Skin melanoma. Modern perspectives in complex treatment
https://doi.org/10.33667/2078-5631-2026-8-12-18
Abstract
Melanoma of the skin is an extremely aggressive malignancy characterized by high mortality and frequent relapses. In recent years, revolutionary changes have occurred in the treatment of this disease. The introduction of targeted therapy and immunotherapy into clinical practice has significantly changed the traditionally unfavorable prognosis for many patients, including patients with unresectable tumors. However, despite the existing progress, the response to existing therapy is observed not in all cases. Together with the growing incidence, this emphasizes the need for the development of new therapeutic approaches and further studies aimed at assessing their efficacy and safety. This review summarizes the long-term results of large studies that have already influenced clinical guidelines and highlights new promising areas that may change medical practice in the near future.
About the Authors
A. I. Ponyrko
I. M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Ponyrko Arina I., student
Moscow
P. V. Golubev
A. F. Tsyba Medical Radiology Research Center – branch of the National Medical Research Radiology Center
Russian Federation
Russian Federation
Golubev Pavel V., PhD Med Sci, oncologist at Dept of Antitumor Drug Therapy
Obninsk
E. S. Kuzmina
S. S. Yudin City Clinical Hospital of the Moscow Department of Health
Russian Federation
Russian Federation
Kuzmina Evgeniya S., PhD Med Sci, head of Chemotherapy Dept No. 2 of Oncology Center No. 1
Moscow
V. M. Kuzmin
I. M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Kuzmin Vladislav M., student
Moscow
S. A. Golubeva
P. A. Herzen Moscow Cancer Research Institute – branch of the National Medical Research Radiology Center
Russian Federation
Russian Federation
Golubeva Sofia A., oncologist at Dept of Combined Treatment Methods No. 1
Moscow
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Review
For citations:
Ponyrko A.I., Golubev P.V., Kuzmina E.S., Kuzmin V.M., Golubeva S.A. Skin melanoma. Modern perspectives in complex treatment. Medical alphabet. 2026;(8):12-18. (In Russ.) https://doi.org/10.33667/2078-5631-2026-8-12-18
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