Is 2-phenoxyethanol safe when used in medicine and cosmetics?
https://doi.org/10.33667/2078-5631-2019-3-32(407)-41-43
Abstract
This article discusses issues related to the use of the preservative 2-phenoxyethanol in medicine and cosmetology. The scope of this substance in various types of medical, pharmaceutical and cosmetic products, its presence in nature, in plants such as avocados, green tea, is described. The physical properties of 2-phenoxyethanol and its mechanism of action are considered. It substantiates its content in goods in disinfectants and skin antiseptics (2 %) and perfumes and cosmetics (1 %). Potential safety issues with this substance are discussed. The absence of irritating effects on the skin, the absence of allergic reactions to the mucous membrane of the eyes, the absence of contact allergies and photosensitization, the absence of toxicity and hemolytic effect have been shown.
References
1. ifrafragrance.org/initiatives/transparency/ifratransparency-list.
2. Технический регламент Таможенного союза о безопасности парфюмерно-косметической продукции ТР ТС 009/2011.
3. www.drugbank.ca/drugs/DB 11304.
4. Рейнольдс JEF, Прасад AB (ред.) Мартиндейл — Экстра Фармакопея. 28-е изд. London: The Pharmaceutical Press, 1982, p. 1288.
5. Budavari S. (ed.). The Merck Index — Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989, p. 1153.
6. toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~uxkhoj:1:phcy.
7. grls.rosminzdrav.ru/default.aspx.
8. RIFM (Research Institute for Fragrance Materials Inc.), 1987a. Emery’s submission to EPA of test data on 2-phenoxyethanol. Unpublished report from Emery Chemicals. Report number 18899 (RIFM, Woodcliff Lake, NJ, USA).
9. C. R. Lovell, I. R. White, J. Boyle. Contact dermatitis from phenoxyethanol in aqueous cream bp Contact Dermatitis, 11 (1984), p. 187.
10. K. W. Frolich, L. M. Andersen, A. Knutsen, P. P. Flood Phenoxyethanol as a nontoxic substitute for formaldehyde in long-term preservation of human anatomical specimens for dissection and demonstration purposes The Anatomical Record, 208 (1984), pp. 271–278.
11. RIFM (Research Institute for Fragrance Materials Inc.), 1978a. Acute toxicity studies in rats, mice, rabbits, and guinea pigs. RIFM report number 1699, October 03 (RIFM, Woodcliff Lake, NJ, USA).
12. J. Geier, H. Lessmann, H. Dickel, P. J. Frosch, P. Koch, D. Becker, U. Jappe, W. Aberer, A. Schnuch, W. UterPatch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG) Contact Dermatitis, 51 (3) (2004), pp. 118–130.
13. RIFM (Research Institute for Fragrance Materials Inc.), 1987a. Emery’s submission to EPA of test data on 2-phenoxyethanol. Unpublished report from Emery Chemicals. Report number 18899 (RIFM, Woodcliff Lake, NJ, USA).
14. www.rifm.org/rifm-science-database.php.
15. RIFM (Research Institute for Fragrance Materials Inc.), 1984a. Kodak’s submission to EPA of test data on 2-phenoxyethanol. Unpublished report from Eastman Kodak Company. Report number 7157 (RIFM, Woodcliff Lake, NJ, USA).
16. RIFM (Research Institute for Fragrance Materials Inc.), 1978a. Acute toxicity studies in rats, mice, rabbits, and guinea pigs. RIFM report number 1699, October 03 (RIFM, Woodcliff Lake, NJ, USA.
17. H. F. Smyth, J. Seaton, J. L. Fischer The single dose toxicity of some glycols and derivatives J. Ind. Hyg. Toxicol., 23 (6) (1941), pp. 259–268.
18. B. H. Scortichini, J. F. Quast, K. S. RaoTeratologic evaluation of 2-phenoxyethanol in New Zealand white rabbits following dermal exposure Fundam. Appl. Toxicol., 8 (2) (1987), pp. 272–279.
19. W. J. Breslin, J. E. Phillips, L. G. Lomax, M. J. Bartels, D. A. Dittenber, L. L. Calhoun, R. R. Miller Hemolytic activity of ethylene glycol phenyl ether (EGPE) in rabbits Fundam. Appl. Toxicol., 17 (3) (1991), pp. 466–481.
20. D. Maron, J. Katzenellenbogen, B. N. AmesCompatibility of organic solvents with the salmonella/microsome test Mutat. Res.-Reviews Mutat. Res., 88 (1981), pp. 343–350.
21. www.oecd-ilibrary.org/environment/test-no-471-bacterial-reverse-mutation-test_9789264071247-en.
Review
For citations:
Melnikova O.A. Is 2-phenoxyethanol safe when used in medicine and cosmetics? Medical alphabet. 2019;3(32):41-43. (In Russ.) https://doi.org/10.33667/2078-5631-2019-3-32(407)-41-43
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