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Gender features of clinical manifestations and quality of life indicators in generalized myasthenia
Kh. F. Yuldashev, 
T. G. Vstavskaya,
E. R. Alibekov,
M. Yu. Afanasyeva,
E. G. Klocheva,
V. V. Goldobin
T. G. Vstavskaya,
E. R. Alibekov,
M. Yu. Afanasyeva,
E. G. Klocheva,
V. V. Goldobin https://doi.org/10.33667/2078-5631-2024-21-26-30
Abstract
Objective. To study the influence of clinical indicators of myasthenia gravis severity to the quality of life of men and women with generalized myasthenia gravis.
Materials and methods. The study included 41 patients aged 60.4±16.4 years with generalized myasthenia gravis: 31 (76 %) women and 10 (24 %) men. Clinical manifestations of myasthenia gravis were assessed with quantitative myasthenia gravis score, myasthenia gravis-specific activities of daily living scale and short form of specialized quality of life questionnaire. Forced vital respiratory capacity was measured in all patients with subsequent additional data calculation.
Results. We revealed significant improvement of examined data during hospitalization in both males and females, but in females, significant improvement was established in all quantitative myasthenia gravis score subscales. In men worse affection of swallowing muscles and severe pain phenomena were revealed. Correlations of physical functioning parameter with total quantitative myasthenia gravis score and with score characterizing the strength of limb muscles were revealed in studying group.
Conclusion. Clinical manifestations and course of myasthenia gravis have the peculiarities n men and women. Quality of life disorder in studying patients correlated with severity of clinical manifestations, mainly with limb weakness.
About the Authors
Kh. F. Yuldashev
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Khosiddin F. Yuldashev - neurologist, postgraduate student at Dept of Neurology named after academician S.N. Davidenkov.
Saint Petersburg
T. G. Vstavskaya
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Tatyana G. Vstavskaya - neurologist, PhD Med, associate professor at Dept of Neurology named after academician S.N. Davidenkov, head of Neurology Dept No. 1 of the Clinic.
Saint Petersburg
E. R. Alibekov
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Ailer R. Alibekov - neurologist, postgraduate student at Dept of Neurology named after academician S.N. Davidenkov.
Saint Petersburg
M. Yu. Afanasyeva
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Marina Yu. Afanasyeva - neurologist, PhD Med, assistant at Dept of Neurology named after academician S.N. Davidenkova, head of Neurology Dept No. 2 of the Clinic.
Saint Petersburg
E. G. Klocheva
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Elena G. Klocheva - neurologist, DM Sci (habil.), professor, professor at Dept of Neurology named after Academician S.N. Davidenkov.
Saint Petersburg
V. V. Goldobin
I.I. Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Vitaliy V. Goldobin - neurologist, DM Sci (habil.), head of Dept of Neurology named after Academician S.N. Davidenkov.
Saint Petersburg
References
1. Khatkhe Yu.A., Zabolotskikh N. V., Ivanisova A. V. et al. Epidemiological features of myasthenia. Kuban Scientific Medical Bulletin. 2018; 25 (1): 195–198.
2. Kryuchkova V. V., Alekseeva T. M., Lobzin S. V. Epidemiological aspects of myasthenia in St. Petersburg. Modern problems of science and education. 2021; (3): 149.
3. Breslav I. S., Nozdrachev A. D. Regulation of breathing: visceral and behavioral components. Advances in physiological sciences. 2007; 38 (2): 26–45.
4. Lapshina O. V., Antipenko E. A., Gustov A. V. Efficiency of complex treatment of various types of myasthenia. Saratov Scientific Medical Journal. 2018; 14 (1): 145–148.
5. Barohn R. J. et al. Reliability testing of the quantitative myasthenia gravis score a. Annals of the New York Academy of Sciences. 1998; 841 (1): 769–772.
6. Wolfe G. I. et al. Myasthenia gravis activities of daily living profile. Neurology. 1999; 52 (7): 1487–1487.
7. Barnett C. et al. The quantitative myasthenia gravis score: comparison with clinical, electrophysiological, and laboratory markers. Journal of clinical neuromuscular disease. 2012; 13 (4): 201–205.
8. Novik A. A., Ionova T. A. Research of the quality of life in medicine: a tutorial / edited by Y. L. Shevchenko. M.: GEOTAR-MED, 2004. 304 p.
9. Ware J. E., Snow K. K., Kosinski M., Gandek B. SF-36 Health Survey: Manual and Interpretation Guide. Lincoln, RI: Quality Metric Inc. 1993; 316.
10. Sakhno Yu.F., Drozdov D. V., Yartsev S. S. Study of the ventilatory function of the lungs: a teaching aid. Moscow: RUDN University Publishing House, 2005. 84 р.
11. Rushkevich Yu.N., Galievskaya O. V., Chechik N. M. et al. The importance of studying the respiratory function in patients with neuromuscular diseases. Medical news. 2020; 2: 22–25.
12. Konkova D. Yu., Karnaukh V. N. Affective disorders in myasthenia. Neurology, neuropsychiatry, psychosomatics. 2016; 8 (4): 21–24.
Review
For citations:
Yuldashev Kh.F., Vstavskaya T.G., Alibekov E.R., Afanasyeva M.Yu., Klocheva E.G., Goldobin V.V. Gender features of clinical manifestations and quality of life indicators in generalized myasthenia. Medical alphabet. 2024;(21):26-30. (In Russ.) https://doi.org/10.33667/2078-5631-2024-21-26-30
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