Buy (150 RUB)
|Generate QR code
Open Access
Subscription or Fee Access
Dynamics of changes in the microflora of the oral fluid after the removal of lower wisdom teeth against the background of antibiotic therapy and phage therapy
N. A. Oleinik,
E. V. Fomichev,
A. T. Yakovlev,
M. V. Kirpichnikov,
I. V. Khimich,
A. A. Madatkhanova,
A. S. Zlenko,
A. S. Serbin,
K. A. Aleshanov https://doi.org/10.33667/2078-5631-2024-1-16-19
Abstract
The purpose of our study was to study the effectiveness of the drug «Sextafag» as a therapeutic and prophylactic agent after the removal of impacted lower third molars.
Recently, there has been a large number of patients with antibiotic resistance, so it is to find an alternative to traditional antibiotic therapy. This article examines the qualitative and quantitative composition of the oral microbiota after removal of impacted lower wisdom teeth. We studied the dynamics of changes in microflora during antibacterial treatment and phage therapy. The data obtained confirm the clinical and bacteriological effectiveness of oral phage therapy for inflammatory diseases in dental practice and can serve as the basis for the development of a new algorithm for the use of bacteriophages in the treatment of purulent-inflammatory diseases of the oral cavity.
About the Authors
N. A. Oleinik
Volgograd State Medical University
Russian Federation
Russian Federation
Assistant of the Department of Surgical Dentistry and Maxillofacial Surgery.
Volgograd
E. V. Fomichev
Volgograd State Medical University
Russian Federation
Russian Federation
Professor of the Department of Surgical Dentistry and Maxillofacial Surgery.
Volgograd
A. T. Yakovlev
FKUZ Volgograd Research Anti-Plague Institute
Russian Federation
Russian Federation
Professor, Chief Researcher.
Moscow
M. V. Kirpichnikov
Volgograd State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Dentistry and Maxillofacial Surgery.
Volgograd
I. V. Khimich
Volgograd State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Dentistry and Maxillofacial Surgery.
Volgograd
A. A. Madatkhanova
Volgograd State Medical University
Russian Federation
Russian Federation
Assistant of the Department of Surgical Dentistry and Maxillofacial Surgery.
Volgograd
A. S. Zlenko
Volgograd State Medical University
Russian Federation
Russian Federation
Assistant of the Department of Surgical Dentistry and Maxillofacial Surgery.
Volgograd
A. S. Serbin
Volgograd State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of the Department of Surgical Dentistry and Maxillofacial Surgery.
Volgograd
K. A. Aleshanov
Мedical dental center on Zelenogradskaya Co.
Russian Federation
Russian Federation
Candidate of Medical Sciences, Doctor of Surgical Dentistry.
Volgograd
References
1. Sergeev A.N., Morozov A.M., Askerov E.M. Sergeev N.A., Armasov A.R., Isaev Yu.A. Methods of local antimicrobial prevention of infection in the surgical area. Kazan Medical Journal. 2020;101(2):243–248. doi: 10.17816/KMJ2020-243.
2. Antimicrobial resistance (2020). WHO Fact Sheet. Available at: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance. Active 29.03.2022.
3. Álvarez A., Fernández L., Iglesias B., Rodríguez J., Rodríguez A., García, P. Phage Therapy: Unexpected Drawbacks to Reach Hospitals. Future Virol. 2019; 14, 779–782. doi:10.2217/fvl-2019-0154.
4. Aslam S., Lampley E., Wooten D., Karris M., Benson C., Strathdee S., Schooley R. Lessons Learned from the First 10 Consecutive Cases of Intravenous Bacteriophage Therapy to Treat Multidrug-Resistant Bacterial Infections at a Single center in the United States. Open Forum Infect. Dis. 2020; 7(9). doi:10.1093/ofid/ofaa389.
5. Gordillo Altamirano F. L., Barr J. J. Phage therapy in the postantibiotic era. Clin Microbiol Rev. 2019; 32. doi: 10.1128/CMR.00066-18.
6. Beschastnov V.V., Ryabkov M.G., Yudanova T.N., Pavlenko I.V., Leontyev A.E., Tulupov A.A., Kichin V.V. A new possibility of using bacteriophages for the prevention of infections - any complications during free skin grafting (bacteriophages during skin grafting). Bulletin of Siberian Medicine. 2021;20(1):16–22. doi:10.20538/1682-0363-2021-1-16-22.
7. Perepanova T. S., Kazachenko A. V., Khazan P. L., Malova Yu. A. Bacteriophage therapy: back to the future. Clinical microbiology and antimicrobial chemotherapy. 2021; 23(1):55-64. doi:10.36488/smac.2021.1.55-64.
8. Bacteriophages – bacterial viruses: textbook / author – compiler N.V. Ikonnikova, Minsk: Information Computing Center of the Ministry of Finance, 2017. 41s.
9. Nazarov P.A. Alternatives to antibiotics: bacteriophage lytic enzymes and phage therapy. BULLETIN OF THE RUSSIAN STATE MEDICAL UNIVERSITY. 2018; p. 5–15 doi: 10.24075/vrgmu.2018.002
10. Fomichev E.V., Oleinik N.A. The use of Bacteriophages in the complex treatment of purulent-inflammatory diseases of the maxillofacial area. Current problems of experimental and clinical medicine. Volgograd. 2017. 246–247.
11. Fomichev E.V., Poroyckiy S.V., Makedonova Y.A. et. al. The status of local immunityand biocenosis of the oral cavity after the removal of wisdom teeth against the background of phage therapy // Journal of international dental and medical research. 2021. 875–879.
12. Kakasis A, Panitsa G. Bacteriophage therapy as an alternative treatment for human infections. A comprehensive review. Int J Antimicrob Agents. 2019 Jan; 53(1):16–21.
13. Aranaga C, Pantoja LD, Martínez EA, Falco A. Phage Therapy in the Era of Multidrug Resistance in Bacteria: A Systematic Review. Int J Mol Sci. 2022 Apr 21; 23(9): 4577.
Review
For citations:
Oleinik N.A., Fomichev E.V., Yakovlev A.T., Kirpichnikov M.V., Khimich I.V., Madatkhanova A.A., Zlenko A.S., Serbin A.S., Aleshanov K.A. Dynamics of changes in the microflora of the oral fluid after the removal of lower wisdom teeth against the background of antibiotic therapy and phage therapy. Medical alphabet. 2024;(1):16-19. (In Russ.) https://doi.org/10.33667/2078-5631-2024-1-16-19
Views:
290
Email this article 