Diagnosis of connective tissue dysplasia in patients with celiac disease

Abstract

Justification. There is information about the adverse effects of connective tissue dysplasia (DST) on the development, course and prognosis of diseases of various organs and systems. In recent years, much attention has been paid to hereditary diseases of the digestive organs, among which celiac disease is isolated. The widespread presence of CT in the digestive organs determine the adverse course of the pathology of the gastrointestinal tract (GIT) in the DST. In this regard, of particular interest is the study of the combined course of DST and celiac disease. Purpose of the study. The study of the frequency and structure of external and visceral stigmas of disembriogenesis, their influence on the course of celiac disease and their contribution to the development of comorbidity. Methods. 90 patients aged from 18 to 67 years old were examined with a verified diagnosis of celiac disease. The survey included an analysis of clinical and anamnestic data, the results of laboratory and instrumental studies. Screening for the identification of signs of disambiogenesis was based on the Russian National Recommendations (2012). The research materials were processed in the Statistica application, Microsoft Excel. Results. According to the severity of symptoms of DST, the patients with celiac disease were divided into 3 groups: 1 st with mild severity - 32 people (35.5 %); 2nd with an average degree of severity - 37 (41.1 %); 3rd with severe DST - 21 (23.3 %). The increase in the frequency of occurrence of flat-stop, Gothic palate, diaphragmatic hernia, gallbladder anomaly, and tracheobronchial dyskinesia (p < 0.051) corresponded to the increase in the degree of DST. In patients of the 3rd group, signs of dysfunction of the sphincter apparatus of the upper GI tract, biliary tract and increased asthenia were diagnosed more often than in patients of the 1st and 2nd groups. Conclusion. In celiac disease, there is a high level of stigmatization of symptoms of disembriogenesis, coupled with the severity of DST, which causes a variety of clinical manifestations, systemic disorders and contributes to the unfavorable prognosis and course of the underlying disease.