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Theoretical and practical aspects of acetazolamide use in post-traumatic headache treatment

Abstract

The article deals with the modern understanding of etiopathogenesis of post-traumatic headache. It describes the algorithm of its diagnosis and treatment. It is established that structural, functional and psychopathological changes, which play a different role depending on the severity of the trauma and its stage, are the leading factors in the onset and the development of this cephalalgia. The role of hydrocephalus and sensitization of cerebral neurons in the pathogenesis of post-traumatic headache, including a mild traumatic brain injury, has been clarified. The mechanisms of the action of acetazolamide as a drug inhibiting the production of cerebrospinal fluid and suppressing the activity of brain cells are disclosed. Practical experience and the prospects of using this drug within the framework of pathogenetic therapy and alternative analgesia in post-traumatic headache are discussed.

About the Author

D. A. Iskra
Military Medical Academy n.a. S. M. Kirov
Russian Federation


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Review

For citations:


Iskra D.A. Theoretical and practical aspects of acetazolamide use in post-traumatic headache treatment. Medical alphabet. 2017;3(32):37-40. (In Russ.)

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ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)