Signs of prethrombosis in patients with coronary artery disease and hypertension who underwent coronary artery bypass grafting

Abstract

In troduction. Patients who had coronary artery bypass surgery are at high risk for shunt thrombosis. Objective of the study is to determine the role of hypertension in combination with other factors in causing the state of thrombotic preparedness in patients who had coronary artery bypass surgery. Materials and methods. 69 patients suffering from arterial hypertension and atherosclerotic cardiovascular disease who had coronary artery bypass surgery were examined. All patients underwent a study of the content of fibrinogen, von Willebrand factor, induced platelet aggregation and lupus anticoagulant in the blood on the 12th day after the surgery. Results. It was detected that long-term increase in arterial blood pressure, degree of increase in diastolic blood pressure and smoking caused the progression of state of thrombotic preparedness. The detection of circulating lupus anticoagulant after coronary artery bypass surgery did not depend on long-term increase in arterial blood pressure and its degree, but it was connected with myocardial infarction which patiens had previously. The degree of arterial sclerotic disease of coronary artery in patients suffering from arterial hypertension correlated with long-term increase in arierial blood pressure. Conclusion. Long-standing history of arterial hypertension and high diastolic blood pressure can cause the state of thrombotic preparedness at the early postoperative period after coronary artery bypass surgery.