Features of lipid profile in patients of senile age with coronary artery disease
Abstract
The study aim is to assess the dislipidemia prevalence in patients with coronary artery disease (CAD) older than 75 years as well as to evaluate possible associations between serum lipids and various cardiovascular and other diseases in the very elderly patients. Methods. This project is a cross sectional study enrolled 555 hospitalized patients with CAD older than 75 years. The overwhelming majority of study patients (74.5 %) constituted females. The mean age of patients was 86.8 (±5.0) years varying from 75 to 98 years. Results. Increased total cholesterol level was observed only in 13.3 % of cases; hypertriglyceridemia was revealed in 10.4 % of patients and increase of LDL-C in 26.3 %o, but dislipidemia was mild in the majority of cases. As the age increased, total cholesterol and LDL-C serum levels significantly decreased. Significant negative correlation between TC level and patient s age was revealed (r = -0.13; p = 0.001). Mean TC level in patients aged 75-80 years was 5.43 mmol/L; in patients 80-90 years was 5.0 mmol/L and in subjects 90 years of age and older was 4.7 mmol/L (p = 0.001 for differences between 1-st and 3-d groups). Similar results were registere in respect of LDL-C. Mean LDL-C level in patients younger than 80 years was 3.7 mmol/L; in patients 90 years of age and older was 2.7 mmol/L (p = 0.004). Females had higher concentrations of all lipids than males: mean TC level was 5.1 mmol/l vs 4.5 mmol/l in men (p < 0.0001), LDL-Cwas 3.1 mmol/l vs 2.5 mmol/l (p = 0.0002), HDL-C was 1.26 mmol/l vs 1.17 mmol/l (p = 0.01). Lower lipids concentrations (mainly TC level) were significantly associated with clinically significant heart failure (p < 0.0001) and atrial fibrillation (p < 0.0001). Higher TC and triglycerides levels were correlated with higher blood pressure values (both systolic and diastolic) (p = 0.001). Significant positive correlations between triglycerides and glucose concentration (p < 0.0001) as well as between TG and uric acid level (p = 0.001) were revealed. Higher triglycerides and lower HDL-C levels were registered in patients with higher creatinine level (p = 0.001 and p = 0.0003, respectively). Only 11.4 % of study patients were treated with low doses of statins. Conclusion. The study results demonstrated considerable features of lipid profile in the very elderly patients with CAD. Significant, although ambiguous, associations between dislipidemia and a number of diseases were determined.
About the Authors
S. V. Topolyanskaya
First Moscow State Medical University n.a. I. M. Sechenov
Russian Federation
Russian Federation
N. V. Strizhova
First Moscow State Medical University n.a. I. M. Sechenov
Russian Federation
Russian Federation
O. N. Vakulenko
Hospital for Veterans of Wars No. 3
Russian Federation
Russian Federation
T. A. Eliseeva
Hospital for Veterans of Wars No. 3
Russian Federation
Russian Federation
N. A. Balyasnikova
Hospital for Veterans of Wars No. 3
Russian Federation
Russian Federation
G. A. Kalinin
Hospital for Veterans of Wars No. 3
Russian Federation
Russian Federation
L. M. Kupina
Hospital for Veterans of Wars No. 3
Russian Federation
Russian Federation
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For citations:
Topolyanskaya S.V., Strizhova N.V., Vakulenko O.N., Eliseeva T.A., Balyasnikova N.A., Kalinin G.A., Kupina L.M. Features of lipid profile in patients of senile age with coronary artery disease. Medical alphabet. 2017;1(4):36-42. (In Russ.)
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