IPL-therapy in skin geroprotection: current clinical challenges, combined strategies and therapeutic perspectives

Skin aging is a multi-level pathological process characterized by heterogeneity and a close interconnection of molecular and cellular disturbances. These include loss of proteostasis and epigenetic alterations, activation of specific pro-inflammatory cascades, mitochondrial dysfunction, and persistent disruption of intercellular communication, among others. The accumulation of such damages poses a significant methodological challenge for contemporary local geroprotection, necessitating a move beyond mono-therapeutic approaches. This review analyzes the pathogenetic foundations for developing combined strategies. The primary focus is on the synergistic potential of combining Intense Pulsed Light (IPL) with injectable cosmetology methods. Within this framework, the potential for targeted delivery of vitamins, peptides, amino acids, and trace elements in the form of mechano-chemical conjugates is evaluated for correcting deep metabolic deficits associated with aging. Based on a systematization of current data, a conceptual model is formulated that substantiates the need for personalized combined protocols. It is proposed that such a multimodal strategy, sequentially targeting various pathogenetic links – from neutralizing exogenous aggressors and mitigating chronic inflammation to directly restoring the extracellular matrix and cellular homeostasis – can not only effectively correct the visual manifestations of aging but also influence fundamental biological processes. Thus, a rational combination of IPL therapy and modern bioreparants is considered a promising avenue for achieving sustainable clinical results in correcting both chronological and photo-induced skin aging.

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