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Витамин D, менопауза и возраст: чего ожидать? (Обзор литературы)

https://doi.org/10.33667/2078-5631-2020-26-30-36

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Аннотация

Менопауза и старение связаны с изменениями уровня гонадных стероидных гормонов, чувствительности к инсулину, массы тела, а также образа жизни и социальных координат. Витамин D влияет на различные метаболические процессы, помимо кальций-фосфорного и костного метаболизма. Основным маркером крови, используемым для измерения эндогенного витамина D, является 25-гидроксивитамин D. Старение связано с повышением содержания паратиреоидного гормона и щелочной фосфатазы в сыворотке крови, а также снижением содержания кальция, фосфора и метаболитов витамина D. На состояние 25-гидроксивитамина D также влияет круглогодичный ритм солнечного облучения. Результаты клинических ассоциативных исследований не коррелировали с интервенционными исследованиями, экспериментальными исследованиями и (или) метаанализами, касающимися роли витамина D в различных исходах у женщин в течение второй половины жизни, а также дозы витамина D, необходимой для улучшения клинических симптомов. Противоречивые результаты были связаны с методом, используемым для измерения витамина D, изучаемой популяцией (то есть социодемографией и этнической принадлежностью), проектами исследований и тенденциозностью анализа. Добавки витамина D, холекальциферола или кальцифедиола могут улучшить некоторые метаболические и клинические исходы у женщин в постменопаузе и пожилых. Исследования, по-видимому, предполагают, что кальцифедиол может иметь некоторые преимущества перед другими формами добавок витамина D.

Об авторах

Я. З. Зайдиева
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»
Россия

д.м.н., проф., рук. отделения гинекологической эндокринологии

г. Москва



В. Е. Балан
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»
Россия

д.м.н., проф., рук. поликлинического отделения

г. Москва



А. В. Царькова
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»
Россия

врач поликлинического отделения

г. Москва



Е. В. Кручинина
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»
Россия

к.м.н., н.с. отделения гинекологической эндокринологии

г. Москва



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Для цитирования:


Зайдиева Я.З., Балан В.Е., Царькова А.В., Кручинина Е.В. Витамин D, менопауза и возраст: чего ожидать? (Обзор литературы). Медицинский алфавит. 2020;(26):30-36. https://doi.org/10.33667/2078-5631-2020-26-30-36

For citation:


Zaydieva Y.Z., Balan V.E., Tsar’kova A.V., Kruchinina E.V. Витамин D, менопауза и возраст: чего ожидать? (Обзор литературы). Medical alphabet. 2020;(26):30-36. (In Russ.) https://doi.org/10.33667/2078-5631-2020-26-30-36

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ISSN 2078-5631 (Print)