Evaluation of the impact of nutritional correction using the biologically active food supplement “Zinc chelate” in preventive programs aimed at increasing individual viability

Zinc has been shown to have a positive effect on recovery from pneumonia, colds, and diarrhea. There is also evidence of a link between low zinc levels and the severity of the novel coronavirus infection, leading to active study of its use as a non-specific prophylaxis and adjuvant therapy for COVID-19. The most pronounced effect of zinc supplementation is expected in individuals with subclinical or severe zinc deficiency. Due to the high incidence of zinc deficiency and its significant contribution to a wide range of pathologies, zinc deficiency correction is an economically feasible intervention. Nutrition correction using the Zinc Chelate dietary supplement increases resistance to acute respiratory viral infections, alleviates their course, and improves the convalescence period; improvement of the immune locus of the vital domain of intrinsic viability has pleiotropic effects on the aesthetic domain of intrinsic viability.

1. Kumssa D.B., Joy E.J., Ander E.L. et al. Dietary calcium and Zinc deficiency risks are decreasing but remain prevalent. Sci Rep. 2015 Jun 22; 5: 10974. https://doi.org/10.1038/srep10974

2. Gupta S., Brazier A.K.M., Lowe N.M. Zinc deficiency in low- and middle-income countries: prevalence and approaches for mitigation. J Hum Nutr Diet. 2020 Oct; 33(5): 624–643. Epub 2020 Jul 6. https://doi.org/10.1111/jhn.12791

3. Lassi Z.S., Moin A., Bhutta Z.A. Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months. Cochrane Database Syst Rev. 2016 Dec 4; 12(12): CD005978. https://doi.org/10.1002/14651858.CD005978.pub3

4. Mayo-Wilson E., Junior J.A., Imdad A. et al. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Cochrane Database Syst Rev. 2014 May 15; (5): CD009384. https://doi.org/10.1002/14651858.CD009384.pub2

5. Yakoob M.Y., Theodoratou E., Jabeen A. et al. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health. 2011 Apr 13; 11 Suppl 3 (Suppl 3): S23. https://doi.org/10.1186/1471-2458-11-S3-S23

6. Kim B, Lee WW. Regulatory Role of Zinc in Immune Cell Signaling. Mol Cells. 2021 May 31; 44 (5): 335–341. DOI: 10.14348/molcells.2021.0061

7. Bonaventura P, Benedetti G, Albarède F, Miossec P. Zinc and its role in immunity and inflammation. Autoimmun Rev. 2015 Apr; 14 (4): 277–85. DOI: 10.1016/j.autrev.2014.11.008

8. Wang L., Song Y. Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: A meta-analysis of randomized, doubleblind and placebo-controlled trials. Clin Respir J. 2018 Mar; 12 (3): 857–864. https://doi.org/10.1111/crj.12646. Epub 2017 May 31. PMID: 28488366.

9. Mousavi S.M., Djafarian K., Mojtahed A. et al. The effect of zinc supplementation on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials. Eur J Pharmacol. 2018 Sep 5; 834: 10–16. https://doi.org/10.1016/j.ejphar.2018.07.019

10. Hemilä H, Fitzgerald JT, Petrus EJ, Prasad A. Zinc Acetate Lozenges May Improve the Recovery Rate of Common Cold Patients: An Individual Patient Data Meta-Analysis. Open Forum Infect Dis. 2017 Apr 3; 4 (2): ofx059. DOI: 10.1093/ofid/ofx059. PMID: 28480298; PMCID: PMC5410113.

11. Skalny A.V., Rink L., Ajsuvakova O.P. et al. Zinc and respiratory tract infections: perspectives for COVID-19 (Review). Int J Mol Med. 2020 Jul; 46 (1): 17–26. Epub 2020 Apr 14. https://doi.org/10.3892/ijmm.2020.4575

12. Kodentsova V.M., Pogozheva A.V. Risk groups for multiple vitamin and mineral defi-ciencies in the population. Clinical nutri-tion and metabolism. 2020; 1(3): 34–40. DOI: 10.17816/clinutr48744 (in Russ.).

13. Gandia P, Bour D, Maurette JM, Donazzolo Y, Duchène P, Béjot M, Houin G. A bioavailability study comparing two oral formulations containing zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers. Int J Vitam Nutr Res. 2007 Jul; 77 (4): 243–8. DOI: 10.1024/0300-9831.77.4.243. PMID: 18271278.

14. Tokarczyk J, Koch W. Dietary Zn-Recent Advances in Studies on Its Bioaccessibility and Bioavailability. Molecules. 2025 Jun 25; 30 (13): 2742. DOI: 10.3390/molecules30132742. PMID: 40649260; PMCID: PMC12251316.