Status of microbiota of vaginal tract in women with premature birth (clinical and anamnestic features)

Abstract

In order to study the characteristics of the obstetric and gynecological history in women with preterm birth and to identify the most significant factors affecting premature termination of pregnancy, 297 cases of preterm birth were analyzed for a period of 22 to 37 weeks of gestation. In the group with preterm birth, statistically significantly more common were women with a history of miscarriage (31.4 %; p = 0.003), with a high parity of childbirth (more than three) (14.8 %; p = 0.0024), with overweight body and obesity of varying severity (37.3 %; p = 0.0012), anemia (58.9 %; p = 0.003), neck diseases with surgical treatment (17.1 %; p = 0.003), nonspecific vaginitis (18.2 %; p = 0.004), bacterial vaginosis (26.3 %; p = 0.002) and abnormalities of the uterus (4.0 %; p = 0.04). Pregnancy was most often complicated by placental insufficiency (63.6 %; p = 0.001), the threat of termination (59.2 %; p = 0.001), amniotic fluid pathology (37 %; p = 0.002) and preeclampsia (22.2 %; p = 0.024). 67 % of patients were noted with preterm birth, dysbiosis of the vaginal tract of varying severity.