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Application of oligopeptides in dentistry
Yu. V. Boldyreva,
I. A. Lebedev,
S. N. Lebedev,
O. A. Kuman,
M. V. Korneeva,
O. A. Frolkina,
A. V. Shipitsina,
N. S. Litvinova,
A. Ya. Novoselova,
S. N. Suplotov https://doi.org/10.33667/2078-5631-2025-1-67-70
Abstract
Caries is the most common disease worldwide (95%), despite the promotion and comprehensive prevention of dental diseases, the introduction of fluoride in various forms and a high level of public awareness. A new prospect for stopping the destruction of enamel are products containing oligopeptides (OP). OP are organic molecules consisting of a small number of amino acid residues connected by peptide bonds, which have found wide application in medical practice. One of the representatives is the synthetic, pH-controlled, self-organizing peptide P11-4 (INCI name Oligopeptide 104), used for biomimetic mineralization, including enamel regeneration. Since P11-4 promotes the formation of hydroxyapatite crystals de novo deep within and throughout the entire area of the carious lesion, the use of this agent in dentistry can be considered as a new, effective and non-invasive option for the treatment of enamel caries in the absence of a carious cavity.
About the Authors
Yu. V. Boldyreva
Tyumen State Medical University
Russian Federation
Russian Federation
Boldyreva Yulia V., MD, PhD, Associate Professor, Associate Professor of the Department of Biological Chemistry
Tyumen
I. A. Lebedev
Tyumen State Medical University
Russian Federation
Russian Federation
Lebedev Ilya Arkadyevich, MD, Associate Professor, Professor of the Department of Osteopathy and Traditional Medicine
Tyumen
S. N. Lebedev
Tyumen State Medical University
Russian Federation
Russian Federation
Lebedev Sergey N., MD, PhD, Associate Professor, Associate Professor of the Department of Preventive and Pediatric Dentistry
Tyumen
O. A. Kuman
Tyumen State Medical University
Russian Federation
Russian Federation
Kuman Olga A., MD, PhD, Associate Professor of the Department of Preventive and Pediatric Dentistry
Tyumen
M. V. Korneeva
Tyumen State Medical University
Russian Federation
Russian Federation
Korneeva Maria V., PhD, Associate Professor of the Department of Surgical Dentistry
Tyumen
O. A. Frolkina
Tyumen State Medical University
Russian Federation
Russian Federation
Frolkina Olga Alexandrovna, Assistent at the Departament of Preventive and Pediatric Dentistry
Tyumen
A. V. Shipitsina
Tyumen State Medical University
Russian Federation
Russian Federation
Shipitsina Angelina V., 5th-year student of the Institute of Dentistry
Tyumen
N. S. Litvinova
Tyumen State Medical University
Russian Federation
Russian Federation
Litvinova Natalia S., Senior Lecturer, Department of Biology, Institute of Fundamental Medicine
Tyumen
A. Ya. Novoselova
Tyumen State Medical University
Russian Federation
Russian Federation
Novoselova Anna Y., Assistant, Department of Medical Deontology with UNESCO Bioethics Network Section
Tyumen
S. N. Suplotov
Tyumen State Medical University
Russian Federation
Russian Federation
Suplotov Sergey Nikolaevich, MD, Professor, Head of the Department of Clinical Laboratory Diagnostics
Tyumen
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Review
For citations:
Boldyreva Yu.V., Lebedev I.A., Lebedev S.N., Kuman O.A., Korneeva M.V., Frolkina O.A., Shipitsina A.V., Litvinova N.S., Novoselova A.Ya., Suplotov S.N. Application of oligopeptides in dentistry. Medical alphabet. 2025;(1):67-70. (In Russ.) https://doi.org/10.33667/2078-5631-2025-1-67-70
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