Diagnostic algorithms of periprosthetic joint infection. The role of laboratory biomarkers (literature review)
https://doi.org/10.33667/2078-5631-2025-22-37-42
Abstract
Hip and knee arthroplasty is currently considered as the surgery of the century. In terms of pain relief, correction of deformations and restoration of lost functions, the operation is second to none. Moreover, no surgical intervention has had such profound social consequences. The technique is really beneficial to patients because of early recovery. On the one hand, the number of primary arthroplastic surgeries, on the other hand, the number of revision surgeries is increasing as well. Significant number of revision surgeries is associated with periprosthetic joint infection. The latent course of the prosthetic joint infection is often mistaken for aseptic loosening, which significantly affects the tactics of surgical treatment and its outcomes, and increases the number of repeated revision interventions. New diagnostic algorithms have been developed over the years. Since none of the diagnostic tests has 100 % sensitivity and specificity, it is necessary to use a combination of various diagnostic procedures, including clinical, radiological, cytological, histological as well as microbiological tests. Proper diagnosis contributes to optimization of treatment tactics and results in favorable outcome. Thus, that is why the search for the “golden” test continues.
About the Authors
S. A. Guzyukina
Federal Center of Traumatology, Orthopedics and Endoprosthetics
Russian Federation
Russian Federation
Guzyukina Svetlana A., physician of clinical laboratory diagnostics, head of Clinical Diagnostic Laboratory
Smolensk
A. P. Roytman
Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Roytman Alexander P., DM Sci (habil.), professor at Dept of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology
Moscow
M. G. Lambakakhar
Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Lambakahar Maria G., PhD Med, associate professor at Dept of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology
Moscow
A. V. Ovsyankin
Federal Center of Traumatology, Orthopedics and Endoprosthetics
Russian Federation
Russian Federation
Ovsyankin Anatoly V., PhD Med, associate professor, chief physician
Smolensk
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For citations:
Guzyukina S.A., Roytman A.P., Lambakakhar M.G., Ovsyankin A.V. Diagnostic algorithms of periprosthetic joint infection. The role of laboratory biomarkers (literature review). Medical alphabet. 2025;(22):37-42. (In Russ.) https://doi.org/10.33667/2078-5631-2025-22-37-42
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