

Possibilities of lipofilling in the therapy of vulvar lichen sclerosus
https://doi.org/10.33667/2078-5631-2025-821-25
Abstract
The article presents the application of lipofilling as an innovative method of treating of the vulvar lichen sclerosus (VLS). The main methods of treating VLS are often accompanied by side effects, relapses, or limited effectiveness in the progression of the disease. In this context, lipofilling based on autologous adipose tissue transplantation attracts attention as a promising minimally invasive therapeutic approach. The results of the conducted clinical study confirm the effectiveness of autolipophilling in the treatment of VLS. The obtained research results showed that autolipophilling is a promising method of treating of the vulvar lichen sclerosus, which not only effectively eliminates the symptoms, but also restores the structure of tissues, improving their elasticity and appearance. However, additional research is needed to standardize therapeutic approaches, confirm the effectiveness of the method, and ensure long-term safety.
About the Authors
D. F. PorsokhonovaUzbekistan
Porsokhonova Delya F., DM Sci (habil.), senior researcher, head of the Scientific Laboratory for the Study of STIs and Reproductive
Tashkent
A. I. Yakubovich
Russian Federation
Yakubovich Andrey I., DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology
Irkutsk
R. R. Sadikov
Uzbekistan
Sadykov Rasul R., DM Sci (habil.), senior researcher, assistant professor at Dept of Surgical Diseases
Tashkent
N. N. Ilesova
Uzbekistan
Ilesova Nurjanar N., basic doctoral student
Tashkent
References
1. Babayan A.M., Kalinina N.I. Pathomorphology of lichen sclerosus: modern approaches. Women’s Health Issues. 2019; 11 (2): 22–27. (In Russ.).
2. Gavrilova O.P., Tkachenko P.S. Sclerosus: modern approaches to treatment. Bulletin of Obstetrics and Gynecology. 2019; 4: 29–34. (In Russ.).
3. Grigorieva T. Yu., Orlova N.E. Sclerosus: pathogenesis and clinical manifestations. Bulletin of Gynecology. 2019; 2: 88–92. (In Russ.).
4. Kalinina E. S., Vasilyeva O.A. Modern methods of therapy of lichen sclerosus of the vulva: efficacy and safety. Obstetrics and Women’s Health. 2021; 6: 35–40. (In Russ.).
5. Kuznetsova A.S., Petrova O.G. Clinical and morphological features of lichen sclerosus in women. International Journal of Gynecology. 2020; 8: 36–42. (In Russ.).
6. Almadori G., Bonomi S., Spinelli D. Fat grafting improves fibrosis and scarring in vulvar lichen sclerosus: A prospective cohort study. Journal of Lower Genital Tract Disease. 2020; 24 (2): 175–181.
7. Brown T., Wilson K., Zhang M. Vascular changes in lichen sclerosus: A histological study. International Journal of Gynecology. 2020; 127 (5): 545–550.
8. Casabona G., Papini M., Ferrucci M. Combined autologous fat grafting and platelet-rich plasma in vulvar lichen sclerosus: Quality of life and sexual function outcomes // European Journal of Dermatology. 2023; 33 (4): 412–420.
9. Gutierrez-Ontalvilla P., Ferrer-Santacreu M., Serra-Serra V. Autologous nanofat combined with PRP in the treatment of vulvar lichen sclerosus: A randomized pilot study. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2022; 75 (1): 27–35.
10. Jones R., Davis C., Lee S. Collagen metabolism in vulvar lichen sclerosus // European Journal of Dermatology.– 2019.– Т. 29, № 4.– P. 412–418.
11. Leone R., Masiero E., Busato F. Fat grafting for the treatment of vulvar lichen sclerosus: Clinical and histological evaluation. Gynecologic Oncology Reports. 2016; 19 (4): 123–128.
12. Rigotti G., Marchi A., Galiè M. Autologous fat grafting in dermatological conditions: A systematic review. Plastic and Reconstructive Surgery. 2019; 144 (6): 1219–1231.
13. Smith A., Johnson L., Brown P. Autoimmune mechanisms in lichen sclerosus. Journal of Dermatological Science. 2018; 89 (3): 251–258.
14. Smith A., Taylor D., Brown R. Lipofilling in vulvar lichen sclerosus: A pilot study. Journal of Gynecologic Surgery. 2020; 36 (1): 35–42.
15. Zuk P.A., Zhu M., Ashjian P. Human adipose-derived stem cells: Their role in regenerative medicine. Stem Cells. 2020; 38 (7): 915–923.
Review
For citations:
Porsokhonova D.F., Yakubovich A.I., Sadikov R.R., Ilesova N.N. Possibilities of lipofilling in the therapy of vulvar lichen sclerosus. Medical alphabet. 2025;(8):21-25. (In Russ.) https://doi.org/10.33667/2078-5631-2025-821-25