Assessment of quality of markers of myocardial damage using sigmametry

Abstract

The purpose. To evaluate study quality markers of myocardial damage using Sigmametry.

Materials and methods. The study was conducted in a Federal Centre for Cardiovascular Surgery. Data were collected in 2017–2018. Daily there controlled the following indicators: high-sensitivity troponin T, myoglobin, the MB fraction of creatine phosphokinase. The study was performed on an automatic immunochemical electrochemiluminescence analyzer cobas e411. The sigmametry values were calculated using CV (coefficient of variation), systematic error (bias), and total analytical error (TE_max).

Results. The analysis of the quality of laboratory studies using the calculation of sigma values in 2017 revealed: sigma values less than 4 are noted in the study of the second level of the control material for highly sensitive troponin T, at the same time in the study of the first level of the control material sigma values more than 4 and amounted to 6.26. Analysis of the quality of laboratory studies in 2018, showed the following: the values of sigma is less than 4 it is noted in the study of the first level of the control material at a fraction of MB – creatine phosphokinase, at the same time in the study of level 2 control material values of sigma greater than 4, and amounted to 4.14.

Conclusions. Оn the basis of sigmametry (calculation of sigma values) changes in the tactics of intralaboratory analysis were held, what allowed to improve the quality of laboratory studies.