The relationship between monoamine oxidase deficiency and inheritance of aggressive behavior
https://doi.org/10.33667/2078-5631-2026-4-46-4
Abstract
Impulsive aggression is a widespread behavior problem. The article presents the results of studying the relationship of pathologically aggressive behavior with hereditary factors. The tendency to aggressive behavior is interrelated with serotonin metabolism, which is regulated by the monoamine oxidase (MAO) gene. The research results indicate that aggressive behavior is correlated with the number of tandem repeats of the monoamine oxidase А (MAOA) gene. Reactive aggression is promoted by low-functional variants of alleles. The tendency to aggression is influenced by the presence of abuse, neglect, or traumatic life events in childhood. Alleles of the MAOA gene are associated not only with impulsive aggression in an individual, but also with the influence of the environment on the formation of aggressive criminal behavior. Examples are given when a genetic predisposition to criminal behavior served as an argument in favor of a reduced sentence. Behavioral genetics research requires more serious requirements for research design and methodology in order to obtain reliable and reliable results.
About the Authors
N. V. Orlova
N.I. Pirogov Russian National Research Medical University (Pirogov University);
Tyumen State University
Russian Federation
Russian Federation
Orlova Natalia V., Dr Med Sci (habil.), professor at Dept of Faculty Therapy of Institute of Motherhood and Childhood, N.I. Pirogov Russian National Research Medical University (Pirogov University), leading researcher at the laboratory, Tyumen State University
Moscow, Tyumen
G. N. Suvorov
Tyumen State University
Russian Federation
Russian Federation
Suvorov Georgy N., PhD in Law, head of Dept of Scientific and Innovative Work, head of the laboratory
Tyumen
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Review
For citations:
Orlova N.V., Suvorov G.N. The relationship between monoamine oxidase deficiency and inheritance of aggressive behavior. Medical alphabet. 2026;(4):46-49. (In Russ.) https://doi.org/10.33667/2078-5631-2026-4-46-4
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