Профилактический и лечебный потенциал дентабиотиков при патологии пародонта и сопутствующих заболеваниях кишечника и печени

Микробиота полости рта оказывает определенное влияние на развитие и течение гастроэнтерологических заболеваний, в частности, неалкогольной жировой болезни печени и воспалительных заболеваний кишечника. Подтверждением концепции «пародонтальной медицины» и двунаправленной взаимосвязи заболеваний пародонта и соматических заболеваний является наличие эффекта от лечения одного заболевания, который сопровождается позитивным влиянием на другое заболевание. В первой части обзора рассмотрено влияние нехирургического парадонтологического лечения на течение неалкогольной жировой болезни печени и воспалительных заболеваний кишечника. Во второй части обзора рассмотрены возможности использования пробиотиков как дополнительного компонента нехирургического парадонтологического лечения. Пробиотики, применяемые для коррекции нарушений микробиоценоза и поддержания нормальной микрофлоры полости рта, называются дентабиотиками. Рассмотрены состав и терапевтические возможности компонентов двух дентабиотиков компании «БиоМэджик» позволяющие предполагать наличие профилактического и лечебного потенциала дентабиотиков при патологии пародонта и сопутствующих заболеваниях кишечника и печени по оси «рот–кишечник–печень». Возможное позитивное влияние дентабиотиков на микробиоту верхних дыхательных путей и ЛОР-органов позволяет рассматривать их в качестве дентаоробиотиков – пробиотиков для коррекции нарушений микробиоценоза и поддержания нормальной микрофлоры полости рта, верхних дыхательных путей и ЛОР-органов.

1. Williams R. C., Offenbacher S. Periodontal medicine: The emergence of a new branch of periodontology. Periodontology 2000. 2000; 23: 9–12. https://doi.org/10.1034/j.1600-0757.2000.2230101.x

2. Pai SI, Matheus HR, Guastaldi FPS. Effects of periodontitis on cancer outcomes in the era of immunotherapy. Lancet Healthy Longev. 2023 Apr; 4 (4): e166–e175. https://doi.org/10.1016/S2666-7568 (23) 00021‑1

3. Трухан Д. И., Сулимов А. Ф., Трухан Л. Ю. Ассоциация артериальной гипертензии и патологии пародонта: обзор новых данных. Фарматека. 2023; 30 (9–10): 40–51. https://doi.org/10.18565/pharmateca.2023.9-10.40-51

4. Трухан Д. И., Сулимов А. Ф., Трухан Л. Ю. Коморбидность артериальной гипертензии и пародонтита: стоматологическая гипертензия. Клинический разбор в общей медицине. 2023; 4 (6): 62–68. https://doi.org/10.47407/kr2023.4.5.00273

5. Клинические рекомендации. Сахарный диабет 2 типа у взрослых. 2022. Одобрено Научно-практическим советом Минздрава РФ. URL: https://cr.minzdrav.gov.ru/recomend/290_2

6. Трухан Д. И., Сулимов А. Ф., Трухан Л. Ю. Сахарный диабет и заболевания пародонта: вместе или параллельно? Фарматека. 2024; 31 (6): 16–22. https://doi.org/10.18565/pharmateca.2024.6.16-22

7. Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, Herrera D, Jepsen S, Lione L, Madianos P, Mathur M, Montanya E, Shapira L, Tonetti M, Vegh D. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International diabetes Federation and the European Federation of Periodontology. Diabetes Res Clin Pract. 2018 Mar; 137: 231–241. https://doi.org/10.1016/j.diabres.2017.12.001

8. Лазебник Л. Б., Дехнич Н. Н., Ситкин С. И., Атрушевич В. Г., Авалуева Е. Б. и др. Helicobacter pylori, хеликобактериоз и ассоциированные заболевания (VIII Московские соглашения по диагностике и лечению хеликобактериоза у взрослых и детей). Руководство для врачей. Экспериментальная и клиническая гастроэнтерология. 2024; (12): 49–145. https://doi.org/10.31146/1682–8658-ecg-232-12-49-145

9. Furusho H., Miyauchi M., Hyogo H., Inubushi T., Ao M., Ouhara K., Hisatune J., Kurihara H., Sugai M., Hayes C. N., Nakahara T., Aikata H., Takahashi S., Chayama K, Takata T. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice. J. Gastroenterol. 2013; 48: 1259–1270. https://doi.org/10.1007/s00535-012-0738-1

10. Altay U, Gurgan CA, Agbaht K. Changes in inflammatory and metabolic parameters after periodontal treatment in patients with and without obesity. J Periodontol. 2013; 84: 13–23. https://doi.org/10.1902/jop.2012.110646

11. Piconi S, Trabattoni D, Luraghi C, Perilli E, Borelli M, Pacei M, Rizzardini G, Lattuada A, Bray DH, Catalano M, Sparaco A, Clerici M.. Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness. FASEB J. 2009 Apr; 23 (4): 1196–204. https://doi.org/10.1096/fj.08-119578

12. Kim JY, Park YM, Lee GN, Song HC, Ahn YB, Han K, Ko SH. Association between toothbrushing and non-alcoholic fatty liver disease. PLoS One. 2021; 16: e0243686. https://doi.org/10.1371/journal.pone.0243686

13. Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, Murata S, Tohnai I, Sumida Y, Shima T, Kuboniwa M, Umemura K, Kamisaki Y, Amano A, Okanoue T, Ooshima T, Nakajima A. Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. BMC Gastroenterol. 2012; 12: 16. https://doi.org/10.1186/1471-230X-12-16

14. Kamata Y, Kessoku T, Shimizu T, Sato S, Kobayashi T, Kurihashi T, Morozumi T, Iwasaki T, Takashiba S, Hatanaka K, Hamada N, Kodama T, Higurashi T, Taguri M, Yoneda M, Usuda H, Wada K, Nakajima A, Minabe M. Periodontal Treatment and Usual Care for Nonalcoholic Fatty Liver Disease: A Multicenter, Randomized Controlled Trial. Clin Transl Gastroenterol. 2022; 13: e00520. https://doi.org/10.14309/ctg.0000000000000520

15. Newman KL, Kamada N. Pathogenic associations between oral and gastrointestinal diseases. Trends Mol Med. 2022 Dec; 28 (12): 1030–1039. https://doi.org/10.1016/j.molmed.2022.05.006

16. Koutsochristou V, Zellos A, Dimakou K, Panayotou I, Siahanidou S, Roma-Giannikou E, Tsami A. Dental Caries and Periodontal Disease in Children and Adolescents with Inflammatory Bowel Disease: A Case-Control Study. Inflamm Bowel Dis. 2015 Aug; 21 (8): 1839–46. https://doi.org/10.1097/MIB.0000000000000452

17. Lorenzo-Pouso AI, Castelo-Baz P, Rodriguez-Zorrilla S, Pérez-Sayáns M, Vega P. Association between periodontal disease and inflammatory bowel disease: a systematic review and meta-analysis. Acta Odontol Scand. 2021 Jul; 79 (5): 344–353. https://doi.org/10.1080/00016357.2020.1859132

18. Baima G, Muwalla M, Testa G, Mazza F, Bebars A, Perotto S, Vernero M, Massano A, Romano F, Ribaldone DG, Aimetti M. Periodontitis prevalence and severity in inflammatory bowel disease: A case-control study. J Periodontol. 2023 Mar; 94 (3): 313–322. https://doi.org/10.1002/JPER.22-0322

19. Ивашкин В. Т., Маев И. В., Абдулганиева Д. И., Алексеенко С. А., Горелов А. В. и др. Практические рекомендации Научного сообщества по содействию клиническому изучению микробиома человека (НСОИМ) и Российской гастроэнтерологической ассоциации (РГА) по применению пробиотиков, пребиотиков, синбиотиков и обогащенных ими функциональных пищевых продуктов для лечения и профилактики заболеваний гастроэнтерологического профиля у детей и взрослых. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021; 31 (2): 65–91. https://doi.org/10.22416/1382-4376-2021-31-2-65-91

20. Трухан Д. И. Нарушения кишечного микробиоценоза: расширение сферы применения пробиотиков. Медицинский совет. 2022; 16 (7): 132–143. https://doi.org/10.21518/2079-701X-2022-16-7-132-143

21. Baddouri L, Hannig M. Probiotics as an adjunctive therapy in periodontitis treatment-reality or illusion-a clinical perspective. NPJ Biofilms Microbiomes. 2024 Dec 16; 10 (1): 148. https://doi.org/10.1038/s41522-024-00614-5

22. O'Donnell R, Holliday R, Jakubovics N, Benfield E. Methods used to deliver adjunctive probiotic treatment during the non-surgical management of periodontitis: A scoping review. J Dent. 2025 Apr; 155: 105623. https://doi.org/10.1016/j.jdent.2025.105623

23. Salah AN, Doghish YA, Abbass SO, Mansour RM, Sayed GA, Elshami NH, Mageed SSA, Mohammed OA, Abulsoud AI, Zaki MB, Mosalam EM, Elrebehy MA, Alfarsi K, Doghish AS. Microbiota-based therapies in oral health and disorders.Folia Microbiol (Praha). 2025 Dec; 70 (6): 1217–1240. https://doi.org/10.1007/s12223-025-01324-x

24. Matsubara VH, Bandara HM, Ishikawa KH, Mayer MP, Samaranayake LP. The role of probiotic bacteria in managing periodontal disease: a systematic review. Expert Rev Anti Infect Ther. 2016 Jul; 14 (7): 643–55. https://doi.org/10.1080/1478 7210.2016.1194198

25. Sharma H, Ruikar M, Verma S. Probiotic Supplementation for Periodontal Diseases – An Umbrella Review. Indian J Dent Res. 2024 Nov 28. https://doi.org/10.4103/ijdr.ijdr_905_23. Online ahead of print.

26. Puzhankara L, Banerjee A, Chopra A, Venkitachalam R, Kedlaya MN. Effectiveness of probiotics compared to antibiotics to treat periodontal disease: Systematic review. Oral Dis. 2024 Jul; 30 (5): 2820–2837. https://doi.org/10.1111/odi.14781

27. Hu D, Zhong T, Dai Q. Clinical efficacy of probiotics as an adjunctive therapy to scaling and root planning in the management of periodontitis: a systematic review and meta-analysis of randomized controlled trails. J Evid Based Dent Pract. 2021 Jun; 21 (2): 101547. https://doi.org/10.1016/j.jebdp.2021.101547

28. Yu X, Devine DA, Vernon JJ. Manipulating the diseased oral microbiome: the power of probiotics and prebiotics. J Oral Microbiol. 2024 Jan 31; 16 (1): 2307416. https://doi.org/10.1080/20002297.2024.2307416

29. Bustamante M, Oomah BD, Mosi-Roa Y, Rubilar M, Burgos-Díaz C. Probiotics as an Adjunct Therapy for the Treatment of Halitosis, Dental Caries and Periodontitis. Probiotics Antimicrob Proteins. 2020 Jun; 12 (2): 325–334. https://doi.org/10.1007/s12602-019-9521-4

30. Mishra S, Rath S, Mohanty N. Probiotics-A complete oral healthcare package. J Integr Med. 2020 Nov; 18 (6): 462–469. https://doi.org/10.1016/j.joim.2020.08.005

31. Horz H. P., Meinelt A., Houben B., Conrads G. Distribution and persistence of probiotic Streptococcus salivarius K12 in the human oral cavity as determined by real-time quantitative polymerase chain reaction. Oral. Microbiol. Immunol. 2007; 22 (2): 126–130. https://doi.org/10.1111/j.1399-302X.2007.00334.x

32. Di Pierro F, Adami T, Rapacioli G, Giardini N, Streitberger C. Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults. Expert Opin Biol Ther. 2013 Mar; 13 (3): 339–43. https://doi.org/10.1517/14712598.2013.758711

33. Burton JP, Cowley S, Simon RR, McKinney J, Wescombe PA, Tagg JR. Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: a randomized, placebo-controlled, double-blind study. Food Chem Toxicol. 2011 Sep; 49 (9): 2356–64. https://doi.org/10.1016/j.fct.2011.06.038

34. Di Pierro F, Risso P, Poggi E, Timitilli A, Bolloli S, Bruno M, Caneva E, Campus R, Giannattasio A. Use of Streptococcus salivarius K12 to reduce the incidence of pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. Minerva Pediatr. 2018 Jun; 70 (3): 240–245. https://doi.org/10.23736/S0026-4946.18.05182

35. Stašková A, Sondorová M, Nemcová R, Kačírová J, Maďar M. Antimicrobial and Antibiofilm Activity of the Probiotic Strain Streptococcus salivarius K12 against Oral Potential Pathogens. Antibiotics (Basel). 2021 Jun 29; 10 (7): 793. https://doi.org/10.3390/antibiotics10070793

36. MacDonald KW, Chanyi RM, Macklaim JM, Cadieux PA, Reid G, Burton JP. Streptococcus salivarius inhibits immune activation by periodontal disease pathogens.BMC Oral Health. 2021 May 7; 21 (1): 245. https://doi.org/10.1186/s12903-021-01606-z

37. Yoo HJ, Jwa SK, Kim DH, Ji YJ. Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro. Clin Exp Dent Res. 2020 Apr; 6 (2): 207–214. https://doi.org/10.1002/cre2.269

38. Park JA, Lee GR, Lee JY, Jin BH. Oral Probiotics, Streptococcus salivarius K12 and M18, Suppress the Release of Volatile Sulfur Compounds and a Virulent Protease from Oral Bacteria: An In-Vitro Study.Oral Health Prev Dent. 2023 Aug 29; 21: 259–270. https://doi.org/10.3290/j.ohpd.b4328987

39. Babina K, Salikhova D, Polyakova M, Svitich O, Samoylikov R, Ahmad El-Abed S, Zaytsev A, Novozhilova N. The Effect of Oral Probiotics (Streptococcus Salivarius k12) on the Salivary Level of Secretory Immunoglobulin A, Salivation Rate, and Oral Biofilm: A Pilot Randomized Clinical Trial. Nutrients. 2022 Mar 7; 14 (5): 1124. https://doi.org/10.3390/nu14051124

40. Zupancic K, Kriksic V, Kovacevic I, Kovacevic D. Influence of Oral Probiotic Streptococcus salivarius K12 on Ear and Oral Cavity Health in Humans: Systematic Review. Probiotics Antimicrob Proteins. 2017 Jun; 9 (2): 102–110. https://doi.org/10.1007/s12602-017-9261-2

41. Трухан Д. И., Сулимов А. Ф., Трухан Л. Ю. Изменения органов и тканей полости рта при новой коронавирусной инфекции (COVID-19). Consilium Medicum. 2022; 24 (5): 349–357. https://doi.org/10.26442/20751753.2022.5.201755

42. Wescombe PA, Hale JD, Heng NC, Tagg JR. Developing oral probiotics from Streptococcus salivarius. Future Microbiol. 2012 Dec; 7 (12): 1355–71. https://doi.org/10.2217/fmb.12.113

43. Di Pierro F. A possible probiotic (S. salivarius K12) approach to improve oral and lung microbiotas and raise defenses against SARS-CoV-2. Minerva Med. 2020 Jun; 111 (3): 281–283. https://doi.org/10.23736/S0026-4806.20.06570-2

44. Di Pierro F, Colombo M. The administration of S. salivarius K12 to children may reduce the rate of SARS-CoV-2 infection. Minerva Med. 2021 Aug; 112 (4): 514–516. https://doi.org/10.23736/S0026-4806.21.07487-5

45. Sarlin S, Tejesvi MV, Turunen J, Vänni P, Pokka T, Renko M, Tapiainen T. Impact of Streptococcus salivarius K12 on Nasopharyngeal and Saliva Microbiome: A Randomized Controlled Trial. Pediatr Infect Dis J. 2021 May 1; 40 (5): 394–402. https://doi.org/10.1097/INF.0000000000003016

46. Laky B, Bruckmann C, Blumenschein J, Durstberger G, Haririan H. Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo-controlled clinical trial.J Periodontol. 2024 Feb; 95 (2): 101–113. https://doi.org/10.1002/JPER.23-0115

47. Ivanova I, Miteva V, Stefanova Ts, Pantev A, Budakov I, Danova S, Moncheva P, Nikolova I, Dousset X, Boyaval P. Characterization of a bacteriocin produced by Streptococcus thermophilus 81. Int J Food Microbiol. 1998 Jul 21; 42 (3): 147–58. https://doi.org/10.1016/s0168–1605 (98) 00067-1

48. Wang Y, Zhao H, Zhang H, Hou B, Hung W, He J, Liang C, Li B, Man C, Jiang Y, Zhang Y, Guo L. Metabolic and Transcriptomic-Based Characterization of Streptococcus salivarius ssp. thermophilus Snew Fermentation in Milk. Foods. 2025 Feb 6; 14 (3): 530. https://doi.org/10.3390/foods14030530

49. Трухан Д. И., Викторова И. А. Коррекция нарушений кишечного микробиоценоза в аспекте профилактики респираторных инфекций дыхательных путей: возможности Lactobacillus rhamnosus GG. Гастроэнтерология. Хирургия. Интенсивная терапия. Consilium Medicum. 2018; 2: 39–44. https://doi.org/10.26442/26583739.2018.2.180103

50. Naureen Z, Medori MC, Dhuli K, Donato K, Connelly ST, Bellinato F, Gisondi P, Bertelli M. Polyphenols and Lactobacillus reuteri in oral health.J Prev Med Hyg. 2022 Oct 17; 63 (2 Suppl 3): E 246–E 254. https://doi.org/10.15167/2421-4248/jpmh2022.63.2S3.2767

51. Mu Q, Tavella VJ, Luo XM. Role of Lactobacillus reuteri in Human Health and Diseases. Front Microbiol. 2018 Apr 19; 9: 757. https://doi.org/10.3389/fmicb.2018.00757

52. Yu Z, Chen J, Liu Y, Meng Q, Liu H, Yao Q, Song W, Ren X, Chen X. The role of potential probiotic strains Lactobacillus reuteri in various intestinal diseases: New roles for an old player. Front Microbiol. 2023 Feb 2; 14: 1095555. https://doi.org/10.3389/fmicb.2023.1095555

53. Martin-Cabezas R, Davideau JL, Tenenbaum H, Huck O. Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: a systematic review and meta-analysis. J Clin Periodontol. 2016 Jun; 43 (6): 520–30. https://doi.org/10.1111/jcpe.12545.

54. Ikram S, Hassan N, Baig S, Borges KJJ, Raffat MA, Akram Z. Effect of local probiotic (Lactobacillus reuteri) vs systemic antibiotic therapy as an adjunct to non-surgical periodontal treatment in chronic periodontitis.J Investig Clin Dent. 2019 May;10(2): e12393. https://doi.org/10.1111/jicd.12393

55. Song D, Liu XR. Role of probiotics containing Lactobacillus reuteri in adjunct to scaling and root planing for management of patients with chronic periodontitis: a meta-analysis.Eur Rev Med Pharmacol Sci. 2020 Apr; 24 (8): 4495–4505. https://doi.org/10.26355/eurrev_202004_21032

56. Vanditha D, BVR R, Chava VK, Biradavolu S, Nagarakanti S, Gunupati S. Modulatory Effect of Probiotic Fiber (Lactobacillus reuteri) in Residual Periodontal Pockets: A Randomized, Double-Blind, Placebo-Controlled Study. Cureus. 2025 Jan 14; 17 (1): e77413. https://doi.org/ 10.7759/cureus.77413

57. Teughels W, Durukan A, Ozcelik O, Pauwels M, Quirynen M, Haytac MC. Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol. 2013 Nov; 40 (11): 1025–35. https://doi.org/10.1111/jcpe.12155

58. Salinas-Azuceno C, Martínez-Hernández M, Maldonado-Noriega JI, Rodríguez-Hernández AP, Ximenez-Fyvie LA. Probiotic Monotherapy with Lactobacillus reuteri (Prodentis) as a Coadjutant to Reduce Subgingival Dysbiosis in a Patient with Periodontitis. Int J Environ Res Public Health. 2022 Jun 26; 19 (13): 7835. https://doi.org/10.3390/ijerph19137835

59. Wahba N, Sharaf D, Wagdy M, El-Motayam A, Nagi B. The potential bactericidal effect of oral probiotics on extrinsic black stain-associated bacteria in children: An in-vitro and in-vivo study. J Dent Sci. 2025 Oct; 20 (4): 2315–2321. https://doi.org/10.1016/j.jds.2025.04.032

60. Sachelarie L, Scrobota I, Romanul I, Iurcov R, Potra Cicalau GI, Todor L. Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach. Medicina (Kaunas). 2025 Jan 14; 61 (1): 126. https://doi.org/10.3390/medicina61010126

61. Голошубина В. В., Трухан Д. И., Багишева Н. В. Нарушения кишечного микробиоценоза: актуальные аспекты терминологии, клиники, профилактики. РМЖ. 2020; 12: 17–22. URL: https://www.elibrary.ru/item.asp?id=44807053

62. Huang X, Bao J, Yang M, Li Y, Liu Y, Zhai Y. The role of Lactobacillus plantarum in oral health: a review of current studies. J Oral Microbiol. 2024 Oct 22; 16 (1): 2411815. https://doi.org/10.1080/20002297.2024.2411815

63. Трухан Д. И., Гудилин В. А. Антибиотик-ассоциированная диарея: возможности применения синбиотиков. Фарматека. 2023; 30 (14): 32–39. https://doi.org/10.18565/pharmateca.2023.14.32-39

64. D'Agostino S, Valentini G, Iarussi F, Dolci M. Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review. Dent J (Basel). 2024 Apr 10; 12 (4): 102. https://doi.org/10.3390/dj12040102

65. Dong Y, Han M, Qi Y, Wu Y, Zhou Z, Jiang D, Gai Z. Enhancement of host defense against Helicobacter pylori infection through modulation of the gastrointestinal microenvironment by Lactiplantibacillus plantarum Lp05. Front Immunol. 2025 Jan 17; 15: 1469885. https://doi.org/10.3389/fimmu.2024.1469885

66. Fan Y, Dong Y, Gai Z, Zhang Y, Han M. Lactiplantibacillus plantarum Lp05 protects against ethanol-induced liver injury in zebrafish through metabolic and microbiota modulation. Sci Rep. 2025 Jul 2; 15 (1): 22584. https://doi.org/10.1038/s41598-025-07111-5

67. Wang L, Wang R, He Q, Hu Q, Yang J, Tang X. Assessment of the Effectiveness of Probiotics-assisted Physical Interventions in the Management of Chronic Periodontitis: A Randomized Controlled Clinical Trial.Probiotics Antimicrob Proteins. 2025 Dec; 17 (6): 4215–4223. https://doi.org/10.1007/s12602-024-10369-2

68. Cai Y, Dong Y, Han M, Jin M, Liu H, Gai Z, Zou K. Lacticaseibacillus paracasei LC 86 mitigates age-related muscle wasting and cognitive impairment in SAMP8 mice through gut microbiota modulation and the regulation of serum inflammatory factors. Front Nutr. 2024 May 30; 11: 1390433. https://doi.org/10.3389/fnut.2024.1390433

69. Chen T, Zhao Y, Fan Y, Dong Y, Gai Z. Genome sequence and evaluation of safety and probiotic potential of Lacticaseibacillus paracasei LC 86 and Lacticaseibacillus casei LC 89. Front Microbiol. 2025 Jan 27; 15: 1501502. https://doi.org/10.3389/fmicb.2024.1501502

70. Zhu J, Sun Y, Dong Y, Zhao Y, Gai Z, Fang S. Efficacy and Safety of Lactobacillus acidophilus LA85 in Preventing Antibiotic-Associated Diarrhea: A Randomized, Placebo-Controlled Study. Food Sci Nutr. 2025 Jun 20; 13 (6): e70490. https://doi.org/10.1002/fsn3.70490

71. Han M, Liao W, Dong Y, Fei T, Gai Z. Sustained ameliorative effect of Lactobacillus acidophilus LA85 on dextran sulfate sodium-induced colitis in mice. J Food Sci. 2023 Sep; 88 (9): 3893–3904. https://doi.org/10.1111/1750-3841.16723

72. Viana MDM, Silva Santos S, Bastos de Souza M, Opretzka LCF, Leite Lopes D, Pereira Soares MB, Villarreal CF. Lactobacillus acidophilus LA85 reverses experimental diabetic sensory neuropathy by restoring redox homeostasis in the spinal cord. Benef Microbes. 2025 Mar 28; 16 (5): 557–571. https://doi.org/10.1163/18762891-bja00069

73. Monteagudo-Mera A, Fanti V, Rodriguez-Sobstel C, Gibson G, Wijeyesekera A, Karatzas KA, Chakrabarti B. Gamma aminobutyric acid production by commercially available probiotic strains. J Appl Microbiol. 2023 Feb 16; 134 (2): lxac066. https://doi.org/10.1093/jambio/lxac066

74. Guo X, Guo A, Li E. Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium.Bioprocess Biosyst Eng. 2021 Feb; 44 (2): 235–246. https://doi.org/10.1007/s00449-020-02437-y

75. Rui W, Zhong S, Li X, Tang X, Wang L, Yang J. Evaluating the Role of Postbiotics in the Modulation of Human Oral Microbiota: A Randomized Controlled Clinical Trial. Probiotics Antimicrob Proteins. 2025 Oct; 17 (5): 2942–2952. https://doi.org/10.1007/s12602-024-10238-y

76. Тарасова Л. В., Трухан Д. И. Болезни кишечника. Клиника, диагностика и лечение. Санкт-Петербург: СпецЛит, 2022. 222 с. URL: https://www.elibrary.ru/item.asp?id=49497776

77. Трухан Д. И., Филимонов С. Н. Заболевания кишечника в терапевтической практике. Клиника, диагностика и принципы лечения: учебное пособие. Новокузнецк: ИП Петровский К. В. (Изограф), 2025. 296 с. URL: https://elibrary.ru/item.asp?id=82802758

78. Han R, Gao C, Yan P, Tian Y, Yu Y, Li H, Li S, Wang Y. Effect of intervention with Bifidobacterium animalis subsp. lactis BLa80 on the composition of the gut microbiota of healthy volunteers: a placebo-controlled randomized trial. J Clin Biochem Nutr. 2025 Nov 1; 77 (3): 288–295. https://doi.org/10.3164/jcbn.25-99

79. Chen K, Jin S, Ma Y, Cai L, Xu P, Nie Y, Luo L, Yu Q, Shen Y, Zhou Z, Liu C. Adjudicative efficacy of Bifidobacterium animalis subsp. lactis BLa80 in treating acute diarrhea in children: a randomized, double-blinded, placebo-controlled study. Eur J Clin Nutr. 2024 Jun; 78 (6): 501–508. https://doi.org/10.1038/s41430-024-01428-6

80. Salo E, Roche D, Gomez-Martinez VB, Cruz-Domenech JM, Garcia-Mora LG, Gabernet-Castello C, Freixenet N. Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study.Benef Microbes. 2024 Sep 5; 15 (6): 679–688. https://doi.org/10.1163/18762891-bja00038

81. Liu Y, Chen Y, Zhang Q, Zhang Y, Xu F. A double blinded randomized placebo trial of Bifidobacterium animalis subsp. lactis BLa80 on sleep quality and gut microbiota in healthy adults. Sci Rep. 2025 Apr 1; 15 (1): 11095. https://doi.org/10.1038/s41598-025-95208-2

82. Zhao C, Lu X, Deng X, Xia W, Sun T, Huo D, Shi L. The effects of Bifidobacterium animalis subsp. lactis BLa80 on glycemic control and gut microbiota in patients with T2DM: a randomized, double-blind, placebo-controlled trial. J Diabetes Complications. 2025 Dec; 39 (12): 109195. https://doi.org/10.1016/j.jdiacomp.2025.109195

83. Zhang Z, Li J, Wan Z, Fang S, Zhao Y, Li Q, Zhang M. Bifidobacterium animalis subsp. lactis BLa80 alleviates constipation in mice through modulating the stem cell factor (SCF)/c-Kit pathway and the gut microbiota. Food Funct. 2025 Mar 17; 16 (6): 2347–2362. https://doi.org/10.1039/d4fo06350c

84. Dong Y, Liao W, Tang J, Fei T, Gai Z, Han M. Bifidobacterium BLa80 mitigates colitis by altering gut microbiota and alleviating inflammation. AMB Express. 2022 Jun 7; 12 (1): 67. https://doi.org/10.1186/s13568-022-01411-z

85. Gu J, Song K, Fan Y, Dong Y, Qian L, Gai Z. Safety evaluation of Bifidobacterium animalis subsp. lactis BLa80 under in vitro, and in vivo conditions. Microb Pathog. 2024 Sep; 194: 106809. https://doi.org/10.1016/j.micpath.2024.106809

86. Niu Q, Wang W, Liang Y, Fang S, Wan L, Yang G. Efficacy and Safety of a Probiotic Mixture Containing Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 in Children With Attention-Deficit/Hyperactivity Disorder. Mol Nutr Food Res. 2025 Nov; 69 (22): e70234. https://doi.org/10.1002/mnfr.70234

87. Liu Y, Wang J, Gao Y, Wang Z, Zhu C, Xu F, Chen Y. Impact of Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota and metabolic health of alcohol-consuming individuals: a randomised, double-blind, placebo-controlled trial.Benef Microbes. 2025 Jun 16; 17 (1): 11–27. https://doi.org/10.1163/18762891-bja00083

88. Feng J, Wu J, Zhang M, Chen W, Zhao J, Lv Y, Lai R, Fang S, Li Y. Multi-Strain Probiotics Alleviate Alcoholic Liver Disease Via Microbiota-Metabolism Axis: A Randomized Controlled Study.Probiotics Antimicrob Proteins. 2025 Nov 3. https://doi.org/10.1007/s12602-025-10818-6. Online ahead of print.

89. An PP, Liang XY, Yao XY, Liao ZH, Tang YC, Cao N, Wang Z, Wang W, Niu HY, Tang CX, Chen J. Bifidobacterium breve BBr60 Enhances SCFA Levels and Restores NLRP3/NLRP6 Balance in the Gut to Improve Motor Deficits in PD Mice. Probiotics Antimicrob Proteins. 2025 Jun 6. https://doi.org/10.1007/s12602-025-10576-5. Online ahead of print.

90. Bai Z, Wu Y, Gao D, Dong Y, Pan Y, Gu S. Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial. Int J Mol Sci. 2024 Oct 10; 25 (20): 10871. https://doi.org/10.3390/ijms252010871

91. Gao D, Dong Y, Jia Z, Bian C, Zhu J, Wu Y, Fang S, Gu S. Bifidobacterium Breve BBr60 Improves Obesity Via the Gut Microbiota-Short-Chain Fatty Acid-IL-27/GLP-1 Axis: Evidence from a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2025 Dec 27. https://doi.org/10.1007/s12602-025-10885-9. Online ahead of print.

92. Dong Y, Cai Y, Tian H, Wen J, Han M, Tan Y, Zou K. The impact of Bifidobacterium breve BBr60 (BBr60) on metabolic and gastrointestinal health in healthy adults: A combined in vitro metabolomic and randomized, double-blind, placebo-controlled study. Clin Nutr. 2025 Aug; 51: 349–361. https://doi.org/10.1016/j.clnu.2025.07.004

93. Wu Y, Gao D, Pan Y, Dong Y, Bai Z, Gu S. Modulation of Serum Metabolic Profiles by Bifidobacterium breve BBr60 in Obesity: A Randomized Controlled Trial. Foods. 2024 Nov 17; 13 (22): 3655. https://doi.org/10.3390/foods13223655

94. Costa LCMC, Carvalho MDG, Vale FF, Marques AT, Rasmussen LT, Chen T, Barros-Pinheiro M. Helicobacter pylori in oral cavity: current knowledge. Clin Exp Med. 2024 Sep 4; 24 (1): 209. https://doi.org/10.1007/s10238-024-01474-1

95. Ren Q, Yan X, Zhou Y, Li WX. Periodontal therapy as adjunctive treatment for gastric Helicobacter pylori infection. Cochrane Database Syst Rev. 2016 Feb 7; 2 (2): CD 009477. https://doi.org/10.1002/14651858.CD009477.pub2

96. Трухан Д. И., Сулимов А. Ф., Трухан Л. Ю. Коморбидность патологии пародонта и язвенной болезни. Клинический разбор в общей медицине. 2024; 5 (10): 6–11. https://doi.org/10.47407/kr2024.5.10.00488

97. Liu Q, Zhang Y, Qi F. Association Between Helicobacter Pylori Infection and Periodontal and Gastric Diseases: A Meta-Analysis. Int Dent J. 2025 Jun; 75 (3): 1510–1521. https://doi.org/10.1016/j.identj.2024.12.027

98. Fernández CE, Maturana-Valenzuela C, Rojas-Castillo N, Rosier B. Potential effects of prebiotic fibers on dental caries: a systematic review.J Sci Food Agric. 2025 Aug 30; 105 (11): 5640–5651. https://doi.org/10.1002/jsfa.14113

99. Kleessen B., Sykura B., Zunft H. J., Blaut M. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr. 1997; 65 (5): 1397–1402. https://doi.org/10.1093/ajcn/65.5.1397

100. Kleessen B, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M. Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers.Br J Nutr. 2007 Sep; 98 (3): 540–9. https://doi.org/10.1017/S0007114507730751

101. Mensink M. A., Frijlink H. W., van der Voort Maarschalk K., Hinrichs W. L. Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications. Carbohydr Polym. 2015; 134: 418–428. https://doi.org/10.1016/j.carbpol.2015.08.022

102. Ji Z, Mei J, Li Y, Wang Z, Guo Z, Miao L. Association between oral health and bowel habits: a cross-sectional study. BMC Public Health. 2025 Apr 21; 25 (1): 1462. https://doi.org/10.1186/s12889-025-22747-8

103. Niness KR. Inulin and oligofructose: what are they? J Nutr. 1999 Jul; 129 (7 Suppl): 1402S-6S. https://doi.org/10.1093/jn/129.7.1402S

104. Tandon D, Haque MM, Gote M, Jain M, Bhaduri A, Dubey AK, Mande SS. A prospective randomized, double-blind, placebo-controlled, dose-response relationship study to investigate efficacy of fructo-oligosaccharides (FOS) on human gut microflora. Sci Rep. 2019 Apr 2; 9 (1): 5473. https://doi.org/10.1038/s41598-019-41837-3

105. Wang Q, Li J, Tu Y, Cai J, Ren F, Zhang H. Characteristics and antioxidant activity of Maillard reaction products from β-lactoglobulin and isomaltooligosaccharide. Front Nutr. 2023 Oct 17; 10: 1282485. https://doi.org/10.3389/fnut.2023.1282485

106. Nawrot-Hadzik I, Matkowski A, Kubasiewicz-Ross P, Hadzik J. Proanthocyanidins and Flavan-3-ols in the Prevention and Treatment of Periodontitis-Immunomodulatory Effects, Animal and Clinical Studies. Nutrients. 2021 Jan 15; 13 (1): 239. https://doi.org/10.3390/nu13010239

107. Febvey A, Silva F, Henriques B, Özcan M, Teughels W, Souza JCM. Root canal disinfection and maintenance of the remnant tooth tissues by using grape seed and cranberry extracts. Odontology. 2023 Jul; 111 (3): 541–553. https://doi.org/10.1007/s10266-022-00766-w

108. Basu A, Masek E, Ebersole JL. Dietary Polyphenols and Periodontitis-A Mini-Review of Literature. Molecules. 2018 Jul 20; 23 (7): 1786. https://doi.org/10.3390/molecules23071786

109. Bodet C, Chandad F, Grenier D. Cranberry components inhibit interleukin‑6, interleukin-8, and prostaglandin E production by lipopolysaccharide-activated gingival fibroblasts. Eur J Oral Sci. 2007 Feb; 115 (1): 64–70. https://doi.org/10.1111/j.1600-0722.2007.00415.x

110. Bonifait L, Grenier D. Cranberry polyphenols: potential benefits for dental caries and periodontal disease. J Can Dent Assoc. 2010; 76: a130. URL: https://pubmed.ncbi.nlm.nih.gov/20943032/

111. Sánchez MC, Ribeiro-Vidal H, Bartolomé B, Figuero E, Moreno-Arribas MV, Sanz M, Herrera D. New Evidences of Antibacterial Effects of Cranberry Against Periodontal Pathogens. Foods. 2020 Feb 24; 9 (2): 246. https://doi.org/10.3390/foods9020246

112. de Medeiros AKB, de Melo LA, Alves RAH, Barbosa GAS, de Lima KC, Porto Carreiro ADF. Inhibitory effect of cranberry extract on periodontopathogenic biofilm: An integrative review. J Indian Soc Periodontol. 2016 Sep-Oct; 20 (5): 503–508. https://doi.org/10.4103/jisp.jisp_302_16

113. Vaillancourt K, Ben Lagha A, Grenier D. Effects of a Berry Polyphenolic Fraction on the Pathogenic Properties of Porphyromonas gingivalis. Front Oral Health. 2022 Jun 16; 3: 923663. https://doi.org/10.3389/froh.2022.923663

114. Grenier D, La VD. Proteases of Porphyromonas gingivalis as important virulence factors in periodontal disease and potential targets for plant-derived compounds: a review article. Curr Drug Targets. 2011 Mar 1; 12 (3): 322–31. https://doi.org/10.2174/138945011794815310

115. Olsen I, Potempa J. Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases. J Oral Microbiol. 2014 Aug 18; 6. https://doi.org/10.3402/jom.v6.24800

116. Manso IS, Bauer YG, Magini EB, Magrin GL, da Silva IT, Cruz ACC. Exploring the Benefits of Cranberries in Dentistry: A Comprehensive Review.Biomedicines. 2025 Dec 31; 14 (1): 85. https://doi.org/10.3390/biomedicines14010085

117. Farhad SZ, Karbalaeihasanesfahani A, Dadgar E, Nasiri K, Hosseini NM, Valian N, Esfahaniani M, Nabi Afjadi M. Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review. Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb; 398 (2): 1367–1389. https://doi.org/10.1007/s00210-024-03457-1

118. Sezgin Y, Bilgin Çetin M, Terzi YK, Darcansoy İşeri Ö, Erinanç H, Şahin Fİ, Bakırarar B, Özerkliğ İ, Bulut Ş, Alptekin NÖ. Effect of resveratrol on the antioxidant enzyme pathway and alveolar bone loss in experimental periodontitis. Acta Odontol Scand. 2025 Dec 15; 84: 607–615. https://doi.org/10.2340/aos.v84.44956

119. Vaisman N, Niv E. Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study. Int J Food Sci Nutr. 2015 May; 66 (3): 342–9. https://doi.org/10.3109/09637486.2014.1000840

120. Трухан Д. И., Сулимов А. Ф., Трухан Л. Ю. Возможности витаминно-минеральных комплексов в адъювантной терапии коморбидных пациентов с заболеваниями пародонта, сахарным диабетом и другими системными заболеваниями организма. Клинический разбор в общей медицине. 2024; 5 (5): 91–100. https://doi.org/10.47407/kr2024.5.5.00411

121. Livingstone C. Zinc: physiology, deficiency, and parenteral nutrition. Nutr Clin Pract. 2015 Jun; 30 (3): 371–82. https://doi.org/10.1177/0884533615570376

122. Poleník P. Zinc in etiology of periodontal disease. Med Hypotheses. 1993 Mar; 40 (3): 182–5. https://doi.org/10.1016/0306-9877 (93) 90208-8

123. Caruso S, Valenti C, Marinucci L, Di Pasquale F, Truppa C, Di Benedetto G, Caruso S, Pagano S. Systematic Review of Zinc's Benefits and Biological Effects on Oral Health. Materials (Basel). 2024 Feb 7; 17 (4): 800. https://doi.org/10.3390/ma17040800