Current trends in analytical determination of vitamin D
https://doi.org/10.33667/2078-5631-2020-5-54-58
Abstract
Measurement of vitamin D has increased significantly in recent years. Most studies focused on 25(OH)D, which is considered the best indicator of vitamin D status, while there is now more interest in the combined measurement of several clinically significant vitamin D metabolites using the LC–MS/MS technique, which allows simultaneous determination of various vitamin D metabolites over a wide dynamic range. Multi-panel LC–MS/MS analyses are likely to improve future research on the optimal combination of metabolites to assess vitamin D sufficiency, as well as help us better understand its metabolism in normal and pathological changes in the human body. The review examines current trends in analytical determination of vitamin D status and their application in clinical studies.
About the Authors
S. V. Khabarov
Tula State University; Federal Scientific and Clinical Centre for Specialized Medical Care and Medical Technologies; VITROMED Co.
Russian Federation
Tula; Moscow
Russian Federation
Tula; Moscow
N. A. Vislotskiy
Tula State University
Russian Federation
Tula
Russian Federation
Tula
O. V. Denisova
Federal Scientific and Clinical Centre for Specialized Medical Care and Medical Technologies; DiaLab+ Co.
Russian Federation
Moscow
Russian Federation
Moscow
D. G. Navasardyants
DiaLab+ Co.
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Khabarov S.V., Vislotskiy N.A., Denisova O.V., Navasardyants D.G. Current trends in analytical determination of vitamin D. Medical alphabet. 2020;(5):54-58. (In Russ.) https://doi.org/10.33667/2078-5631-2020-5-54-58
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