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Interpretation of reference intervals and clinical decision limits
https://doi.org/10.33667/2078-5631-2024-20-79-82
Abstract
Reference intervals (RI) and clinical decision limits (CDL) are an important part of th e medical information needed to interpret the results of a laboratory tests. The emphasis is on the need to distinguish between the two concepts. RI allows to assess the compliance of the patient’s result with the values detected in a healthy population with a certain probability. CDL is associated with specific diseases and medical risks and may be more significant for clinical decision-making than RI. When interpreting RI and CDL, it is necessary to take into account the possibility of divergence of results on different analytical systems as a potential source of erroneous medical decisions.
About the Authors
V. S. Berestovskaya
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Berestovskaya Victoria S. - PhD Med, associate professor at Dept of Laboratory Medicine with Clinic.
St. Petersburg
A. V. Emanuel
Test-SPb LLC
Russian Federation
Russian Federation
Emanuel Artyom V. - PhD, quality management system lead auditor at Certification Body.
St. Petersburg
I. I. Skibo
TASHIR MEDICA LLC
Russian Federation
Russian Federation
Skibo Irina I. - chief of Laboratory Medicine.
Moscow
V. L. Emanuel
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
Vladimir L. Emanuel - Dr. Sci. (Med.), head of Centre of Molecular Medicine.
St. Petersburg
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Review
For citations:
Berestovskaya V.S., Emanuel A.V., Skibo I.I., Emanuel V.L. Interpretation of reference intervals and clinical decision limits. Medical alphabet. 2024;(20):79-82. (In Russ.) https://doi.org/10.33667/2078-5631-2024-20-79-82
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