Determination of functional relationships between calciuria and plasma calcium metabolism indices

In the presented work, the authors propose to use for the differential diagnosis of factors contributing to calciuria in personal observations the method of visualization of multidimensional relationships using a panel of ratios of laboratory parameters of water-electrolyte metabolism. The calculation of the ratio panel included plasma values: HCT (hematocrit), MSNS (hemoglobin concentration in erythrocyte), Na (sodium), K (potassium), Ca_общ (total calcium), Cl (chlorides), F (phosphates), Kr (creatinine), Ur (urea). Along with these parameters, the following plasma parameters were determined: B-CrossLaps (osteolysis index), TP1NP (osteosynthesis index), VitD, parathyroid hormone, as well as urine pH and calcium. The results obtained, according to the authors, demonstrate the informativeness of the proposed method, which makes it possible to identify the leading complexes of bonds associated with calciuria in individual observations. At the same time, these complexes can differ significantly in their structure in different patients, finding their description in literary sources, thereby demonstrating their differential significance. The authors note that the different “images” of the connections accompanying calciuria established in this study do not exhaust all possible variants of the connections of laboratory parameters associated with the dynamics of calciuria, but as additional laboratory data of patients with various pathologies accumulate, the base of the general array can be significantly expanded. Based on the results obtained and their analysis, the authors conclude that the proposed approach is promising to use in the expert assessment of laboratory parameters as an auxiliary method in analyzing the obtained laboratory data in supporting decision-making and determining the goals of pharmacological correction of calcium metabolism disorders.

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