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Serotonin and intestinal insufficiency in the perioperative period
https://doi.org/10.33667/2078-5631-2024-35-79-88
Abstract
The review is devoted to the problem of postoperative intestinal insufficiency: one of the probable pathophysiological bases of this condition, serotonin deficiency, is considered. The problems of intestinal insufficiency from the point of view of functional and structural disorders of the intestine are considered in detail, the relationship of this condition with the synthesis and metabolism of serotonin is analyzed. Special attention is paid to the accumulated clinical experience in the treatment of intestinal insufficiency through the donation of parenteral serotonin preparations, the advantages and side effects of such therapy, as well as possible complications, are considered in detail. In this regard, emphasis is placed on the most rational and effective approaches to the correction of serotonin deficiency in the treatment of functional intestinal insufficiency of the perioperative period.
About the Authors
D. G. Eremich
North-Western district scientific and clinical center named after L. G. Sokolov Federal Medical and Biological Agency
Russian Federation
Russian Federation
Eremich Darya G., anesthesiologist-resuscitator at Resuscitation and Intensive Care Dept
Saint-Petersburg
I. S. Simutis
North-Western district scientific and clinical center named after L. G. Sokolov Federal Medical and Biological Agency;
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
Simutis Ionas S., DM Sci (habil.), head of Resuscitation and Intensive Care Dept;
associate professor
Saint-Petersburg
M. S. Danilov
North-Western district scientific and clinical center named after L. G. Sokolov Federal Medical and Biological Agency;
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
Danilov Mark S., PhD Me, anesthesiologist-resuscitator at Resuscitation and Intensive Care Dept;
assistant professor
Saint-Petersburg
D. S. Salygina
North-Western district scientific and clinical center named after L. G. Sokolov Federal Medical and Biological Agency
Russian Federation
Russian Federation
Salygina Daria S., anesthesiologist-resuscitator at Resuscitation and Intensive Care Dept
Saint-Petersburg
V. A. Ratnikov
North-Western district scientific and clinical center named after L. G. Sokolov Federal Medical and Biological Agency;
Saint Petersburg State University
Russian Federation
Russian Federation
Ratnikov Vyacheslav A., deputy general director – medical director;
DM Sci (habil.), professor, chief specialist of the Federal Medical and Biological Agency of Russia in Radiation Diagnostics, professor at Scientific and Clinical Educational Center "Radiation Diagnostics and Nuclear Medicine" of Institute of High Medical Technologies of the Faculty of Medicine
Saint-Petersburg
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For citations:
Eremich D.G., Simutis I.S., Danilov M.S., Salygina D.S., Ratnikov V.A. Serotonin and intestinal insufficiency in the perioperative period. Medical alphabet. 2024;(35):79-88. (In Russ.) https://doi.org/10.33667/2078-5631-2024-35-79-88
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