Buy (150 RUB)
|Generate QR code
Open Access
Subscription or Fee Access
Significance of shear wave ultrasound elastography in predicting one-year posthospital outcomes of lower extremity deep vein thrombosis
https://doi.org/10.33667/2078-5631-2024-35-95-99
Abstract
The aim of the study was to analyze the results of shear wave elastography data of iliac and femoral vein thrombi in the acute period of the disease to identify ultrasound parameters that are prognostically significant for posthospital outcomes.
Material and Methods. At the hospitalization stage, 153 patients with iliac and femoral vein thrombosis underwent venous ultrasound with shear wave elastography. Depending on the outcome of the disease 6–12 months after discharge from the hospital, the examined patients were divided into 3 groups: with recanalization, venous retrombosis and death.
Results. In those with the outcome “retrombosis” the thrombus stiffness during inpatient treatment was higher than in the groups with the outcomes “recanalization” and “death”. According to the Accuracy and Gini coefficients for iliac vein thrombosis, the values of maximum and mean Young’s moduli of iliac vein thrombus on the first, third and sixth days of hospitalization, whereas in femoral vein thrombosis – maximum, average and minimum Young’s moduli of femoral vein thrombus on the mentioned days and minimum Young’s modulus of sural vein thrombus on the first day of hospitalization. The variables separating the posthospital outcomes “recanalization” and “death” in iliac vein thrombosis were the maximum Young’s modulus of femoral vein thrombus on the first day of hospitalization and the length of the floating part of the thrombus; in femoral vein thrombosis – the maximum Young’s modulus of the saphenous vein on the first day of hospitalization, the PE mass and the duration of the period from the first symptoms to hospitalization.
Conclusion. The results of shear wave elastography at the hospital stage of management of patients with DVT allow predicting the recurrence of thrombosis in the following year based on the stiffness values of the proximal part of the venous thrombus and lethal outcome based on the stiffness of the thrombus in the inferior vein of the affected limb.
About the Authors
E. G. Akramova
University clinic Kazan (Volga region) Federal University;
Kazan (Volga region) Federal University
Russian Federation
Russian Federation
Akramova Endge G., DM Sci (habil.), associate professor, doctor at Depts of ultrasound and functional diagnostics;
professor at Dept of Preventive Medicine of Institute of Fundamental Medicine and Biology
Kazan
A. A. Saveliev
Kazan (Volga region) Federal University
Russian Federation
Russian Federation
Saveliev Anatoly A., Dr Bio Sci, professor, leading researcher at Educational and Scientific Laboratory "Center for Agro- and Ecobiotechnology" of the Institute of Ecology and Nature Management
Kazan
E. P. Kapustina
Kazan (Volga region) Federal University
Russian Federation
Russian Federation
Kapustina Ekaterina P., doctor at Dept of Ultrasound Diagnostics1, assistant professor at Dept of Preventive Medicine of Institute of Fundamental Medicine and Biology
Kazan
References
1. Kotova EG, Kobyakova OS, Aleksandrova GA, Golubev NA, Oskov YuI, Polikarpov AV, Shelepova EA. General morbidity of the adult population of Russia in 2021: statistical materials. Moscow: Central Research Institute of Oncology and Microbiology of the Ministry of Health of the Russian Federation; 2022. 164p. Russian.
2. Sazhin AV, Lebedev IS, Gavrilov SG, Nechai TV, Shishkina DI, Nechai VS, Efremova OI, Kirienko AI Causes of pulmonary embolism according to autopsies and clinical examination Flebologiya 2019;13(3):202–10. Russian. doi: 10 17116/flebo201913031202.
3. Hasanov VR Clinical and ultrasound characteristcs of treatment of patients with acute thrombosis of deep lower extremity. A new day in medicine. 2020; 2(30):595–8. Russian.
4. Soldatsky EYu, Iumin SM, Khabazova KR, Andriyashkin AV. The late results of the treatment of distal and femoral-popliteal deep venous thrombosis. Journal of Venous Disorders. 2014;8(1):40–9. Russian.
5. Seliverstov EI, Lobastov KV, Ilyukhin EA, Apkhanova TV, Akhmetzyanov RV, Akhtyamov IF, Barinov VE, Bakhmetiev AS, Belov MV, Bobrov SA, Bozhkova SA, Bredikhin RA, Bulatov VL, Vavilova TV, Vardanyan AV, Vorobiev NA, Gavrilov EK, Gavrilov SG, Golovina VI, Gorin AS, Dzhenina OV, Dianov SV, Efremova OI, Zhukovets VV, Zamyatin MN, Ignatiev IA, Kalinin RE, Kamaev AA, Kaplunov OA, Karimova GN, Karpenko AA, Kasimova AR, Katelnitskaya OV, Katelnitsky II, Katorkin SE, Knyazev RI, Konchugova TV, Kopenkin SS, Koshevoy AP, Kravtsov PF, Krylov AYu, Kulchitskaya DB, Laberko LA, Lebedev IS, Malanin DA, Matyushkin AV, Mzhavanadze ND, Moiseev SV, Mushtin NE, Nikolaeva MG, Pelevin AV, Petrikov AS, Piradov MA, Pikhanova ZhM, Poddubnaya IV, Porembskaya OYa, Potapov MP, Pyregov AV, Rachin AP, Rogachevsky OV, Ryabinkina YuV, Sapelkin SV, Sonkin IN, Soroka VV, Sushkov SA, Schastlivtsev IV, Tikhilov RM, Tryakin AA, Fokin AA, Khoronenko VE, Khruslov MV, Tsaturyan AB, Tsed AN, Cherkashin MA, Chechulova AV, Chuiko SG, Shimanko AI, Shmakov RG, Yavelov IS, Yashkin MN, Kirienko AI, Zolotukhin IA, Stoyko YuM, Suchkov IA. Prevention, Diagnostics and Treatment of Deep Vein Thrombosis. Russian Experts Consensus. Flebologiya. 2023;17(3):152–296. Russian. doi: 10.17116/flebo202317031152.
6. Bhatt M, Braun C, Patel P, Patel P, Begum H, Wiercioch W, Varghese J, Wooldridge D, Alturkmani HJ, Thomas M, Baig M, Bahaj W, Khatib R, Kehar R, Ponnapureddy R, Sethi A, Mustafa A, Nieuwlaat R, Lim W, Bates SM, Lang E, Le Gal G, Righini M, Husainat NM, Kalot MA, Al Jabiri YN, Schünemann HJ, Mustafa RA. Diagnosis of deep vein thrombosis of the lower extremity: a systematic review and meta-analysis of test accuracy. Blood Adv. 2020;4(7):1250–64. doi: 10.1182/bloodadvances.2019000960.
7. Akram F, Fan BE, Tan CW, Teoh WC, Prandoni P, Yap ES. The clinical application of venous ultrasound in diagnosis and follow-up of lower extremity deep vein thrombosis (DVT): a case-based discussion. Thromb J. 2023;21(1):110. doi: 10.1186/s12959–023–00550-y.
8. Santini P, Esposto G, Ainora ME, Lupascu A, Gasbarrini A, Zocco MA, Pola R. Ultrasound Elastography to Assess Age of Deep Vein Thrombosis: A Systematic Review. Diagnostics (Basel). 2023;13(12):2075. doi: 10.3390/diagnostics13122075.
9. Akramova EG, Kapustina EP. Shear wave elastography values of thrombus in patients with lower extremity deep vein thrombosis for pulmonary embolism detection: the ROC analysis. Almanac of Clinical Medicine. 2024; 52. Russian. doi: 10.18786/2072–0505–2024–52–002.
10. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.
11. Chernysh IN, Nagaswami C, Kosolapova S, Peshkova AD, Cuker A, Cines DB, Cambor CL, Litvinov RI, Weisel JW. The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli. Sci Rep. 2020; 10(1):5112. doi: 10.1038/s41598–020–59526-x.
12. Rychkova IV, Demidova AK, Kuznetsova AM, Krivosheyeva NV, Zubareva EA, Marushchak EA. Ultrasound elastography in the algorithm of diagnostics of deep venous thrombosis of lower exremities. REJR.2018; 8(2):178–87. Russian. doi: 10.21569/2222–7415–2018–8–2–178–187.
13. Chandrashekar A., Garry J., Gasparis A., Labropoulos N.. Vein wall remodeling in patients with acute deep vein thrombosis and chronic postthrombotic changes. J. Thromb. Haemost. 2017;15(10):1989–93. doi: 10.1111/jth.13793.
14. Zolotukhin IA, Arslanbekov MM, Efremova OI, Lebedev IS, Leontiev SG, Kirienko AI Validity of indications for inferior vena cava filter placement in patients with venous thromboembolism. Flebologiya. 2021;15(2):80–6. Russian. doi: 10.17116/flebo20211502180
Review
For citations:
Akramova E.G., Saveliev A.A., Kapustina E.P. Significance of shear wave ultrasound elastography in predicting one-year posthospital outcomes of lower extremity deep vein thrombosis. Medical alphabet. 2024;(35):95-99. (In Russ.) https://doi.org/10.33667/2078-5631-2024-35-95-99
Views:
112
Email this article 