Parameters of cytokine balance and vascular-epithelial growth factor depending on level of vitamin D in patients with external genital endometriosis
https://doi.org/10.33667/2078-5631-2020-4-55-58
Abstract
The study was performed to find association between some cytokine status indicators, level of vascular endothelial growth factors and vitamin D in women with infertility and external genital endometriosis (EGE) in order to increase the effectiveness of its treatment. The low vitamin D status in the dynamics was determined in 240 patients aged 25 to 35 years with EGE planning pregnancy by determining the level of 25 (OH) D in the blood serum using the chemiluminescent method. Interleukin status (IL-1β, IL-6, IL-4), TNF-α, VEGFR-1 in blood serum was determined using enzyme-multiple immunoassay. The results of the studies revealed an increased level of IL-6, IL-1β and TNF-α in groups with low vitamin D content. In normal vitamin D significantly lower levels of vascular endothelial growth factor (VEGFR-1 ) in the blood serum were registered. Pregnancy rates were higher in groups with normal 25(OH)D levels in the blood serum. The mean serum VEGFR-1 level in pregnant women who became pregnant on their own was 1.3–1.5 times lower.
About the Authors
S. R. Akhmedova
Dagestan State Medical University
Russian Federation
Russian Federation
Makhachkala
N. S.-M. Omarov
Dagestan State Medical University
Russian Federation
Russian Federation
Makhachkala
References
1. Адамян Л. В., Андреева Е. Н., Аполихина И. А., и др. Эндометриоз: Диагностика, лечение и реабилитация. Федеральные клинические рекомендации по ведению больных. М.: РОАГ; 2016.
2. Ярмолинская М. И., Айламазян Э. К. Генитальный эндометриоз. Различные грани проблемы. СПб.: Эко-Вектор; 2017.
3. Demir R., Yaba A., Huppertz B. Vasculogenesis and angiogenesis in the endometrium during menstrual cycle and implantation // Acta Histochem. 2010. Vol. 112. P. 203–14. doi:10.1016/j.act-his.2009.04.004.
4. Laschke M. W., Giebels C., Menger M. D. Vasculogenesis: a new piece of the endometriosis puzzle // Hum. Reprod. Update. 2011. Vol. 17(5). P. 628–36. doi: 10.1093/humupd/dmr023.
5. Radzinskiy V. E., Orazov M. R., Nosenko E. N. Expression of vascular endothelial growth factor (VEGF) in uterine tissues as one of the mechanisms of algogenezis in adenomyosis, associated with chronic pelvic pain // Patologycheskaya physiologiya i eksperimentalnaya terapiya. 2016. Vol. 1. P. 32–35.
6. Российская Ассоциация Эндокринологов. Дефицит витамина Д у взрослых: диагностика, лечение и профилактика: клинические рекомендации. М.: Эндокринологический научный центр; 2015.
7. Almassinokiani F., Khodaverdi S., Solaymani-Dodaran M., et al. Effects of vitamin D on endometriosis-related pain: a double-blind clinical trial // Med SciMonit. 2016. Vol. 22. P. 4960–4966.
8. Pike J. W., Meyer M. B. The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D 3 // Rheum Dis Clin North Am. 2012. Vol. 38. P. 13–27. https://doi.org/10.1016/j.ecl.2010.02.007
9. Денисова А. С., Ярмолинская М. И. Роль витамина D в патогенезе генитального эндометриоза // Журнал акушерства и женских болезней. 2017. Т. 66(6). С. 81–88.
10. Merhi Z., Doswell A., Krebs K., et al. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells // J Clin Endocrinol Metab. 2014. Vol. 99 (6). P. 1137–1145.
11. Delvin E., Souberbielle J. C., Viard J. P., et al. Role of vitamin D in acquired immune and autoimmune diseases // Crit Rev Clin Lab Sci. 2014. Vol. 51. P. 232–247.
12. Irani M., Seifer D. B., Grazi R. V., et al. Vitamin D supplementation decreases TGF-β1 bioavailability in PCOS: a randomized placebo-controlled trial // J Clin Endocrinol Metab. 2015. Vol. 100(11). P. 4307–4314.
13. Paffoni A., Ferrari S., Viganò P., et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles // J Clin Endocrinol Metab. 2014. Vol. 99. E 2372 - E 2376. https://doi.org/10.1210/jc.2014-1802
14. Cöl-Madendag I., Madendag Y., Altinkaya S. Ö., et al. The role of VEGF and its receptors in the etiology of early pregnancy loss //Gynecol. Endocrinol. 2014. Vol. 30(2). P. 153–156.
15. Волкова Л. В., Аляутдина О. С. Клинико-диагностическое значение сосудисто эндотелиального фактора роста при неудачных попытках ЭКО //Акушерство и гинекология. 2011. № 4. С. 126–129.
16. Gysemans C. A., Cardozo A. K., Callewaert H. et al. 1,25-Dihydroxyvitamin D 3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice // Endocrinology. 2014. Vol. 146 (4). P. 1956–1964.
17. Бурлев В. А. Пролиферативная и ангиогенная активность эндометриоидных кист яичника // Проблемы репродукции. 2016. № 3. С. 91–100.
18. Герилович Л. А., Салмина А. Б. и др. Роль маркеров ангиогенеза у пациенток с различными формами бесплодия в программах репродуктивных технологий // Проблемы репродукции. 2013. № 5. С. 60–63.
Review
For citations:
Akhmedova S.R., Omarov N.S. Parameters of cytokine balance and vascular-epithelial growth factor depending on level of vitamin D in patients with external genital endometriosis. Medical alphabet. 2020;(4):55-58. (In Russ.) https://doi.org/10.33667/2078-5631-2020-4-55-58
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