Early signs of hypertension-mediated brain damage: case report and possibilities of citicoline
https://doi.org/10.33667/2078-5631-2020-19-24-28
Abstract
Cognitive impairment (CI) are the main clinical symptom of hypertension-mediated brain damage and are present at the earliest stages of the disease. Classification of CI and clinical approach for patients with hypertension and CI are presented. A case report of a typical patient with hypertension and mild CI and their treatment is described. Evidence based management of CI with citicoline is discussed.
About the Authors
Т. М. Ostroumova
First Moscow State Medical University n.a. I.M. Sechenov
Russian Federation
Moscow
Russian Federation
Moscow
О. D. Ostroumova
First Moscow State Medical University n.a. I.M. Sechenov; Russian Medical Academy for Postgraduate Continuous Education
Russian Federation
Moscow
Russian Federation
Moscow
О. V. Golovina
Russian Medical Academy for Postgraduate Continuous Education
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Бойцов С.А., Баланова Ю. А., Шальнова С. А., Деев А. Д., Артамонова Г. В., Гатагонова Т. М. и др. Артериальная гипертония среди лиц 25–64 лет: распространенность, осведомленность, лечение и контроль. По материалам исследования ЭССЕ. Кардиоваскулярная терапия и профилактика. 2014; 13 (4): 4–14. [Boytsov S. A., Balanova Yu.A., Shalnova S. A., Deev A. D., Artamonova G. V., Gatagonova T. M. et al. Arterial hypertension among individuals of 25–64 years old: prevalence, awareness, treatment and control. By the data from ECCD. Cardiovascular Therapy and Prevention. 2014; 13 (4): 4–14. (In Russ.)]. https://doi.org/10.15829/1728-8800-2014-4-4-14
2. 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal. 2018; 00: 1–98. https://doi.org/10.1093/eurheartj/ehy339
3. Яхно Н.Н., Захаров В. В., Локшина А. Б., Коберская Н. Н., Мхитарян Э. А. Деменции. Руководство для врачей. М.: МедПрессинформ; 2011. 272 с. [Yakhno NN, Zakharov VV, Lokshina AB, Koberskaya NN, Mkhitaryan EA. Dementia. A guide for doctors. Moscow: MedPress-Inform; 2011. 272 p. (In Russ.)].
4. Парфенов В. А. Сосудистые когнитивные нарушения и хроническая ишемия головного мозга (дисциркуляторная энцефалопатия). Неврология, нейропсихиатрия, психосоматика. 2019; 11 (Прил. 3): 61–67. [Parfenov VA Vascular cognitive impairment and chronic cerebral ischemia (dyscirculatory encephalopathy). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019; 11 (3S): 61–67. (In Russ.)]. https://doi.org/10.14412/2074-2711-2019-3S-61-67
5. Коберская Н.Н., Остроумова Т. М. Доумеренное когнитивное снижение. Неврология, нейропсихиатрия, психосоматика. 2020; 12 (2): 92–97 [Koberskaya N.N., Ostroumova T. M. Near-moderate cognitive decline. Neurology, Neuropsychiatry, Psychosomatics. 2020; 12 (2): 92–97. (In Russ.)]. https://doi.org/10.14412/2074-2711-2020-2-92-97
6. Gorelick PB, Scuteri A, Black SE, DeCarli C, Greenberg SM, Iadecola C et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association. American Stroke Association. Stroke. 2011; 42 (9): 2672–2713. https://doi.org/10.1161/STR.0b013e3182299496
7. Остроумова Т.М., Остроумова О.Д., Парфенов В.А. Ранние признаки поражения головного мозга как органа-мишени при артериальной гипертензии. Неврология, нейропсихиатрия, психосоматика. 2019; 11 (3S): 32–37. [Ostroumova T. M., Ostroumova O. D., Parfenov V. A. Early signs of damage to the brain as a target organ in hypertension. Neurology, Neuropsychiatry, Psychosomatics. 2019; 11 (3S): 32–37. (In Russ.)]. https://doi.org/10.14412/2074-2711-2019-3S-32-37
8. Парфенов ВА, Остроумова ТМ, Остроумова ОД, Павлеева ЕЕ. Особенности клинической картины у пациентов среднего возраста с эссенциальной артериальной гипертензией. Терапевтический архив. 2018; 90 (9): 15–26 [Parfenov VA, Ostroumova TM, Ostroumova OD, Pavleyva EE. Features of the clinical picture in patients of middle age with essential hypertension. Terapevticheskii Arkhiv. 2018; 90 (9): 15–26 (In Russ.)]. https://doi.org/10.26442/terarkh201890915-26
9. Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C et al. Antihypertensive medications and risk for incident dementia and Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies. Lancet Neurol. 2020; 19 (1): 61–70. https://doi.org/10.1016/S1474-4422(19)30393-X
10. Kavirajan H, Schneider LS. Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol. 2007; 6(9): 782–792. https://doi.org/10.1016/S1474-4422(07)70195-3
11. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev. 2005; (2): CD 000269. https://doi.org/10.1002/14651858.CD000269.pub2
12. Lee HJ, Kang JS, Kim YI. Citicoline protects against cognitive impairment in a rat model of chronic cerebral hypoperfusion. J Clin Neurol. 2009; 5 (1): 33–38. https://doi.org/10.3988/jcn.2009.5.1.33
13. Secades JJ. Citicoline in the treatment of cognitive impairment. J Neurol Exp Neurosci. 2019; 5 (1): 14–26. https://doi.org/10.17756/jnen.2019-047
14. Alvarez-Sabín J, Ortega G, Jacas C, Santamarina E, Maisterra O, Ribo M et al. Longterm treatment with citicoline may improve poststroke vascular cognitive impairment. Cerebrovasc Dis. 2013; 35 (2): 146–154. https://doi.org/10.1159/000346602
15. Cotroneo AM, Castagna A, Putignano S, Lacava R, Fantò F, Monteleone F et al. Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study. Clin Interv Aging. 2013; 8: 131–137. https://doi.org/10.2147/CIA.S38420
16. Alvarez-Sabin J, Santamarina E, Maisterra O, Jacas C, Molina C, Quintana M. Longterm treatment with citicoline prevents cognitive decline and predicts a better quality of life after a first ischemic stroke. Int J Mol Sci. 2016; 17 (3): 390. https://doi.org/10.3390/ijms17030390
Review
For citations:
Ostroumova Т.М., Ostroumova О.D., Golovina О.V. Early signs of hypertension-mediated brain damage: case report and possibilities of citicoline. Medical alphabet. 2020;1(19):24-28. (In Russ.) https://doi.org/10.33667/2078-5631-2020-19-24-28
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