medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2026-4-46-4medalphabet-4900Research ArticleСтатьиВзаимосвязь дефицита моноаминоксидазы и наследования агрессивного поведенияThe relationship between monoamine oxidase deficiency and inheritance of aggressive behaviorhttps://orcid.org/0000-0002-4293-3285ОрловаН. В.OrlovaN. V.

Орлова Наталья Васильевна, д. м. н., проф., проф. кафедры факультетской терапии Института материнства и детства, ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России (Пироговский университе, ведущий научный сотрудник лаборатории, ФГАОУ ВО «Тюменский государственный университет»

Москва, Тюмень

Orlova Natalia V., Dr Med Sci (habil.), professor at Dept of Faculty Therapy of Institute of Motherhood and Childhood, N.I. Pirogov Russian National Research Medical University (Pirogov University), leading researcher at the laboratory, Tyumen State University

Moscow, Tyumen

vrach315@yandex.ruhttps://orcid.org/0000-0001-8452-5522СуворовГ. Н.SuvorovG. N.

Суворов Георгий Николаевич, к. ю. н., начальник управления научной и инновационной работы, заведующий лабораторией

Тюмень

Suvorov Georgy N., PhD in Law, head of Dept of Scientific and Innovative Work, head of the laboratory

Tyumen

ipk6019086@yandex.ruФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России (Пироговский университет); ФГАОУ ВО «Тюменский государственный университет»РоссияN.I. Pirogov Russian National Research Medical University (Pirogov University); Tyumen State UniversityRussian FederationФГАОУ ВО «Тюменский государственный университет»РоссияTyumen State UniversityRussian Federation20262003202604Современная поликлиника (1)4649Copyright © Орлова Н.В., Суворов Г.Н., 20262026Орлова Н.В., Суворов Г.Н.Orlova N.V., Suvorov G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4900

Импульсивная агрессия широко распространенная проблема поведения. В статье представлены результаты изучения взаимосвязи патологического агрессивного поведения с наследственными факторами. Склонность к агрессивному поведению взаимосвязана с обменом серотонина, в регуляции которого задействован ген моноаминоксидазы (МАО). Результаты исследований свидетельствуют, что агрессивное поведение взаимосвязано с количеством тандемных повторов гена моноаминоксидазы А (MAOA). Реактивной агрессии способствуют низкофункциональные варианты аллелей. На склонность к агрессии влияет наличие жестокого обращения, пренебрежения или травмирующих жизненных событий в детском возрасте. Аллели гена МАОА связаны не только с импульсивной агрессией у индивида, но и с влиянием окружающей среды на формирование агрессивного преступного поведения. Приведены примеры, когда генетическая предрасположенность к преступному поведению послужила аргументом в пользу смягчения приговора. Исследования поведенческой генетики требуют более серьезных требований к дизайну и методологии исследований для получения достоверности и надежности результатов.

Impulsive aggression is a widespread behavior problem. The article presents the results of studying the relationship of pathologically aggressive behavior with hereditary factors. The tendency to aggressive behavior is interrelated with serotonin metabolism, which is regulated by the monoamine oxidase (MAO) gene. The research results indicate that aggressive behavior is correlated with the number of tandem repeats of the monoamine oxidase А (MAOA) gene. Reactive aggression is promoted by low-functional variants of alleles. The tendency to aggression is influenced by the presence of abuse, neglect, or traumatic life events in childhood. Alleles of the MAOA gene are associated not only with impulsive aggression in an individual, but also with the influence of the environment on the formation of aggressive criminal behavior. Examples are given when a genetic predisposition to criminal behavior served as an argument in favor of a reduced sentence. Behavioral genetics research requires more serious requirements for research design and methodology in order to obtain reliable and reliable results.

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The authors declare that there are no conflicts of interest present.