–5631–2019–1–15(390)-31–35.
7. Gabrielyan N. I., Sharapchenko S. O., Kisil’ O.V., i dr. Problema global’nogo razvitiya antibiotikoustojchivosti vozbuditelej nozokomial’nyh infekcij. Terrapevticheskij arhiv. 2020;192 (11): 110–116. (In Russ.). DOI:10.26442/00403660.2020.11.000783
8. Beloborodov B. V., Gusarov V. G., Dehnich A. V., et al. Medodicheskie rekomendacii ‘Diagnostika i antimikrobnaja terapija infekcij, vyzvannyh polirezistentnymi mikroorganizmami’. Vestnik anesteziologii i reanimatologii. 2020; 16 (1): 52–83. (In Russ.). DOI: 10.21292/2078–5658–2020–16–1–52–83.
9. Romanova N. I., Gorskaya E. M., Esenova N. M., et al. Mikroflora vneshnej sredy kak ugroza razvitiya infekcionnoj patologii u pacientov posle ortotopicheskoj transplantacii serdca. Medicinskij alfavit. 2016; 1 (15): 47–53.
10. Mammina C, Bonura C, Vivoli AR, et al Co-colonization with carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii in intensive care unit patients. Scandinavian journal of infectious diseases. 2013; 45 (8): 629–634. DOI: 10.3109/00365548.2013.782614.
11. Snyder GM, O’Fallon E, D’Agata EM. Co-colonization with multiple different species of multidrug-resistant gram-negative bacteria. Am J Infect Control. 2011; 39 (6): 506–510. DOI: 10.1016/j.ajic.2010.09.012.
12. Lee CR, Lee JH, Park M, et al. Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options. Front Cell Infect Microbiol. 2017; 7: 55. DOI: 10.3389/fcimb.2017.00055.
13. Marchaim D, Perez F, Lee J, et al. Swimming in resistance: Co-colonization with carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii or Pseudomonas aeruginosa. Am J Infect Control. 2012; 40 (9): 830–835. DOI: 10.1016/j.ajic.2011.10.013.
14. Timofte D, Dan M, Maciuca IE, et al. Emergence of concurrent infections with colistin-resistant ESBL-positive Klebsiella pneumoniae and OXA-23-producing Acinetobacter baumannii sensitive to colistin only in a Romanian cardiac intensive care unit. Eur J Clin Microbiol Infect Dis. 2015; 34 (10): 2069–2074. DOI: 10.1007/s10096–015–2453–3.
15. Chan AP, Choi Y, Brinkac LM, et al. Multidrug resistant pathogens respond differently to the presence of co-pathogen, commensal, probiotic and host cells. Sci Rep. 2018; 8 (1): 8656. DOI: 10.1038/s41598–018–26738–1.
16. Bjarnsholt T. The role of bacterial biofilms in chronic infections. APMIS. 2013; 136: 1–51. DOI: 10.1111/apm.12099.
17. Radlinski L, Rowe SE, Kartchner LB, et al. Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus. PLoS Biol. 2017; 15 (11): e2003981. DOI: 10.1371/journal.pbio.2003981.
18. Chebotar’ I.V., Bocharova Yu.A., Podoprigora I. V., Shagin D. A. Pochemu Klebsiella pneumoniae stanovitsya lidiruyushchim opportunisticheskim patogenom. Klinicheskaya mikrobiologiya i antimikrobnaya himioterapiya. 2020; 1: 4–19. DOI: 10.36488/cmac.
Review
For citations:
Gabrielyan N.I., Kormilitsina V.G., Kurbanova M.Kh., Esenova N.M., Sharapchenko S.O., Saitgareev R.Sh., Zakharevich V.M., Kisil O.V., Maleev V.V. Simultaneous colonization by gram-negative hospital pathogens. Medical alphabet. 2020;(34):13-16. (In Russ.) https://doi.org/10.33667/2078-5631-2020-34-13-16
Views:
241
Email this article 