Early vascular aging syndrome in young and middle age patients with hypertension and coronary artery disease

Abstract

Purpose. To determine the frequency of early vascular aging syndrome (EVA- syndrome) occurrence in young and middle age patients with hypertension and coronary artery disease (CAD). Materials and methods. The study involved 59 young and middle age (52 [46.5; 55.0], years) patients (men) with hypertension level of 1-3 in combination with stable angina pectoris 1^tt-3^rd class. The anamnestic data, results of coronary angiography, metabolic parameters, ultrasound of the heart and brachiocephalic arteries, relative telomere length, direct and indirect indices of vascular wall stiffness were evaluated. Results. EVA-syndrome was detected in 43 (72.9 %) patients with hypertension in combination with CAD. Patients were divided into subgroups depending on EVA-syndrome presence or absence. Two independent statistically significant predictors of EVA-syndrome - cardio-ankle vascular index (CAVI) (p = 0.011) and shortened telomeres (p = 0.035) were revealed. Increase of CAVI by one unit increases the EVA-syndrome chances of at 5.09 [1.78; 24.37] times, compared with patients with median values of all predictors included in the optimal model. The presence of shortened telomeres increases the chances of EVA-syndrome at60.69 [3.31; 8481.46] times. Conclusion. Independent predictors of EVA-syndrome in young and middle age patients with hypertension and CAD as CAVI and the shortened telomeres presence are revealed, the latter increase the probability syndrome presence.