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Pathogenetic and prognostic aspects of copper and zinc deficiency in severely burned patients
https://doi.org/10.33667/2078-5631-2024-35-73-78
Abstract
Objective. To study the copper and zinc content in the severely burned patients’ blood serum and evaluate their capabilities as prognostic criteria for the burn disease outcome.
Materials and methods. 37 patients with a burn area of 50,7±17,2 % of the body surface were examined, 7 of them died. The content of copper, zinc, albumin, globulins and prealbumin in blood serum was assessed within 14 days after receiving thermal injury.
Results. A copper and zinc deficiency was found during the burn shock. In the future, the copper levels normalization and a tendency to the zinc concentration increase with normalization by 14 days after burn injury are noted. The micronutrient deficiency correlation with the albumin, prealbumin and globulins levels was found. The conjugacy between hypocyncemia and hypocupremia with the sepsis presence and the death probability was revealed. A decrease in zinc levels below 4,7 mmol/l leads to a 24-fold increase in the death chances and in copper content below 13 mmol/l – to a 10–fold increase in the chances. The sensitivity and specificity of the zinc concentration threshold value assessment was 71 % and 90 %, respectively, and the copper concentration was 80 % and 75 % respectively.
Conclusion. During the burn shock hypocupremia and hypocyncemia are detected. Further normalization of the copper level and a tendency to zinc concentration normalization were revealed. Zinc and copper concentrations can serve as additional sepsis biomarkers. Threshold values of zinc and copper concentrations in blood serum have been determined which determine the fatal outcome risk of burn disease.
About the Authors
O. V. Kostina
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Kostina Olga V., PhD Bio Sci, senior researcher at Dept of Scientific and Laboratory Research
Nizhny Novgorod
E. A. Galova
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Galova Elena A., PhD Med, deputy director for science
Nizhny Novgorod
M. V. Presnyakova
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Presnyakova Marina V., PhD Bio Sci., biologist of the laboratory of biochemistry and emergency diagnostics
Nizhny Novgorod
A. S. Pushkin
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Pushkin Artem S., anesthesiologist-reanimatologist at Dept of Anesthesiology and Resuscitation of the Burn Center
Nizhny Novgorod
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Review
For citations:
Kostina O.V., Galova E.A., Presnyakova M.V., Pushkin A.S. Pathogenetic and prognostic aspects of copper and zinc deficiency in severely burned patients. Medical alphabet. 2024;(35):73-78. (In Russ.) https://doi.org/10.33667/2078-5631-2024-35-73-78
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