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The effect of mebeverine in extended-release capsules on intestinal motor function in patients with functional gastrointestinal pathology
https://doi.org/10.33667/2078-5631-2024-5-7-12
Abstract
Purpose of the study. Evaluation of the clinical effectiveness of combination therapy for FGID with overlap syndrome – gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) using the PPI omeprazole and the myotropic antispasmodic mebeverine hydrochloride in extended-release capsules (Meberin ML, Micro Labs Limited, India) on clinical manifestations and motor-evacuation function of the gastrointestinal tract in patients with FGID with overlap syndrome – GERD, FD with gastric hypersecretion and IBS.
Materials and methods. We examined 27 patients with FGID with overlap syndrome of GERD, FD with gastric hypersecretion of hydrochloric acid and IBS.
Results and conclusion. It has been established that combination therapy with these drugs for two weeks in 97 % of cases eliminates the clinical symptoms of the syndromes, improves the quality of life of patients, normalizes intestinal motility and myoelectric activity of the gastrointestinal tract.
About the Authors
M. A. Butov
Ryazan State Medical University named after Academician I.P. Pavlov
Russian Federation
Russian Federation
Butov Mikhail A. - DM Sci (habil.), professor, head of Dept of Propaedeutics of Internal Diseases.
Ryazan
M. Msakni
Ryazan State Medical University named after Academician I.P. Pavlov
Russian Federation
Russian Federation
Moez Msakni - postgraduate student of Dept of Propaedeutics of Internal Diseases.
Ryazan
V. M. Butova
Ryazan State Medical University named after Academician I.P. Pavlov
Russian Federation
Russian Federation
Butova Valeria M. - PhD Med, associate professor of Dept of Neurology and Neurosurgery.
Ryazan
N. A. Sudakova
City Clinical Hospital No. 4 Ryazan
Russian Federation
Russian Federation
Sudakova Natalia A. - head of the 2nd gastroenterology Dept
Ryazan
I. Yu. Vornacheva
City Clinical Hospital No. 4 Ryazan
Russian Federation
Russian Federation
Vornacheva Irina Y. - head of the 1st Gastroenterology Dept.
Ryazan
L. I. Karpova
City Clinical Hospital No. 4 Ryazan
Russian Federation
Russian Federation
Karpova Lyubov I. - gastroenterologist.
Ryazan
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Review
For citations:
Butov M.A., Msakni M., Butova V.M., Sudakova N.A., Vornacheva I.Yu., Karpova L.I. The effect of mebeverine in extended-release capsules on intestinal motor function in patients with functional gastrointestinal pathology. Medical alphabet. 2024;(5):7-12. (In Russ.) https://doi.org/10.33667/2078-5631-2024-5-7-12
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