Personalized correction of micronutrient status in gestational diabetes mellitus: from screening to therapy
https://doi.org/10.33667/2078-5631-2025-22-74-78
Abstract
Relevance. Low levels of vitamin D, folic acid and inositol in pregnant women are associated with a history of both obstetric and perinatal complications, as well as extragenital diseases. Recently, an increasing number of studies have been focused on identifying cause-and-effect relationships between impaired micronutrient status during gestation and signs of gestational diabetes mellitus.
Objective. To review literature from the past 7 years in international (PubMed) and eLIBRARY.RU to study the micronutrient status in women with a history of gestational diabetes mellitus and to evaluate the impact of this condition on pregnancy.
Materials and Methods. Scientific databases PubMed and eLIBRARY.RU were analyzed for the period 2018–2025. A total of 107 publications were identified, of which 36 were selected for analysis.
Results. The obtained data indicate that supplementation with vitamin D and inositol in women with gestational diabetes mellitus correlated with a more favorable course of pregnancy and successful delivery. The study of folic acid’s impact on patients with this condition yielded directly opposite results.
Conclusion. Therefore, there is a need to implement systematic monitoring of micronutrient status in the pregravid period and throughout pregnancy to ensure timely correction of identified deficiency states.
About the Authors
S. V. Khabarov
Medma Medical Group, Genom Reproductive Health Clinic Network, VITROMED LLC, VitroClinic Clinic; Academy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency of Russia; Tula State University, Medical Institute
Russian Federation
Russian Federation
Khabarov Sergey V., chief physician; DM Sci (habil.), professor at Dept of Clinical Laboratory Diagnostics, Medical Microbiology and Pathological Anatomy; professor at Dept of Obstetrics and Gynecology
Moscow
Tula
K. O. Nechay
Academy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nechay Ksenia O., postgraduate student at Dept of Clinical Laboratory Diagnostics, Medical Microbiology and Pathological Anatomy
Moscow
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For citations:
Khabarov S.V., Nechay K.O. Personalized correction of micronutrient status in gestational diabetes mellitus: from screening to therapy. Medical alphabet. 2025;(22):74-78. (In Russ.) https://doi.org/10.33667/2078-5631-2025-22-74-78
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