Expression of receptors of steroid hormones and vitamin D in reducing mineral density of bone tissue caused by acid diseases of stomach

Relevance. Currently, the proven relationship with the state of the upper gastrointestinal tract with changes in the mineral density of bone tissue. It is known that hormonal regulation plays a key role in the background of complicated gastroduodenal pathology. Its action on target organs hormones mediate through specific receptors, however the level of expression of receptors of steroid hormones and vitamin D in acid-related diseases of the stomach and with concomitant metabolic bone remains not enough investigated. The goal is to study the content of steroid hormone receptors and vitamin D in the duodenal mucosa in patients of different age groups with acid-related diseases of the stomach and changes in the mineral density of bone tissue. Methodology the study included two groups of men with acid-related diseases in age from 23 to 54 years (mean age 30 years) and aged 55 to 80 years (mean age 59 years). All patients underwent histological examination of mucosal 12 duodenal ulcer, immunohistochemical study of the receptors ER-a, ER-β, PR, AR, DR and glucocorticoids, hormones and vitamin D in the blood, the study of mineral bone density (BMD). The results and their analysis. In patients with reduced BMD and pathology of the organ's gastrointestinal tract (pathology was detected more than 20 years ago), vitamin D receptors (74 %), AR and Erfi-receptors, were predominantly found in gastro-biopsy specimens of the duodenum. In young patients with osteopenic syndrome (OPS) and gastrointestinal tract diseases in the duodenal mucosa, on the contrary, high expression of PR and glucocorticoid receptors is revealed, which allows treating the duodenum as the target organ for the action of these hormones. High expression of glucocorticoid receptors in the studied biopsies confirms their active role in the realization of their inherent biological effects. Presence of progesterone receptors in goblet cells and an increase in their expression in rescuers with a reduced BMD indicates the unconditional participation of progesterone in the pathogenesis of OPS formation. It is possible that PR perform a protective function. Conclusion. Especially the expression of hormone receptors in combined pathology of the digestive tract and reducing the IPC mechanisms of all these processes require further study.

steroid hormone receptors, acid-related diseases of the stomach, osteopenic syndrome

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