Rheumatoid arthritis and interstitial lung diseases: modern approaches to therapy
https://doi.org/10.33667/2078-5631-2026-12-49-56
Abstract
Interstitial lung disease (ILD) is the most severe extra-articular manifestation of rheumatoid arthritis (RA) and one of the most frequent causes of death in these patients. Treatment of ED in RA is still a subject of debate. Ideally, it should be aimed at controlling the activity of joint pathology, preventing healing or slowing the progression of lung damage, in particular fibrotic changes. Antirheumatic drugs that modify the course of RA are used in daily practice, but their effectiveness in ILD has not been proven, although good control of systemic disease can improve the prognosis for patients. Immunosuppressants, which are commonly recommended for the treatment of ILD associated with immune-inflammatory rheumatic disease, often have low efficacy against RA. Therefore, in order to determine the optimal therapeutic strategy for a particular patient, an interdisciplinary discussion is usually required, including at least a rheumatologist and a pulmonologist. This article will review the currently available RA-ILD treatment options, with an emphasis on their possible use in accordance with current knowledge about the pathogenesis and clinical development of this disease.
About the Authors
B. S. Belov
V. A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Belov Boris S., Dr Med Sci (habil.), head of the Laboratory of Rheumatoid Arthritis and Comorbid Infections
N. V. Muravyeva
V. A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Muravyeva Natalia V., PhD Med Sc, Senior Researcher at Laboratory of Rheumatoid Arthritis and Comorbid Infections
M. A. Sedelnikova
V. A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Sedelnikova Marija A., physician of the 3rd Rheumatology Dept.
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Belov B.S., Muravyeva N.V., Sedelnikova M.A. Rheumatoid arthritis and interstitial lung diseases: modern approaches to therapy. Medical alphabet. 2026;(12):49-56. (In Russ.) https://doi.org/10.33667/2078-5631-2026-12-49-56
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