Preview

Medical alphabet

Advanced search
Open Access Open Access  Restricted Access Subscription or Fee Access

The effectiveness of injectable exoprotectors for recovering facial skin quality. Literature review and clinical observations

https://doi.org/10.33667/2078-5631-2025-8-100-105

Abstract

Objective. To analyze the therapeutic efficacy of the combined use of NOVACUTAN YBio and SBio drugs for the correction of a wide range of dermatological disorders. Based on the data obtained, we recommend the inclusion of these products in post-procedural rehabilitation after aggressive cosmetic procedures (laser resurfacing, chemical peels), as well as for dyschromia, signs of photoaging, decreased skin tone and turgor, dull uneven complexion, dehydration and peeling of the epidermis, and skin microrelief disorders.

Materials and methods. Clinical experience in the use of NOVACUTAN YBio/SBio and NOVACUTAN BTA exoprotectors according to the «Beaty flash» and «High-light» protocols.

Results. Injectable exoprotectors are effective as a therapeutic agent for repairing photo-damaged skin, as well as for protecting it from exposure to light, including UVA and UVB rays.

Conclusion. Based on the results obtained, we recommend using exoprotectors during the recovery period after aggressive cosmetic procedures, as well as as a therapeutic agent against photoaging of the facial skin.

About the Authors

Z.  I. Gazitaeva
MedBioSystem LLC
Russian Federation

Gazitaeva Zarema I., PhD Med, maxillofacial surgeon, plastic surgeon, geriatric, director of Medical Department Novacutan

Moscow



O. V. Zabnenkova
Olymp Clinic
Russian Federation

Zabnenkova Olga V., PhD Med, cosmetologist, dermatovenerologist. head of Cosmetology Dept, deputy chief Cosmetology Physician

Moscow



References

1. Arora G., Arora S., Sadoughifar R., Batra N. Biorevitalization of the skin with skin boosters: Concepts, variables, and limitations. Journal of cosmetic dermatology. 2021; 20 (8): 2458–2462. https://doi.org/10.1111/jocd.13871

2. Iorizzo M., De Padova M.P., Tosti A. Biorejuvenation: theory and practice. Clinics in dermatology. 2008; 26 (2): 177–181. https://doi.org/10.1016/j.clindermatol.2007.09.011

3. Robin S., Fanian F., Courderot-Masuyer C., Tordjman M. et al. Efficacy of a Biorevitalizing-Filler Solution on All Skin Aspects: 10 Years Approach through in Vitro Studies and Clinical Trials. Journal of Cosmetics, Dermatological Sciences and Applications. 2021; 11: 18–37. DOI: 10.4236/jcdsa.2021.111003

4. Jäger C. et al. Bioactive reagents used in mesotherapy for skin rejuvenation in vivo induce diverse physiological processes in human skin fibroblasts in vitro–a pilot study. Experimental dermatology. 2012; 21 (1): 72–75.

5. Byun K.A., Oh S., Batsukh S. et al. The Extracellular Matrix Vitalizer RATM Increased Skin Elasticity by Modulating Mitochondrial Function in Aged Animal Skin. Antioxidants (Basel, Switzerland). 2023; 12 (3): 694. https://doi.org/10.3390/antiox12030694

6. Prikhnenko S. Polycomponent mesotherapy formulations for the treatment of skin aging and improvement of skin quality. Clinical, cosmetic and investigational dermatology. 2015; 8: 151–157. https://doi.org/10.2147/CCID.S76721

7. Moy R. Injections in Aesthetic Medicine: Atlas of Full-face and Full-body Treatment. Aesthetic Surgery Journal. 2015; 35 (4): NP98–NP99. DOI: 10.1093/asj/sju002

8. Dioguardi F. S. Nutrition and skin. Collagen integrity: a dominant role for amino acids. Clinics in Dermatology. 2008; 26 (6): 636–640. https://doi.org/10.1016/j.clindermatol.2007.09.004

9. Scarano A., Sbarbati A., Amore R. et al. The role of hyaluronic acid and amino acid against the aging of the human skin: A clinical and histological study. Journal of cosmetic dermatology. 2021; 20 (7): 2296–2304. https://doi.org/10.1111/jocd.13811

10. Sparavigna A., Orlandini A. Efficacy and Tolerance of an Injectable Medical Device Containing Hyaluronic Acid and Amino acids: A Monocentric Six-Month Open-Label Evaluation. J Clin Trials. 2017; 7: 4. https://doi.org/10.4172/2167–0870.1000316

11. Wang F., Ma W., Fan D. et al. The biochemistry of melanogenesis: an insight into the function and mechanism of melanogenesis-related proteins. Front. Mol. Biosci. 2024; 11. https://doi.org/10.3389/fmolb.2024.1440187

12. Lorenzo R., Bernardi A., Grumetto L. et al. Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential. Molecules. 2021; 26 (21): 6611. https://doi:10.3390/molecules26216611

13. Voegeli R., Rawlings A., Seroul P. et al. A novel continuous colour mapping approach for visualization of facial skin hydration and transepidermal water loss for four ethnic groups. Int J Cosmet Sci. 2015; 37 (6): 595–605. DOI: 10.1111/ics.12265

14. Sonthalia S, Daulatabad D, Sarkar R. Glutathione as a skin whitening agent: Facts, myths, evidence and controversies. Indian J Dermatol Venereol Leprol. 2016; 82 (3): 262–272. DOI: 10.4103/0378–6323.179088

15. Prikhnenko S. Polycomponent mesotherapy formulations for the treatment of skin aging and improvement of skin quality. Clin Cosmet Investig Dermatol. 2015; 8: 151–157. Published 2015 Apr 7. doi:10.2147/CCID.S76721

16. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004; 134 (3): 489–492. DOI: 10.1093/jn/134.3.489

17. Shoulders MD, Raines RT. Collagen structure and stability. Annu Rev Biochem. 2009; 78: 929–958. DOI: 10.1146/annurev.biochem.77.032207.120833

18. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012; 4 (3): 253–258. DOI: 10.4161/derm.21923

19. Stechmiller J., Childress B., Cowan L. Arginine supplementation and wound healing. Nutr Clin Pract. 2005; 20 (1): 52–61. DOI: 10.1177/011542650502000152

20. Kohen R. Skin antioxidants: their role in aging and in oxidative stress – new approaches for their evaluation. Biomed Pharmacother. 1999; 53 (4): 181–192. DOI: 10.1016/S0753–3322(99)80087 0

21. Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014; 27 (1): 47–55. doi:10.1159/000351376

22. Stechmiller JK, Childress B, Cowan L. Arginine supplementation and wound healing. Nutr Clin Pract. 2005; 20 (1): 52–61. DOI: 10.1177/011542650502000152

23. Luo J., Chen A. Nitric oxide: a newly discovered function on wound healing. Acta Pharmacol Sin. 2005; 26 (3): 259–264. DOI: 10.1111/j.1745–7254.2005.00058.x

24. Norqulova X. Mesotherapy in cosmetology. Modern Science and Research. 2024; 8 (2): 137–139. https://inlibrary.uz/index.php/science-research/article/view/37031

25. Saini, R., Badole, S.L., Zanwar, A.A. Arginine Derived Nitric Oxide: Key to Healthy Skin. In: Watson, R., Zibadi, S. (eds) Bioactive Dietary Factors and Plant Extracts in Dermatology. 2013 Nutrition and Health. Humana Press, Totowa, NJ. https://doi. org/10.1007/978 1 62703 167 7_8

26. Prokopov A., Drobintseva A., Kvetnoy I. et al. Effect of a hyaluronic acid-based mesotherapeutic injectable on the gene expression of CLOCK and Klotho proteins, and environmentally induced oxidative stress in human skin cells. J Cosmet Dermatol. 2023; 22 (1): 156–172. DOI: 10.1111/jocd.15078

27. Hess J., Angel P., Schorpp-Kistner M. AP 1 subunits: quarrel and harmony among siblings. Journal of cell science. 2004; 117 (Pt 25): 5965–5973. https://doi.org/10.1242/jcs.01589

28. Gazitaeva Z.I., Drobintseva A.O., Polyakova V.O., et al. Novacutan preparations as potential dermatogeroprotectors: molecular-microscopic study. Molecular medicine. 2021; 4: 34–41. https://doi.org/10.29296/24999490 2021 04 06

29. Ivanovskaya Yu., Sidorina A., Gazitaeva Z. The effectiveness of NOVACUTAN SBio exoprotectors in the prevention and treatment of skin photodamage. Aesthetic medicine. 2022; 1 81–85. (In Russ.).

30. Zhaboeva S., Chicherina E., Shabunina E. Combined use of Novacutan products: exoprotectors and fillers in the Healthy Face layered rejuvenation program. Aesthetic medicine. 2021; 1: 62–67. (In Russ.).


Review

For citations:


Gazitaeva Z.I., Zabnenkova O.V. The effectiveness of injectable exoprotectors for recovering facial skin quality. Literature review and clinical observations. Medical alphabet. 2025;(8):100-105. (In Russ.) https://doi.org/10.33667/2078-5631-2025-8-100-105

Views: 44


ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)