Enzymes from carbohydrase group destroy biofilm matrix of gram-positive and gram-negative bacteria
https://doi.org/10.33667/2078-5631-2019-4-34(409)-40-45
Abstract
The effect of enzymes carbohydrases exopolysaccharide matrix of biofilms formed by gram-positive and gram-negative bacteria on abiotic surfaces was studied. The ability of a mixture of carbohydrase enzymes (hydrolases and lyases) to completely destroy the matrix of biofilms formed by gram-positive and gram-negative bacteria causing health-associated infections has been confirmed. An optimal mixture of carbohydrases possesed high anti-biofilm activity even when employed in relatively small concentrations and at a brief exposure time.
About the Authors
Yu. M. Romanova
National Research Centre for Epidemiology and Microbiology n. a. Honorary Academician N. F. Gamaleya
Russian Federation
Moscow
Russian Federation
Moscow
A. V. Tutelyan
Central Research Institute of Epidemiology; Federal Research and Clinical Centre for Pediatric Hematology, Oncology and Immunology n. a. Dmitry Rogachyov; First Moscow State Medical University n. a. I. M. Sechenov
Russian Federation
Moscow
Russian Federation
Moscow
A. P. Sinitsyn
Moscow State University n. a. M. V. Lomonosov
Russian Federation
Moscow
Russian Federation
Moscow
V. M. Pisarev
Federal Scientific and Clinical Centrе fоr Reanimatology and Rehabilitation; Federal Research and Clinical Centre for Pediatric Hematology, Oncology and Immunology n. a. Dmitry Rogachyov
Russian Federation
Lytkino, Moscow Region; Moscow
Russian Federation
Lytkino, Moscow Region; Moscow
N. V. Alekseeva
National Research Centre for Epidemiology and Microbiology n. a. Honorary Academician N. F. Gamaleya
Russian Federation
Moscow
Russian Federation
Moscow
N. I. Filipova
National Research Centre for Epidemiology and Microbiology n. a. Honorary Academician N. F. Gamaleya
Russian Federation
Moscow
Russian Federation
Moscow
E. R. Tolordava
National Research Centre for Epidemiology and Microbiology n. a. Honorary Academician N. F. Gamaleya
Russian Federation
Moscow
Russian Federation
Moscow
O. A. Sinitsyna
Moscow State University n. a. M. V. Lomonosov
Russian Federation
Moscow
Russian Federation
Moscow
O. V. Emshanov
BFR Laboratories Co.
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Romanova Yu.M., Tutelyan A.V., Sinitsyn A.P., Pisarev V.M., Alekseeva N.V., Filipova N.I., Tolordava E.R., Sinitsyna O.A., Emshanov O.V. Enzymes from carbohydrase group destroy biofilm matrix of gram-positive and gram-negative bacteria. Medical alphabet. 2019;4(34):40-45. (In Russ.) https://doi.org/10.33667/2078-5631-2019-4-34(409)-40-45
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