Basic and extended cardiopulmonary resuscitation in children – recommendations 2025
https://doi.org/10.33667/2078-5631-2026-11-14-19
Abstract
Modern international guidelines for cardiopulmonary resuscitation (CPR) increasingly emphasize an individualized, physiologically oriented approach to managing patients after cardiac arrest. The updated protocols for advanced life support in children by the European Resuscitation Council (ERC PALS, 2025) confirm the key role of high-quality CPR as the basis for a successful outcome. It emphasizes the importance of maintaining an optimal frequency and depth of chest compressions, minimizing interruptions, and preventing hyperventilation. At the same time, attention is shifting to achieving target physiological parameters, primarily diastolic pressure (≥25 mmHg in infants and ≥30 mmHg in children over one year of age) and end-tidal carbon dioxide concentration (ETCO2) as markers of CPR effectiveness. A number of innovations concern the timing and sequence of adrenaline administration, the priority of rapid defibrillation in shock rhythms, and the management of the post-resuscitation period, where the main focus has been on actively preventing hyperthermia (maintaining a temperature of ≤37.5 °C) and maintaining blood pressure above the 10th percentile for age. The new data highlights the need for a multifactorial neurological prediction that does not rely on a single isolated test. Thus, the new guidelines from the American Heart Association and the American Academy of Pediatrics (AHA/AAP) aim to improve the effectiveness of CPR, personalize post-resuscitation care, and enhance long- term neurological outcomes in pediatric patients.
About the Authors
O. Yu. PopovRussian Federation
Popov Oleg Yu., PhD Med Sci, associate professor at Dept of Disaster Medicine, associate professor, acting head of Dept of Emergency and Tactical Medicine, Medical Institute, Director
Moscow; Kaluga
V. A. Mitish
Russian Federation
Mitish Valery A., PhD Med Sci, associate professor, head of Dept of Disaster Medicine, head of Dept of Wounds and Wound Infections
Moscow
M. A. Borodina
Russian Federation
Borodina Maria A., Dr Med Sci (habil.), professor at Dept of Disaster Medicine
Moscow
O. K. Yusupov
Russian Federation
Yusupov Odildzhon K., employee
Kaluga
A. A. Misinchuk
Russian Federation
Misinchuk Andrey A., employee
Kaluga
Y. V. Kvyatkovskiy
Russian Federation
Kvyatkovskiy Yaroslav V., laboratory assistant at Dept of Emergency Medical Care, Faculty of Medicine
Moscow
References
1. Mathias J. Holmberg, MD, MPH, Sebastian Wiberg, MD, PhD, Catherine E. Ross, MD, Monica Kleinman, MD, Anne Kirstine Hoeyer-Nielsen, BSc, Michael W. Donnino, MD, and Lars W. Andersen, MD, MPH, PhD, DMSc Trends in Survival After Pediatric In-Hospital Cardiac Arrest in the United States). https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041667
2. Salim S. Virani, MD, PhD, FAHA, Chair, Alvaro Alonso, MD, PhD, FAHA, Emelia J. Benjamin, MD, ScM, FAHA, Marcio S. Bittencourt, MD, PhD, MPH, Clifton W. Callaway, MD, FAHA, April P. Carson, PhD, MSPH, FAHA, Alanna M. Chamberlain Heart Disease and Stroke Statistics‑2020 Update: A Report From the American Heart Association https://www.ahajournals.org/doi/10.1161/CIR.0000000000001370#R6
3. Jana Djakow Nigel McBeth Turnerd Sophie Skellett∙Inge Roggenp Dominique Biarent European Resuscitation Council Guidelines 2025 Paediatric Life Support https://www.resuscitationjournal.com/article/S0300–9572(25)00279–5/fulltext
4. Joyner BL, Dewan M, Bavare A, de Caen A, DiMaria K, Donofrio-Odmann J, Fosse G, Haskell S, Mahgoub M, Meckler G, Requist J, Schexnayder SM, Olech Smith M, Werho D, Raymond TT. Part 6: pediatric basic life support: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. https://cpr.heart.org/en/resuscitation-science/cpr-and-ecc-guidelines/pediatric-basic-life-support?#4r6
5. R. Lubranoa∙ C. Cecchettid, ∙ E. Bellellia ∙ S. Rugolottof, g ∙ N. Pirozzid ∙ M. Elli Comparison of times of intervention during pediatric CPR maneuvers using ABC and CAB sequences: A randomized trial. https://doi.org/10.1016/j.resuscitation.2012.04.011
6. Huda M Ashoor, Erin Lillie, Wasifa Zarin, Ba’ Pham, Paul A Khan, Vera Nincic, Fatemeh Yazdi, Marco Ghassemi, John Ivory, Roberta Cardoso, Gavin D Perkins, Allan R de Caen, Andrea C Tricco. Effectiveness of different compression-to-ventilation methods for cardiopulmonary resuscitation: A systematic review. PMID: 28583860 DOI: 10.1016/j.resuscitation.2017.05.032. https://pubmed.ncbi.nlm.nih.gov/28583860/
7. Ian G Jacobs, Judith C Finn, Harry F Oxer, George A Jelinek CPR before defibrillation in out-of-hospital cardiac arrest: A randomized trial. https://onlinelibrary.wiley.com/doi/10.1111/j.1742–6723.2005.00694.x
8. Delphine Lavignasse ∙ Sabine Lemoine ∙ Sarah Ménétré ∙ Jean-Philippe Didon ∙ Daniel Jost ∙ Xavier Jouven Improved survival to hospital discharge in paediatric in-hospital cardiac arrest using 2 Joules/kilogram as first defibrillation dose for initial pulseless ventricular arrhythmia. DOI: 10.1016/j.resuscitation.2020.09.042. https://www.resuscitationjournal.com/article/S0300–9572(20)30566–9/fulltext
9. Energy doses for paediatric defibrillation in cardiac arrest: systematic review and meta-analysis., Jason Acworth et al., Resusc Plus. 2025 (ILCOR review). DOI: 10.1016/j.resplu.2025.100991
10. Delphine Lavignasse Sabine Lemoine Sarah Ménétré Jean-Philippe Didon Daniel Jost Xavier Jouven Improved survival to hospital discharge in paediatric in-hospital cardiac arrest using 2 Joules/kilogram as first defibrillation dose for initial pulseless ventricular arrhythmia. DOI: 10.1016/j.resuscitation.2020.09.042. https://www.resuscitationjournal.com/article/S0300–9572(20)30566–9/fulltext
11. Matthew L. Hansen ∙ Amber Lina ∙ Carl Eriksson ∙ Dana Zive ∙ Craig Newgard A comparison of pediatric airway management techniques during out-of-hospital cardiac arrest using the CARES database. DOI: 10.1016/j.resuscitation.2017.08.015 https://www.resuscitationjournal.com/article/S0300–9572(17)30342–8/abstract
12. Association Between Tracheal Intubation During Pediatric In-Hospital Cardiac Arrest and Survival. JAMA Published Online: November 1, 20162016; 316; (17): 1786–1797. doi:10.1001/jama.2016.14486. https://jamanetwork.com/journals/jama/fullarticle/2565184
13. Lin YR, Li CJ, Huang CC, Lee TH, Chen TY, Yang MC, et al. Early Epinephrine Improves the Stabilization of Initial Post-resuscitation Hemodynamics in Children With Non-shockable Out-of-Hospital Cardiac Arrest. Front Pediatr. 2019;7:220. DOI: 10.3389/fped.2019.00220. https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2019.00220/full
14. Andersen LW, Berg KM, Saindon BZ, et al. Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest. JAMA. 2015; 314 (8): 802–810. DOI: 10.1001/jama.2015.9678
15. Topjian AA, Berg RA, Nadkarni VM, et al. Hemodynamic-directed cardiopulmonary resuscitation in pediatric cardiac arrest: rationale and evidence. Pediatrics. 2017; 139 (3): e20162657. DOI: 10.1542/peds.2016–2657
16. Wang HE, Seitz SR, Sulzbach KL, et al. Epinephrine absorption and hemodynamic effects during endotracheal administration in pediatric cardiac arrest. Resuscitation. 2011; 82 (10): 1349–1354. DOI: 10.1016/j.resuscitation.2011.05.020
17. Berg RA, Sutton RM, Reeder RW, et al. Association Between Diastolic Blood Pressure During Pediatric CPR and Return of Spontaneous Circulation. Circulation. 2019; 139 (25): 2881–2891. DOI: 10.1161/CIRCULATIONAHA.118.039320
18. Valdes SO, Donoghue AJ, Hoyme DB, et al. Outcomes Associated With Delayed Defibrillation in Pediatric In-Hospital Cardiac Arrest. Circulation. 2014; 130 (6): 469–476. DOI: 10.1161/CIRCULATIONAHA.113.008248
19. Topjian AA, Berg RA, Nadkarni VM, et al. Pediatric Defibrillation: A Review of Safety, Efficacy, and Energy Dose. Resuscitation. 2013; 84 (3): 299–305. DOI: 10.1016/j.resuscitation.2012.10.019
20. Moler FW, Silverstein FS, Holubkov R, et al. Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children. NEJM. 2015; 372: 1898–1908. DOI: 10.1056/NEJMoa141148
21. Meaney PA, Bobrow BJ, Mancini ME, et al. CPR quality: improving cardiac resuscitation outcomes both inside and outside the hospital. Circulation. 2013; 128 (4): 417–435. DOI: 10.1161/CIRCULATIONAHA.113.001168
22. Cheskes S, Schmicker RH, Christenson J, et al. Compression interruption during prehospital defibrillation and survival in ventricular fibrillation cardiac arrest. Circulation. 2011; 124 (6): 58–66. DOI: 10.1161/CIRCULATIONAHA.110.006595
23. Atkins DL, Berger S, Duff JP, et al. Pediatric defibrillation: current status and recommendations. Circulation. 2006; 114 (25): 2760–2773. DOI: 10.1161/CIRCULATIONAHA.106.633618
24. Topjian AA, Berg RA, Nadkarni VM, et al. Pediatric Defibrillation: Energy Dose, Electrode Placement, and Outcomes. Resuscitation. 2013; 84 (3): 299–305. DOI: 10.1016/j.resuscitation.2012.10.019
25. Berg RA, Sutton RM, Reeder RW, et al. Association Between Diastolic Blood Pressure During Pediatric CPR and Return of Spontaneous Circulation. Circulation. 2019; 139 (25): 2881–2891. DOI: 10.1161/CIRCULATIONAHA.118.039320
26. Topjian AA, Berg RA, Donoghue AJ, et al. Association of End-Tidal Carbon Dioxide With Outcomes in Pediatric In-Hospital Cardiac Arrest. Circulation. 2012; 126 (22): 2626–2633. DOI: 10.1161/CIRCULATIONAHA.112.119256
27. Schultz TR, White RD, Stohr EJ, et al. End-tidal carbon dioxide as an early indicator of return of spontaneous circulation during pediatric cardiac arrest. Resuscitation. 2013; 84 (10): 1397–1402. DOI: 10.1016/j.resuscitation.2013.03.005
28. Topjian AA, Schleien CL, Nadkarni VM, et al. Low end-tidal CO2 during pediatric CPR is associated with poor survival. Pediatric Critical Care Medicine. 2010; 11 (2): 154–160. DOI: 10.1097/PCC.0b013e3181b5d041
29. Barton ED, Colwell CB, Wolfe T, et al. Efficacy of intranasal naloxone as a needleless alternative for treatment of opioid overdose in the prehospital setting. Journal of Emergency Medicine. 2005; 29 (3): 265–271. DOI: 10.1016/j.jemermed.2005.03.007
30. Kerr D, Dietze P, Kelly AM, et al. Randomized controlled trial comparing intranasal and intramuscular naloxone for the treatment of suspected heroin overdose. Addiction. 2009; 104 (12): 2067–2074. DOI: 10.1111/j.1360–0443.2009.02724.x
31. Tobias JD. Naloxone use in children. Pediatrics. 1996; 98 (5): 1065–1066.
32. Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children. New England Journal of Medicine. 2015; 372: 1898–1908. DOI: 10.1056/NEJMoa1411480
33. Moler FW, Silverstein FS, Holubkov R, et al. Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. New England Journal of Medicine. 2017; 376: 318–329. DOI: 10.1056/NEJMoa1610493
34. Topjian AA, Berg RA, Nadkarni VM, et al. Early postresuscitation hypotension is associated with increased mortality following pediatric cardiac arrest. Critical Care Medicine. 2014; 42 (6): 1518–1523. DOI: 10.1097/CCM.0000000000000216
Review
For citations:
Popov O.Yu., Mitish V.A., Borodina M.A., Yusupov O.K., Misinchuk A.A., Kvyatkovskiy Y.V. Basic and extended cardiopulmonary resuscitation in children – recommendations 2025. Medical alphabet. 2026;1(11):14-19. (In Russ.) https://doi.org/10.33667/2078-5631-2026-11-14-19
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