Reliability of using the method of immunochromatographic analysis to determine benzodiazepine receptor agonists in the diagnosis of acute poisoning
https://doi.org/10.33667/2078-5631-2025-22-59-62
Abstract
The immunochromatographic method (ICA) is widely used as a representative and screening study for forensic chemical and chemical-toxicological analysis. The method used has advantages and disadvantages. The disadvantages include both false positive and false negative results. A study was conducted on the detection of benzodiazepine receptor agonists of different chemical structures by the IHA method, the results of which have significant negative results on zaleplon and zopiclone. When tested for clobazam, the result is positive for benzodiazepines, and for phenazepam, it gives a false negative result when detected for a group of benzodiazepines.
About the Authors
A. A. Vоlkova
Russian Center for Forensic Medical Examination; Peoples’ Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Vоlkova Alla A., PhD Pharm, leading researcher
Moscow
R. A. Kаlekin
Russian Center for Forensic Medical Examination; Peoples’ Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Kаlekin Roman A., Dr Pharm Sci (habil.), chief researcher
Moscow
A. M. Orlova
Russian Center for Forensic Medical Examination
Russian Federation
Russian Federation
Orlova Alevtina M., PhD Pharm, leading researcher
Moscow
S. S. Barseghyan
Russian Center for Forensic Medical Examination
Russian Federation
Russian Federation
Barseghyan Samvel S., PhD Pharm, head of Dept of Forensic Chemical and Chemical-Toxicological Examination
Moscow
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Review
For citations:
Vоlkova A.A., Kаlekin R.A., Orlova A.M., Barseghyan S.S. Reliability of using the method of immunochromatographic analysis to determine benzodiazepine receptor agonists in the diagnosis of acute poisoning. Medical alphabet. 2025;(22):59-62. (In Russ.) https://doi.org/10.33667/2078-5631-2025-22-59-62
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