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The role of Acinetobacter baumanii in the etiology of nosocomial infections and possible options for rational antibiotic therapy in adults and children
N. V. Teplova,
S. S. Postnikov,
A. L. Rumyancev,
M. N. Kostyleva,
A. N. Gratsianskaya,
L. B. Belousova,
D. Yu. Dalakyan https://doi.org/10.33667/2078-5631-2024-35-100-107
Abstract
In the mid‑20th century and later, the main bacterial threat in hospitals was gram-positive infections, with staphylococcus aureus (“staphylococcal plague”) playing the leading role. In the last 20 years, there has been an evolution, a change in flora, and now gram-negative infections, especially the triad (A. baumanii, K. pneumoniae, P. aeruginosa) from the ESCAPE group, determine hospital morbidity and mortality due to increasing resistance to carbapenems and cephalosporins and, accordingly, limited choice. In the review concerning the treatment options for A. baumanii in adults and children (especially infants and neonates), antibiotic therapy options are considered.
About the Authors
N. V. Teplova
Dept of Clinical Pharmacology named after Yu. B. Belousov at N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Teplova Natalia V., DM Sci (habil.), professor, head of Dept of Clinical Pharmacology of Faculty of Medicine
Moscow
S. S. Postnikov
Dept of Clinical Pharmacology named after Yu. B. Belousov at N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Postnikov Sergey S., DM Sci (habil.), professor at Dept of Clinical Pharmacology of Faculty of Medicine
Moscow
A. L. Rumyancev
Russian Children's Clinical Hospital – branch of N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Rumyancev Alexander L., PhD Med, head of Hemodialysis Dept
Moscow
M. N. Kostyleva
Dept of Clinical Pharmacology named after Yu. B. Belousov at N. I. Pirogov Russian National Research Medical University;
Russian Children's Clinical Hospital – branch of N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Kostyleva Maria N., PhD Med, associate professor at Dept of Clinical Pharmacology of Faculty of Medicine;
head of Dept of Clinical Pharmacology
Moscow
A. N. Gratsianskaya
Dept of Clinical Pharmacology named after Yu. B. Belousov at N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Gratsianskaya Anna N., PhD Med, associate professor at Dept of Clinical Pharmacology of Faculty of Medicine
Moscow
L. B. Belousova
Dept of Clinical Pharmacology named after Yu. B. Belousov at N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Belousova Lyudmila B., 6th-year student of Pediatric Faculty
Moscow
D. Yu. Dalakyan
Dept of Clinical Pharmacology named after Yu. B. Belousov at N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Dalakyan Daria Yu., 6th year student of Pediatric Faculty
Moscow
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Review
For citations:
Teplova N.V., Postnikov S.S., Rumyancev A.L., Kostyleva M.N., Gratsianskaya A.N., Belousova L.B., Dalakyan D.Yu. The role of Acinetobacter baumanii in the etiology of nosocomial infections and possible options for rational antibiotic therapy in adults and children. Medical alphabet. 2024;(35):100-107. (In Russ.) https://doi.org/10.33667/2078-5631-2024-35-100-107
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