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Dynamics of glomerular filtration rate indicators and cystatin C in patients with dyslipidemia on background of obesity in simvastatin treatment

https://doi.org/10.33667/2078-5631-2020-27-25-27

Abstract

Purpose of research. To evaluate changes in the filtration capacity of the kidneys and the functional state of the epithelium of the proximal renal tubules in patients with dyslipidemia during simvastatin therapy. Materials and methods. The study involved 86 people. All subjects were divided into three groups: a group of practically healthy individuals (14 men and 16 women), a comparison group (11 men and 16 women), the main group (14 subjects), were persons suffering from type 2 diabetes (DM2) (7 men and 7 women), and 15 subjects without DM2 (5 men and 10 women). Patients in the main group were prescribed simvastatin at a daily dose of 20 mg for 3 months. Treatment of patients in the main group, in addition to the appointment of simvastatin, was carried out according to clinical recommendations for the diagnosis and treatment of chronic heart failure and type 2 diabetes. Conclusions. 1. Simvastatin in a daily dose of 20 mg is effective when taking it for the purpose of correcting dyslipidemia, while in patients who do not suffer from type 2 diabetes, the improvement of all indicators of the lipid spectrum is statistically significant. 2. Receiving simvastatin for 3 months at a dose of 20 mg per day does not affect performance of the filtration ability of the kidneys in patients with dyslipidemia associated with obesity, but observed a statistically significant increase in the concentration of cystatin C in the urine specimen, which indicates the worsening degeneration of the proximal tubular epithelium in patients with early stage CHF without DM2 and in the background of the current DM2.

About the Authors

V. Yu. Kopylov
Orenburg State Medical University
Russian Federation
Orenburg


Yu. N. Kopylov
Orenburg State Medical University
Russian Federation
Orenburg


N. E. Artyomova
Orenburg State Medical University
Russian Federation
Orenburg


B. T. Turmuhambetova
Orenburg State Medical University
Russian Federation
Orenburg


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Review

For citations:


Kopylov V.Yu., Kopylov Yu.N., Artyomova N.E., Turmuhambetova B.T. Dynamics of glomerular filtration rate indicators and cystatin C in patients with dyslipidemia on background of obesity in simvastatin treatment. Medical alphabet. 2020;(27):25-27. (In Russ.) https://doi.org/10.33667/2078-5631-2020-27-25-27

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ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)