Clinical case of pulmonary embolism in a patient with eosinophilic phenotype of chronic obstructive pulmonary disease

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality in the world. Exacerbations of COPD is considered an independent risk factor for pulmonary embolism (PE). PE is also significant problem of modern medicine, because mortality in PE remains at a high level. Exacerbations of COPD are heterogeneous as by etiology as by phenotype of the inflammatory response. It is presents the clinical case of PE in patient with acute exacerbation of COPD with eosinophilic phenotype of inflammation. It was the presence of a floating venous thrombus in the patient, which could become a source of repeated PE at any time. The patient underwent endovascular intervention — thrombus fragmentation and thromboaspiration. Given the signs of eosinophilic inflammation, systemic glucocorticosteroids have also been prescribed. The result of the intervention was a regression of respiratory failure and pulmonary hypertension.