Management of patients with hypertrophic scars using capacitive‑resistive electrotherapy at 448 kHz (literature review)
https://doi.org/10.33667/2078-5631-2025-23-25-28
Abstract
Hypertrophic scars represent a common clinical complication arising from impaired wound healing and tissue regeneration processes, leading to significant aesthetic, functional, and psychological consequences that markedly reduce patients’ quality of life. This review evaluates the clinical significance and therapeutic efficacy of capacitive resistive electric transfer (CRET) therapy at 448 kHz for managing pathological scar formation. The findings demonstrate that CRET therapy effectively modulates inflammatory responses, regulates collagen synthesis, promotes tissue remodeling, and enhances skin elasticity. This non invasive therapeutic modality shows substantial clinical potential as a device based treatment approach that significantly improves patient outcomes by reducing fibrotic manifestations and optimizing wound healing processes.
About the Authors
L. A. RubtsovaRussian Federation
Rubtsova Lyubov A., dermatovenerologist
Moscow
L. S. Kruglova
Russian Federation
Kruglova Larisa S., DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, vice‑rector for Academic Affairs
Moscow
M. S. Kruglova
Russian Federation
Kruglova Maria S., 5th year student at Faculty of Medicine
Moscow
A. V. Sychev
Russian Federation
Sychev Andrey V., PhD Med, associate professor at Dept of Surgery with a Course in Endoscopy, vice-rector for Academic Affairs, academic secretary of Academic Council
Moscow
References
1. Manturova N.E., Kruglova L.S., Stenko A.G. Skin scars. Clinical manifestations, diagnosis and treatment. M.: GEOTAR Media, 2021. (In Russ.).
2. Hernández Bule M. L. et al. Anti fibrotic effects of RF electric currents // International Journal of Molecular Sciences.– 2023.– V. 24.– № . 13.– P. 10986. DOI: 10.3390/ijms241310986. PMID: 37446165; PMCID: PMC10341950.
3. Rubtsova L.A., Kruglova L.S., Kruglova M.S. Modern concepts of post burn cicatricial lesions. Effective pharmacotherapy. 2023; 19 (39): 22–26. (In Russ.).
4. Park Y.R. et al. NF κB signaling is key in the wound healing processes of silk fibroin //Acta biomaterialia. 2018; (67): 183–195. DOI: 10.1016/j.actbio.2017.12.006
5. Nischwitz S.P. et al. The role of local inflammation and hypoxia in the formation of hypertrophic scars – a new model in the duroc pig // International Journal of Molecular Sciences. 2022; 24 (1): 316. DOI: 10.3390/ijms24010316. PMID: 36613761; PMCID: PMC9820621
6. Lingzhi Z., Meirong L., Xiaobing F. Biological approaches for hypertrophic scars // International wound journal. 2020; 17 (2): 405–418. DOI: 10.1111/iwj.13286
7. Jiang D., Rinkevich Y. Scars or regeneration? – Dermal fibroblasts as drivers of diverse skin wound responses // International journal of molecular sciences. 2020; 21 (2): 617. DOI: 10.3390/ijms21020617
8. Rubtsova L.A. et al. Modern methods of managing pediatric patients with post burn cicatricial lesions: clinical observations // Issues of modern pediatrics. 2024; 23 (5): 329–335. (In Russ.).
9. Ekelem C. et al. Radiofrequency therapy and noncosmetic cutaneous conditions // Dermatologic Surgery. 2019.; 45 (7): 908–930. DOI: 10.1097/DSS.0000000000001925. PMID: 30893163; PMCID: PMC10939175
10. Pinheiro N.M. et al. Effects of radiofrequency procedure on hypertrophic scar due to burns // Journal of the European Academy of Dermatology & Venereology. 2015; 29 (1). DOI: 10.1111/jdv.12388. Epub 2014 Feb 14. PMID: 24673645
11. Hernández Bule M. L. et al. In vitro stimulation with radiofrequency currents promotes proliferation and migration in human keratinocytes and fibroblasts // Electromagnetic Biology and Medicine. 2021; 40 (3): 338–352.https://doi.org/10.1080/15368378.2021.1938113
12. Khedr M.M. et al. Comparison of Nd: YAG laser and combined intense pulsed light and radiofrequency in the treatment of hypertrophic scars: A prospective clinico histopathological study // Annals of Plastic Surgery. 2020; 84 (5): 518–524. DOI: 10.1097/SAP.0000000000002086
13. Trelles M.A., Martínez Carpio P.A. Clinical and histological results in the treatment of atrophic and hypertrophic scars using a combined method of radiofrequency, ultrasound, and transepidermal drug delivery //International journal of dermatology. 2016; 55 (8): 926–933. DOI: 10.1111/ijd.13253
14. Nicoletti G. et al. Scar remodeling with the association of monopolar capacitive radiofrequency, electric stimulation, and negative pressure //Photomedicine and Laser Surgery. 2017; 35 (5): 246–258. DOI: 10.1089/pho.2016.4180
15. Hernández Bule M. L. et al. Effects of RF currents on cytokines production in human keratinocytes // Medical Sciences Forum. MDPI, 2023; 21. (1): 29. https://doi.org/10.3390/ECB2023–14096
Review
For citations:
Rubtsova L.A., Kruglova L.S., Kruglova M.S., Sychev A.V. Management of patients with hypertrophic scars using capacitive‑resistive electrotherapy at 448 kHz (literature review). Medical alphabet. 2025;1(23):25-28. (In Russ.) https://doi.org/10.33667/2078-5631-2025-23-25-28
























