Comprehensive study of number and types of saturated and polyunsaturated fatty acids in composition of preparations
https://doi.org/10.33667/2078-5631-2019-4-33(408)-15-24
Abstract
When prescribing a vitamin‑mineral complex or a drug containing docosahexaenoic acid (DHA) to a pregnant, lactating mother and child, it is expected to receive the effect from the subsidy of this polyunsaturated fatty acid (omega‑3 PUFA). In the case when the preparation contains additional impurities, the magnitude and nature of the effect may differ from the expected ones. In this work, we conducted a comprehensive study of the composition of 11 omega‑3 PUFA preparations with chromatographic determination of more than 40 metabolites of fatty acids and other compounds. The obtained data on the composition of the extracts were analyzed using modern methods of intellectual analysis. As a result, quantitative markers were obtained that made it possible to separate preparations based on standardized omega‑3 PUFAs from less standardized ones based on chromatographic analysis of the fatty acid composition of the preparations: marker ‘EPA + DHA’, marker ‘ω6 + ω11’ and standardization coefficient evaluating the conformity of measured levels of omega‑3 PUFAs to manufacturer declared. Based on the data obtained, highly standardized (Elevit Feeding, Omacor), medium and low standardized preparations were selected. It is recommended to take these data into account when prescribing and choosing vitamin complexes for nursing women, preferring highly standardized ones.
About the Authors
O. A. Gromova
Federal Research Centre ‘The Informatics and Management’; Moscow State University n. a. M. V. Lomonosov
Russian Federation
Moscow
Russian Federation
Moscow
I. Yu. Torshin
Federal Research Centre ‘The Informatics and Management’; Moscow State University n. a. M. V. Lomonosov
Russian Federation
Moscow
Russian Federation
Moscow
B. Ts. Zaychik
Federal Research Centre ‘The Fundamentals of Biotechnology’
Russian Federation
Moscow
Russian Federation
Moscow
A. O. Ruzhitsky
Federal Research Centre ‘The Fundamentals of Biotechnology’
Russian Federation
Moscow
Russian Federation
Moscow
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For citations:
Gromova O.A., Torshin I.Yu., Zaychik B.Ts., Ruzhitsky A.O. Comprehensive study of number and types of saturated and polyunsaturated fatty acids in composition of preparations. Medical alphabet. 2019;4(33):15-24. (In Russ.) https://doi.org/10.33667/2078-5631-2019-4-33(408)-15-24
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